Ask about this productRelated genes to: Irx6 antibody
- Gene:
- IRX6 NIH gene
- Name:
- iroquois homeobox 6
- Previous symbol:
- IRX7
- Synonyms:
- IRX-3
- Chromosome:
- 16q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-27
- Date modifiied:
- 2014-11-19
Related products to: Irx6 antibody
Related articles to: Irx6 antibody
- Soybean first pod insertion height (FPIH) is a key trait established during plant development, but its genetic architecture in Eurasian germplasm remains largely unknown. We performed a GWAS and fine-mapping for FPIH using 180 Eurasian varieties (SoySNP50K array, imputed to ~4M SNPs) phenotyped in four Russian environments (2021-2022), using two models: a residual-based and a covariate-adjusted. SuSiE fine-mapping was applied to refine candidate loci. The covariate-adjusted model demonstrated better control of genomic inflation (λ = 1.08 vs. 1.16) and higher SNP heritability (0.381 vs. 0.014); the lower heritability in the residual-based model was expected, as this model removes environmental main effects and the genetic variance associated with them. Thus, the models are complementary: one captures stable genetic effects, the other highlights environment-dependent signals. SuSiE refined three loci. On chromosome 13, two stable independent signals (Gm13_30553403, Gm13_30909346; PIP ≥ 0.99) were identified near and , consistent across both models. On chromosome 4, the signal shifted to Gm04_36933515 (PIP = 0.9999) near , although model dependency was observed, and this locus is not currently recommended for marker development. On chromosome 5, the original GWAS SNP was not causal; two tightly linked SNPs (Gm05_38427309 and Gm05_38710046, r = 0.714, PIP ≥ 0.99) formed a haplotype block located near and a B-box/CCT domain gene. Crucially, this signal was absent in the residual-based model (max PIP = 0.33), suggesting that the chromosome 5 locus may modulate developmental plasticity rather than exerting a direct main effect on FPIH. However, as we did not perform formal G × E testing, we present this as a hypothesis requiring further validation. The environment-dependent behavior of this locus indicates that it should be used with caution in breeding programs and validated under specific target environments. Chromosome 13 SNPs provide stable genetic associations across environments, whereas the chromosome 5 block requires environment-specific validation. This work provides the first fine-mapped GWAS for FPIH in Russian soybean germplasm and highlights how model choice can uncover or obscure environment-dependent genetic loci affecting plant development. - Source: PubMed
Publication date: 2026/08/24
Zorkoltseva Irina VKirichenko Anatoly VPotapov Dmitriy AKiryukhin Sergey VGurinovich Sergey OPanarina Veronika IPolyudina Revmira ISalina Elena ASvishcheva Gulnara R - The Iroquois () family of homeobox genes regulates critical developmental processes, and emerging evidence suggests that their dysregulation contributes to cancer progression, particularly in relation to cancer stemness. Although their expression appears to be influenced by hormonal regulation, their potential roles in hormone-sensitive cancers remain incompletely understood. In this study, we performed a comprehensive, exploratory analysis of all six Iroquois genes (-) across prostate, breast, ovarian, and endometrial cancers. Using large-scale publicly available transcriptomic datasets, we systematically examined gene expression patterns and their associations with tumour progression, prognosis, hormone regulation, drug response, and cancer stemness. and were consistently elevated in estrogen-dependent tumours and 2 and 4 were notably upregulated in prostate cancer. Despite evidence of estrogen receptor 1 (ESR1) and androgen receptor (AR) binding near several promoters, estrogen treatment assays showed that ESR1 binding at promoters alone was insufficient to induce transcription. Clinically, 2 expression was associated with favourable outcomes in breast, endometrial, and ovarian cancers and showed correlations with stemness-related signatures in prostate cancer. Similarly, 4 expression was associated with stemness features in prostate and endometrial cancers. In addition, 6 expression showed associations with reduced sensitivity to abiraterone, suggesting a potential link with therapeutic resistance in these tumours. Collectively, these findings highlight the context-dependent expression patterns and clinical associations of genes across hormone-driven cancers. While largely correlative, this study provides a framework for future functional investigations and suggests that selected s may have potential utility as biomarkers for disease stratification and treatment response in hormone-sensitive cancers. - Source: PubMed
