Ask about this productRelated genes to: AGXT2L2 antibody
- Gene:
- PHYKPL NIH gene
- Name:
- 5-phosphohydroxy-L-lysine phospho-lyase
- Previous symbol:
- AGXT2L2
- Synonyms:
- MGC15875
- Chromosome:
- 5q35.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-11
- Date modifiied:
- 2014-11-19
Related products to: AGXT2L2 antibody
Related articles to: AGXT2L2 antibody
- Improvement of protein efficiency (PE) is a key factor for a sustainable pig production, as nitrogen excretion contributes substantially to environmental pollution. Protein efficiency has been shown to be heritable and genetically correlated with performance traits such as feed conversion ratio (FCR) and average daily feed intake (ADFI). This study aimed to identify genomic regions associated with these traits through single-variant genome-wide association studies (GWAS) and regional heritability mapping (RHM) using whole-genome sequence variants from low-pass sequencing of more than 1000 Swiss Large White pigs. - Source: PubMed
Publication date: 2025/08/14
Ewaoluwagbemiga Esther OluwadaLloret-Villas AudaldNosková AdélaPausch HubertKasper Claudia - The aim of this study was to screen three major substance metabolism-related genes and establish a prognostic model for osteosarcoma. - Source: PubMed
Publication date: 2025/03/27
Wu TieliWu Xingyi - The aging of the population is a global concern. In the post-coronavirus disease 2019 (COVID-19) pandemic era, there are no effective methods to identify aging acceleration due to infection. In this study, we conducted whole-transcriptome sequencing on peripheral blood samples from 35 healthy individuals (22-88 years old). By analyzing the changes in mRNA, lncRNA, and miRNA expression, we investigated the characteristics of transcriptome alterations during the aging process. ceRNA networks were constructed, and 10 genes (CD248, PHGDH, SFXN2, MXRA8, NOG, TTC24, PHYKPL, CACHD1, BPGM, and TWF1) were identified as potential aging markers and used to construct an aging clock. Moreover, our aging clock categorized individuals into slow-, average-, and quick-aging groups, highlighting a link between accelerated aging and infection-related clinical parameters. Pseudotime analysis further revealed 2 distinct aging trajectories, corroborating the variations in the aging rate identified by the aging clock. Furthermore, we validated the results using the OEP001041 data set (277 healthy individuals aged 17-75), and data sets comprising patients with infectious diseases (n = 1 558). Our study revealed that infection accelerates aging via increased inflammation and oxidative stress in infectious disease patients. Besides, the aging clock exhibited alterations after infection, highlighting its potential for assessing the aging rate after patient recovery. In conclusion, our study introduces a novel aging clock to assess the aging rate in healthy individuals and those with infections, revealing a strong link between accelerated aging and infections through inflammation and oxidative stress. These findings offer valuable insights into aging mechanisms and potential strategies for healthy aging. - Source: PubMed
Gao XinLi Si-JiaCai Jian-Ping - Though interstitial lung disease (ILD) contributes to excess morbidity and mortality in rheumatoid arthritis (RA), RA-ILD pathogenesis remains incompletely defined. As intermediate, non-classical and suppressed CD14+ monocytes are expanded in RA-ILD, this study sought to characterize gene expression profiles of circulating monocytes in RA-ILD. - Source: PubMed
Poole Jill ASchwab AaronThiele Geoffrey MEngland Bryant RNelson Amy JGleason AngelaDuryee Michael JBailey Kristina LRomberger Debra JHershberger DanielVan De Graaff JoelMay Sara MWalenz RhondaKramer BridgetMikuls Ted R - Alternative splicing (AS) and intron retention (IR) implicated in multiple pathophysiological processes, have rarely been reported in systemic sclerosis (SSc). - Source: PubMed
Publication date: 2024/09/12
Xie ShashaBao DingXiao YizhiLi HongdongGuo MuyaoDai BingyingLiu SijiaHuang JingLi MuyuanDing LiqingMeng QimingLv Chun-LiuDistler Jörg H WLuo HuiZhu Honglin