Ask about this productRelated genes to: Irx6 antibody
- Gene:
- IRX6 NIH gene
- Name:
- iroquois homeobox 6
- Previous symbol:
- IRX7
- Synonyms:
- IRX-3
- Chromosome:
- 16q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-27
- Date modifiied:
- 2014-11-19
Related products to: Irx6 antibody
Related articles to: Irx6 antibody
- The Iroquois () family of homeobox genes regulates critical developmental processes, and emerging evidence suggests that their dysregulation contributes to cancer progression, particularly in relation to cancer stemness. Although their expression appears to be influenced by hormonal regulation, their potential roles in hormone-sensitive cancers remain incompletely understood. In this study, we performed a comprehensive, exploratory analysis of all six Iroquois genes (-) across prostate, breast, ovarian, and endometrial cancers. Using large-scale publicly available transcriptomic datasets, we systematically examined gene expression patterns and their associations with tumour progression, prognosis, hormone regulation, drug response, and cancer stemness. and were consistently elevated in estrogen-dependent tumours and 2 and 4 were notably upregulated in prostate cancer. Despite evidence of estrogen receptor 1 (ESR1) and androgen receptor (AR) binding near several promoters, estrogen treatment assays showed that ESR1 binding at promoters alone was insufficient to induce transcription. Clinically, 2 expression was associated with favourable outcomes in breast, endometrial, and ovarian cancers and showed correlations with stemness-related signatures in prostate cancer. Similarly, 4 expression was associated with stemness features in prostate and endometrial cancers. In addition, 6 expression showed associations with reduced sensitivity to abiraterone, suggesting a potential link with therapeutic resistance in these tumours. Collectively, these findings highlight the context-dependent expression patterns and clinical associations of genes across hormone-driven cancers. While largely correlative, this study provides a framework for future functional investigations and suggests that selected s may have potential utility as biomarkers for disease stratification and treatment response in hormone-sensitive cancers. - Source: PubMed
Publication date: 2026/02/24
Thennakoon AmaliFernando AchalaBatra Jyotsna - The RAGs, comprising RAG1 and RAG2, catalyze V(D)J recombination by recognizing recombination-signal sequences (RSS). Glioblastoma, the aggressive brain cancer, has many oncogenic chromosomal alterations; however, the mechanism of their generation is largely unknown. Here, we report that RAGs are expressed in human glioblastoma cells at transcript and protein levels. RNA-seq data analysis confirmed the expression of RAGs in the majority of patients with glioma. Analysis of patient breakpoint sequences reveals cryptic RSS in regions undergoing rearrangements. Biochemical studies demonstrate that RAGs can bind and cleave cryptic RSS in fragile regions (AMY1B, CAMK2D, RN7SKP123-MTF2, DIPK1A, IRX5-IRX6), albeit at lower efficiency. Recombination assay using episomes harboring the fragile regions showed aberrant recombination in these regions, and the efficiency was significantly reduced in RAG1 ablated cells. Finally, we recapitulate the glioblastoma associated AMY1B and RN7SKP123-MTF2 chromosomal rearrangement using an extrachromosomal assay. Thus, the present study provides mechanistic insights into the generation of chromosomal aberrations associated with glioblastoma. - Source: PubMed
Publication date: 2025/10/21
Paranjape AmitaKumari SusmitaSahu Lipsa RaniMondal AmritaKunhiraman SwapnaSharma M ArunNilavar Namrata MChoudhary BibhaRaghavan Sathees C - Landau-Kleffner syndrome (LKS), is a rare, poorly-understood epileptic encephalopathy with spike-wave activation in sleep associated with mutations in GRIN2A, encoding the N-Methyl-D-Aspartate receptor (NMDAR) GluN2A subunit. Physicians rely on empirical treatments, with scarce information on treatment efficacy and outcomes. This study aims to improve the understanding and clinical management of LKS. - Source: PubMed
Publication date: 2025/09/13
Ngoh AdelineClark MariaGreenaway RebeccaChen XiuminReid Kimberley MBarwick KatyMeyer EstherMoulding DaleTrump NatalieCross J HelenFraser Sean Dde Hayr LachlanKullmann Dimitri MLynch Joseph WHarvey Robert JKurian Manju A - Hypospadias is one of the most common male congenital external genital malformation anomalies with unclear and multifactorial etiology. Our study aims to investigate whether rs6499755 and rs3816183 polymorphisms are susceptible to hypospadias in Chinese Northern Han. We enrolled 113 patients with hypospadias and 182 healthy controls in the case-control study. Genotyping of single nucleotide polymorphisms (SNPs) was performed using High Resolution Melting (HRM). 113 hypospadias cases were further divided into anterior, middle and posterior subgroups for analysis. In addition, we performed a meta-analysis to evaluate the relationship in multiple populations. The risk allele [C] of rs6499755 was significantly associated with susceptibility to general hypospadias (OR = 1.547, =0.01), anterior hypospadias (OR = 3.579, =0.003) and posterior hypospadias (OR = 1.737, =0.005). Besides, CC genotype carriers showed an increased risk of hypospadias compared with CT + TT carriers (OR = 1.832, =0.026). The risk allele [T] of rs3816183 was associated with susceptibility to anterior/middle hypospadias (OR = 1.775, =0.046). GMDR analysis revealed a significant interaction between rs6499755 and rs3816183 in the risk of hypospadias (cross-validation consistency = 10/10, testing balanced accuracy = 0.6065, =0.0010). The results of meta-analysis (including 3789 cases and 9241 controls) indicated that rs6499755 and rs3816183 were significantly associated with hypospadias (both < 0.00001). rs6499755 and rs3816183 polymorphisms were associated with hypospadias in Chinese Northern Han, and there is a potential interaction between rs6499755 and rs3816183 affecting the risk of hypospadias. The meta-analysis supported the hypothesis that rs6499755 and rs3816183 were the susceptibility loci for hypospadias. Further research is needed to clarify their pathogenic mechanisms. - Source: PubMed
Publication date: 2025/06/13
Liu NanYu YupingChen ZiyingShu JianboChen XiaofangXu GuodongCai Chunquan - The homeobox genes encode transcription factors with fundamental roles in animal development. Despite their link to various congenital conditions in humans, our understanding of gene expression, function, and regulation remains incomplete. Here, we conducted a systematic expression analysis of all six mouse genes in the embryonic spinal cord. We found that , , , , and are expressed in specific groups of motor neurons (MNs). Further, we employed CRISPR-Cas9 gene editing to uncover essential but distinct roles for and in MN development. We also found that HOX proteins, which are conserved regulators of MN development across species, control gene expression both in mouse and MNs. Altogether, our study provides insights into expression and function in the developing spinal cord and uncovers an ancient gene regulatory relationship between HOX and genes. - Source: PubMed
Publication date: 2025/03/12
Catela CatarinaAssimacopoulos StavroulaChen YihanTsioras KonstantinosFeng WeidongKratsios Paschalis