Ask about this productRelated genes to: SCAND3 antibody
- Gene:
- ZBED9 NIH gene
- Name:
- zinc finger BED-type containing 9
- Previous symbol:
- ZNF305P2, ZNF452, SCAND3
- Synonyms:
- ZFP38-L, KIAA1925, FLJ31087, Buster4
- Chromosome:
- 6p22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-20
- Date modifiied:
- 2016-10-05
Related products to: SCAND3 antibody
Related articles to: SCAND3 antibody
- Emanuel syndrome is a rare autosomal disorder characterized by microcephaly, heart defects, cleft palate and developmental delay. However, there is a lack of specific prenatal screening for Emanuel syndrome. To screen for early diagnostic marker genes in fetuses with karyotype+der[22]t(11;22)(q23;q11) of Emanuel syndrome. Transcriptome sequencing and clinical trait data of t(11;22)(q23;q11) translocation samples were screened from the GEO database. The differentially expressed genes (DEGs) were screened by principal component analysis of gene expression by R package, and intersections were taken with balanced and unbalanced DEGs. Then, the correlation with clinical traits was determined by WGCNA analysis, GO and KEGG enrichment analysis, and then univariate Cox analysis and Lasso analysis were performed to obtain the key genes. The core regulatory genes were obtained after protein-protein interaction (PPI) network analysis. A total of 50 DEGs were obtained after differential analysis. WGCNA analysis showed that DEG was associated with the chromosomal imbalance and age module. GO and KEGG enrichment analyses showed candidate genes were associated with exocytic vesicle membrane, synaptic vesicle membranes, glycoprotein complex, dystrophin-associated glycoprotein complex and malaria. COX and Lasso analyses yielded 5 hub genes, including ZBED9, RGS20, SGCB, ETV5, and ZAP70. The results of PPI identified the key regulatory gene associated with chromosomal imbalance as the ZAP70 gene. ZAP70 may be a key gene for early diagnosis of Emanuel syndrome in fetuses with+der[22]t(11;22)(q23;q11) karyotype. - Source: PubMed
Publication date: 2024/04/30
Hu JingWang MengyueXiang Ruiyao - The sex chromosome, especially specific in one sex, generally determines sexual size dimorphism (SSD), a phenomenon with dimorphic sexual difference in the body size. For , a flatfish in China, although the importance of chromosome W and its specific gene in female-biased SSD have been suggested, its family members and regulation information are still unknown. At present, three copies gene were identified on chromosome W, with no gametologs. Phylogenetic analysis for the ZBED family revealed an existence of ZBED9 in the fish. Nine members were uncovered from , clustering into three kinds, ZBED1, ZBED4 and ZBEDX, which is less than the eleven kinds of ZBED members in mammals. The predominant expression of in the female brain and pituitary tissues was further verified by qPCR. Transcription factor could significantly enhance the transcriptional activity of promoter, which is opposite to its effect on the male determinant factor-. When was interfered with, , and were up-regulated, while cell-cycle-related genes, including and were down-regulated. Thus, is involved in cell proliferation by regulating , , cell cycle and the Wnt pathway. Further research on their interactions would be helpful to understand fish SSD. - Source: PubMed
Publication date: 2024/02/23
Sun YuqiLi XihongMai JiaqiXu WentengWang JiachengZhang QiWang Na - Papillary thyroid carcinoma (PTC) is the commonest thyroid cancer. The majority of inherited causes of PTC remain elusive. However, understanding the genetic underpinnings and origins remains a challenging endeavor. An exome-wide association study was performed to identify rare germline variants in coding regions associated with PTC risk in the Middle Eastern population. By analyzing exome-sequencing data from 249 PTC patients (cases) and 1395 individuals without any known cancer (controls), emerged as being strongly associated with rare inactivating variants (RIVs) (4/249 cases vs. 1/1395 controls, OR = 22.75, = 5.09 × 10). Furthermore, three genes, , , and , were enriched for rare damaging variants (RDVs) at the exome-wide threshold ( < 2.5 × 10). An additional seven genes (, , , , , , and were associated with a Middle Eastern PTC risk based on the sequence kernel association test (SKAT). This study underscores the potential of and other implicated genes in PTC predisposition, illuminating the need for large collaborations and innovative approaches to understand the genetic heterogeneity of PTC predisposition. - Source: PubMed
Publication date: 2023/08/24
Bu RongSiraj Abdul KAzam SaudIqbal KaleemQadri ZeeshanAl-Rasheed MahaAl-Sobhi Saif SAl-Dayel FouadAl-Kuraya Khawla S - High blood pressure is widely regarded as the most important risk factor for cardiovascular diseases. Epistasis analysis may provide additional insight into the genetic basis of hypertension. - Source: PubMed
Publication date: 2022/05/13
Akbarzadeh MahdiRiahi ParisaKolifarhood GoodarzLanjanian HosseinAlipour NadiaNajd Hassan Bonab LeilaReza Moghadas MohammadSabour SiamakAzizi FereidounDaneshpour Maryam S - High blood pressure is the heritable risk factor for cardiovascular and kidney diseases. Genome-wide association studies(GWAS) on blood pressure traits increase our understanding of its underlying genetic basis. However, a large proportion of GWAS was conducted in Europeans, and some roadblocks deprive other populations to benefit from their results. Iranians population with a high degree of genomic specificity has not been represented in international databases to date, so to fill the gap, we explored the effects of 652,919 genomic variants on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Hypertension (HTN) in 7694 Iranian adults aged 18 and over from Tehran Cardiometabolic Genetic Study (TCGS). We identified consistent signals on ZBED9 associated with HTN in the genome-wide borderline threshold after adjusting for different sets of environmental predictors. Moreover, strong signals on ABHD17C and suggestive signals on FBN1 were detected for DBP and SBP, respectively, while these signals were not consistent in different GWA analysis. Our finding on ZBED9 was confirmed for all BP traits by linkage analysis in an independent sample. We found significant associations with similar direction of effects and allele frequency of genetic variants on ZBED9 with DBP (genome-wide threshold) and HTN (nominal threshold) in GWAS summary data of UK Biobank. Although there is no strong evidence to support the function of ZBED9 in blood pressure regulation, it provides new insight into the pleiotropic effects of hypertension and other cardiovascular diseases. - Source: PubMed
Publication date: 2021/06/03
Kolifarhood GoodarzSabour SiamakAkbarzadeh MahdiSedaghati-Khayat BaharehGuity KamranRasekhi Dehkordi SaeidAmiri Roudbar MahmoudHadaegh FarzadAzizi FereidounDaneshpour Maryam S