Publication date: 2026/02/24
Thennakoon AmaliFernando AchalaBatra Jyotsna - The RAGs, comprising RAG1 and RAG2, catalyze V(D)J recombination by recognizing recombination-signal sequences (RSS). Glioblastoma, the aggressive brain cancer, has many oncogenic chromosomal alterations; however, the mechanism of their generation is largely unknown. Here, we report that RAGs are expressed in human glioblastoma cells at transcript and protein levels. RNA-seq data analysis confirmed the expression of RAGs in the majority of patients with glioma. Analysis of patient breakpoint sequences reveals cryptic RSS in regions undergoing rearrangements. Biochemical studies demonstrate that RAGs can bind and cleave cryptic RSS in fragile regions (AMY1B, CAMK2D, RN7SKP123-MTF2, DIPK1A, IRX5-IRX6), albeit at lower efficiency. Recombination assay using episomes harboring the fragile regions showed aberrant recombination in these regions, and the efficiency was significantly reduced in RAG1 ablated cells. Finally, we recapitulate the glioblastoma associated AMY1B and RN7SKP123-MTF2 chromosomal rearrangement using an extrachromosomal assay. Thus, the present study provides mechanistic insights into the generation of chromosomal aberrations associated with glioblastoma. - Source: PubMed
Publication date: 2025/10/21
Paranjape AmitaKumari SusmitaSahu Lipsa RaniMondal AmritaKunhiraman SwapnaSharma M ArunNilavar Namrata MChoudhary BibhaRaghavan Sathees C - Landau-Kleffner syndrome (LKS), is a rare, poorly-understood epileptic encephalopathy with spike-wave activation in sleep associated with mutations in GRIN2A, encoding the N-Methyl-D-Aspartate receptor (NMDAR) GluN2A subunit. Physicians rely on empirical treatments, with scarce information on treatment efficacy and outcomes. This study aims to improve the understanding and clinical management of LKS. - Source: PubMed
Publication date: 2025/09/13
Ngoh AdelineClark MariaGreenaway RebeccaChen XiuminReid Kimberley MBarwick KatyMeyer EstherMoulding DaleTrump NatalieCross J HelenFraser Sean Dde Hayr LachlanKullmann Dimitri MLynch Joseph WHarvey Robert JKurian Manju A - Hypospadias is one of the most common male congenital external genital malformation anomalies with unclear and multifactorial etiology. Our study aims to investigate whether rs6499755 and rs3816183 polymorphisms are susceptible to hypospadias in Chinese Northern Han. We enrolled 113 patients with hypospadias and 182 healthy controls in the case-control study. Genotyping of single nucleotide polymorphisms (SNPs) was performed using High Resolution Melting (HRM). 113 hypospadias cases were further divided into anterior, middle and posterior subgroups for analysis. In addition, we performed a meta-analysis to evaluate the relationship in multiple populations. The risk allele [C] of rs6499755 was significantly associated with susceptibility to general hypospadias (OR = 1.547, =0.01), anterior hypospadias (OR = 3.579, =0.003) and posterior hypospadias (OR = 1.737, =0.005). Besides, CC genotype carriers showed an increased risk of hypospadias compared with CT + TT carriers (OR = 1.832, =0.026). The risk allele [T] of rs3816183 was associated with susceptibility to anterior/middle hypospadias (OR = 1.775, =0.046). GMDR analysis revealed a significant interaction between rs6499755 and rs3816183 in the risk of hypospadias (cross-validation consistency = 10/10, testing balanced accuracy = 0.6065, =0.0010). The results of meta-analysis (including 3789 cases and 9241 controls) indicated that rs6499755 and rs3816183 were significantly associated with hypospadias (both < 0.00001). rs6499755 and rs3816183 polymorphisms were associated with hypospadias in Chinese Northern Han, and there is a potential interaction between rs6499755 and rs3816183 affecting the risk of hypospadias. The meta-analysis supported the hypothesis that rs6499755 and rs3816183 were the susceptibility loci for hypospadias. Further research is needed to clarify their pathogenic mechanisms. - Source: PubMed
Publication date: 2025/06/13
Liu NanYu YupingChen ZiyingShu JianboChen XiaofangXu GuodongCai Chunquan