Ask about this productRelated genes to: ZNF131 antibody
- Gene:
- ZNF131 NIH gene
- Name:
- zinc finger protein 131
- Previous symbol:
- -
- Synonyms:
- ZBTB35, pHZ-10
- Chromosome:
- 5p12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-02-11
- Date modifiied:
- 2014-11-18
Related products to: ZNF131 antibody
Related articles to: ZNF131 antibody
- Sexual dichromatism, characterized by sex-specific differences in coloration, is widespread among birds and often involves carotenoid-based pigmentation. Despite extensive research on the social and ecological environments favoring sexual dichromatism, the molecular mechanisms underlying its development and evolution remain largely unexplored. In this study, we investigated the genetic and molecular processes giving rise to sexual dichromatism in the red ketocarotenoid-based plumage of northern cardinals (Cardinalis cardinalis). We quantified carotenoid concentrations in plasma and feather follicles, confirmed that homologs of CYP2J19, BDH1L, and TTC39B catalyze the production of C-4 ketocarotenoids, and performed gene expression analyses across tissues. Males showed significantly higher plasma and feather ketocarotenoid concentrations, upregulated CYP2J19 and TTC39B expression in liver and feather tissues, and upregulated carotenoid transport gene expression in the gut and feather follicles. Females exhibited a dramatic upregulation of BCO2 in their feather follicles, facilitating carotenoid degradation and attenuating red pigmentation. Additionally, sex-biased expression of hormonal regulators such as HSD17B4 and ZNF131 in the feather follicle suggests hormonal modulation influences dichromatism. These findings indicate that sex-specific regulation of carotenoid processing genes underpins the vivid red coloration in males and the drab phenotype in females, likely maintained by a balance between natural and sexual selection, with mechanisms of sexual antagonism affecting divergent gene expression. This work advances understanding of the molecular basis of avian sexual dimorphism, highlighting key genetic pathways involved in carotenoid-based coloration and providing a foundation for further research into the evolution of sexually dichromatic traits. - Source: PubMed
Publication date: 2026/08/10
Wade Miranda JPatton SaraScheer Elizabeth CKoch Rebecca EZhang YufengToomey Matthew BHill Geoffrey ESin Simon Yung Wa - Exploring targeted therapies for esophageal squamous cell carcinoma (ESCC) remains challenging. Although investigating the roles and therapeutic applications of liquid-liquid phase separation (LLPS) is increasingly of interest, its relationship with ESCC remains unclear. After improving the assay for transposase-accessible chromatin using sequencing (ATAC-seq) protocol for limited-amount clinical samples, we unravel transcription factor AP-2 beta (TFAP2β) as a key downregulated transcription factor (TF) through combined chromatin accessibility and gene expression analyses with cancerous and paracancerous tissues from early-stage ESCC patients. TFAP2β undergoes condensation in the nucleus to bind the zinc finger protein 131 (ZNF131) promoter, thereby inhibiting ZNF131 expression and ESCC progression. The other two crucial downregulated TFs uncovered are incorporated into TFAP2β condensates to bind their corresponding target, suggesting that LLPS may be a hallmark of ESCC transcription. In addition, we obtained compound A6 that mediates intrinsically disordered region conformational changes to enhance TFAP2β condensation and specific ESCC suppression in cells, mice, and patient-derived organoids. Thus, we indicate an LLPS-mediated transcriptional mechanism and a potential therapeutic approach for ESCC. - Source: PubMed
Publication date: 2025/12/16
Deng ZhaominPu LuDeng KaiLiu WenchengZhang JifaZhang LiangMeng QianZhou WanwanJin HaoranXu DongqinQi ShaochongWu ZhihanMa YongxinLiu XingYao XuebiaoKe BowenKerr David JYang LiYang JinlinJiang Hao - PBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated phosphorylation to dissociate from chromosomes in mitosis. Eviction of Ikaros is rapidly reversed by addition of the PBK-inhibitor OTS514, revealing dynamic regulation by kinase and phosphatase activities. To identify more PBK targets, we analysed loss of mitotic phosphorylation events in Pbk preB cells and performed proteomic comparisons on isolated mitotic chromosomes. Among a large pool of C2H2-zinc finger targets, PBK is essential for evicting the CCCTC-binding protein CTCF and zinc finger proteins encoded by Ikzf1, Ikzf3, Znf131 and Zbtb11. PBK-deficient cells were able to divide but showed altered chromatin accessibility and nucleosome positioning consistent with CTCF retention. Our studies reveal that PBK controls the dissociation of selected factors from condensing mitotic chromosomes and contributes to their compaction. - Source: PubMed
Publication date: 2025/09/23
Dimond AndrewGim Do HyeonIng-Simmons ElizabethWhilding ChadKramer Holger BDjeghloul DouniaMontoya AlexPatel BhavikCheriyamkunnel SherryBrown Karen EShliaha Pavel VVaquerizas Juan MMerkenschlager MatthiasFisher Amanda G - Circular RNAs (circRNAs) play critical roles in the occurrence of gastric cancer (GC). However, the roles of proteins encoded by circRNAs in GC remain largely unknown. This study aimed to investigate the role of ZNF131-354aa in GC. circZNF131 overexpression plasmids and short hairpin RNAs were used to overexpress and silence circZNF131 expression levels, respectively. Mass spectrometry, co-immunoprecipitation, and Western blotting were used to identify the circZNF131-encoded protein, named ZNF131-354aa. Chromatin immunoprecipitation assay was used to examine the DNA-binding activity of ZNF131-354aa. A subcutaneous tumor model was established in nude mice to examine the effects of ZNF131-354aa on GC growth. Overexpression of circZNF131 was found to inhibit the proliferation, migration and invasion of GC cells, while knockdown of circZNF131 had the opposite effect. Furthermore, immunoprecipitation and mass spectrometry verified that circZNF131 encoded a 40.5 kDa protein, ZNF131-354aa. ZNF131-354aa was shown to inhibit GC progression. ZNF131-354aa was found to be degraded by tripartite motif-containing 28 (TRIM28)-mediated ubiquitination. Moreover, ZNF131-354aa was found to promote E-cadherin and phosphatase and tensin homolog (PTEN) expression by interacting with the intron of the C-terminal binding protein 2 (CTBP2) gene and repressing its expression. In conclusion, ZNF131-354aa acts as a tumor suppressor in GC by inhibiting CTBP2 transcription. - Source: PubMed
Publication date: 2025/05/15
Wu XinxinLi ZheCao ChunliGe JiaxinShen XiaobanSun WeiliangGuo JunmingGuo Jie - Modern sedentary lifestyles are prevalent among individuals with osteoarthritis. However, direct evidence linking such behaviours as causative factors of osteoarthritis remain limited due to the presence of confounding variables. - Source: PubMed
Ho JustinMak Christopher Chi HangLau Lawrence Chun ManTo KendrickKhan Wasim