Ask about this productRelated genes to: MPND antibody
- Gene:
- MPND NIH gene
- Name:
- MPN domain containing
- Previous symbol:
- -
- Synonyms:
- FLJ14981
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-02-02
- Date modifiied:
- 2014-11-18
Related products to: MPND antibody
Related articles to: MPND antibody
- Although non-small cell lung cancer (NSCLC) is among the most prevalent malignancies, currently available treatments remain largely ineffective, highlighting the need to elucidate the precise mechanisms of tumorigenesis. The Mpr1/Pad1 N-terminal domain-containing protein (MPND) is a member of the JAMM family of deubiquitinases. In this study, we found that MPND is frequently deleted, and its expression is significantly downregulated in NSCLC tumor tissues. Low MPND levels correlated with poor clinical outcomes, and depletion of MPND enhanced cell migration, invasion, and cancer stem cell-like characteristics in NSCLC cells. Mechanistically, MPND interacted with histones, removing the ubiquitin moiety from monoubiquitinated histone H2A K119 and H2B K120 (H2B K120ub). Loss of MPND elevated the ubiquitination marks, leading to alterations in chromatin architecture. Furthermore, MPND modulated gene transcription, and its depletion activated the transforming growth factor-beta (TGFβ)/SMAD3 signaling pathway. Specifically, the knockout of MPND increased H2B K120ub and chromatin accessibility at the SMAD3 locus, facilitating transcriptional activation. In mouse tumor models and clinical samples from patients with NSCLC, the loss of MPND consistently triggered activation of the TGFβ/SMAD3 axis, thereby promoting tumor growth and metastasis. Together, these data reveal an epigenetic pathway underlying NSCLC progression and suggest that targeting the TGFβ/SMAD3 axis may be particularly effective for the treatment of MPND-deficient NSCLC tumors. - Source: PubMed
Yu JianfengZhang JieruZhang JunBai ZhenqiZhang YunqingLiu Zi'anSu LifanYang YeLian YixinGu WeiZhou JunLi Dawei - The use of traditional mobility datasets, such as travel surveys and census data, has significantly impacted various disciplines, including transportation, urban sensing, criminology, and healthcare. However, because these datasets represent only discrete instances of measurement, they miss continuous temporal shifts in human activities, failing to record the majority of human mobility patterns in real-time. Bolstered by the rapid expansion of telecommunication networks and the ubiquitous use of smartphones, mobile phone network data (MPND) played a pivotal role in fighting and controlling the spread of COVID-19. - Source: PubMed
Publication date: 2025/04/29
Okmi MohammedAng Tan FongMohd Zaki Muhammad FaizKu Chin SoonPhan Koo YuenWahyudi IrfanPor Lip Yee - Butylphthalide has shown significant potential in the treatment of ischemic stroke, but its precise mechanisms of action remain unclear. Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play crucial roles in the pathogenesis of ischemic stroke and may serve as potential therapeutic targets. This study investigated the effects of butylphthalide treatment on the lncRNA-mRNA co-expression network in ischemic stroke patients. - Source: PubMed
Publication date: 2025/04/10
An YangfangHuang LingyunLi JunChen ZhuoCai JizhangWang BiaoZhou Qiong - Depression occurring during the perinatal period (PND) could affect both future mother and father. PND may lead to several adverse physical and mental health outcomes for the whole family. Several psychopathological determinants have been identified, even though few studies investigated the role of paternal mental health in the onset of maternal perinatal depression (MPND). Hence, a retrospective cohort study was carried out in order to investigate the relationship between paternal mental health and the occurrence of antenatal maternal depression as well as identifying potential sociodemographic, clinical and obstetrical predictors in the development of MPND. - Source: PubMed
Publication date: 2025/03/21
Orsolini LauraYılmaz-Karaman Imran GokcenBottaro MatteoBellagamba SilviaFrancesconi GiuliaVolpe Umberto - Immune responses play a key role in the pathogenesis and progression of myeloproliferative neoplasms (MPN) and age-related macular degeneration (AMD). Recent studies suggested using MPNs as a "Human Inflammation Model" of drusen development and previous results showed interleukin-4 (IL-4) dysregulation in MPN and AMD. IL-4, IL-13 and IL-33 are all cytokines involved in the type 2 inflammatory response. This study investigated the cytokine levels of IL-4, IL-13 and IL-33 in serum of MPN and AMD patients. This cross-sectional study included 35 patients with MPN with drusen (MPNd) and 27 with MPN and normal retinas (MPNn), 28 patients with intermediate AMD (iAMD) and 29 with neovascular AMD (nAMD). With immunoassays, we quantified and compared levels of IL-4, IL-13 and IL-33 in serum between the groups. The study was conducted at Zealand University Hospital, Roskilde, Denmark, between July 2018 and November 2020. The serum levels of IL-4 were significantly higher in the MPNd group than in the MPNn group (p = 0.003). In regard to IL-33, the difference between MPNd and MPNn was not significant (p = 0.069), however, when subdivided into subgroups, a significant difference was found between polycythemia vera patients with drusen and those without drusen (p = 0.005). We found no IL-13 difference between the MPNd and MPNn groups. Our data didn't show any significant IL-4 or IL-13 serum level difference between the MPNd and iAMD groups but in regard to IL-33, data recorded a significant serum level difference between the two groups. There was no statistically significant difference between the MPNn, iAMD and nAMD groups in levels of IL-4, IL-13 and IL-33. These findings suggested that the serum levels of IL-4 and IL-33 might play a role in drusen development in MPN patients. The results might represent the type 2 inflammatory arm of the disease. The findings support the association between chronic inflammation and drusen. - Source: PubMed
Publication date: 2023/03/11
Gotfredsen KathrineLiisborg CharlotteSkov VibeKjær LasseHasselbalch Hans CarlSørensen Torben Lykke