Ask about this productRelated genes to: HSF5 antibody
- Gene:
- HSF5 NIH gene
- Name:
- heat shock transcription factor 5
- Previous symbol:
- -
- Synonyms:
- FLJ40311
- Chromosome:
- 17q22
- Locus Type:
- gene with protein product
- Date approved:
- 2006-04-25
- Date modifiied:
- 2018-11-16
Related products to: HSF5 antibody
Related articles to: HSF5 antibody
- The heat shock response is a highly conserved cellular defense mechanism against proteotoxic stress, characterized by the induction of heat shock proteins (HSPs) that function as molecular chaperones to maintain protein homeostasis. Central to this response are the heat shock transcription factors (HSFs), which regulate the expression of HSPs. This Review explores the structural and functional relationships of the mammalian HSF family, including HSF1, HSF2, HSF4 and HSF5. We highlight HSF gene expression and function during organismal development and details of HSFs involvement in neurodegenerative diseases, in which they mitigate/counteract protein aggregation and promote neuronal survival, and in cancer, in which they support tumor growth and metastasis. We also examine the interplay between different HSFs and their context-dependent functions, emphasizing their relevance as potential targets for therapeutic intervention. Understanding the diverse roles of these factors is essential for advancing our knowledge of physiological regulation, and for developing targeted therapies for a broad range of diseases. - Source: PubMed
Publication date: 2026/03/30
Smith Roger SMendillo Marc L - - Source: PubMed
Publication date: 2025/09/23
Luo ChunhaiYu ZiqiLiu DalinXu HaoranZhan JunfengSun Fei - Male blue catfish (Ictalurus furcatus) mature at 4-7 years and cannot be hand-stripped, making sperm collection a lethal procedure. Sperm are also highly variable in quality/quantity. We monitored blue catfish males for 34 months (2.3 to 4.9 years old; y/o) to quantify changes in body morphometrics, plasma androgens, osmolality, ions, testicular development, and gene expression. Body weight and length of fish ranged from 0.6 ± 0.2 to 3.2 ± 0.2 kg and 35.2 ± 2.1 to 58.9 ± 1.9 cm, respectively. Testes weight and gonadosomatic index (GSI) were highly variable within/between sampling points. Maximum testes weight was 6.95 g (4.7 y/o) and GSI was 39.9% (3.7 y/o). Age-associated changes in testicular development were significant, with highest spermatogenic maturity values (0.31-0.73) reported for 3.11 to 4.9 y/o fish and lowest for 2.3 (0.13) and 2.11 (0.12) y/o fish. Spermatozoa were observed in 3.3 and 4.2 to 4.9 y/o fish. The highest ratio of spermatozoa was detected at 4.2 y/o (70%). Androgens spiked at 3.11 y/o, coinciding with reproductive season. An increase in osmolality (mOsm/kg) was observed for 3.11 to 4.5 y/o fish, then decreased. K, Na, and Cl were highest ions throughout development. Transcriptomic analysis revealed 6,317 differentially expressed genes between 2.9, 3.1, 3.9, and 4.2 y/o fish. Most genes were differentially expressed in 3.1 (2,348) and 4.2 (2,689) y/o fish, when compared to 2.9 y/o. Genes related to spermatogenesis and sperm development (cfap61, hsf5, rsph9, dmrt2a, LOC128611646, usp21, gstt1b) were differentially expressed based on age and season. These findings improve our understanding of the reproductive process for an important farm animal. - Source: PubMed
Publication date: 2025/11/20
Martin Kaylan ABosworth Brian GLiyanage Samitha S NWood Kyle RAbernathy Jason WBeck Benjamin HBruce Timothy JRoy Luke ADunham Rex AButts Ian A E - Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I; however, the precise mechanisms regulating these processes remain poorly understood. Our previous work demonstrated that deletion of heat shock factor 5 (HSF5), a member of the heat shock factor family, induces meiotic arrest and male infertility. However, the molecular pathways through which HSF5 governs meiotic progression have not yet been fully elucidated. In this study, a comprehensive multi-omics approach was applied to investigate the role of HSF5 in modulating chromatin dynamics and transcriptional reprogramming during pachynema progression. Analysis of ATAC-seq and single-cell RNA sequencing data revealed significant alterations in chromatin accessibility and disruption of the transcriptional regulatory network (TRN) in spermatocytes. Additionally, HSF5 deficiency resulted in defective XY body formation and altered histone modifications. Notably, spermatocytes also exhibited abnormal spermatoproteasome activity specifically on sex chromosomes, with evidence indicating that HSF5 may form a complex with USP7 to suppress H2AK119ub on meiotic sex chromosomes. These findings provide new insights into the complex, multifunctional role of HSF5 in regulating key meiotic events and advancing our understanding of its function during pachynema progression. - Source: PubMed
Luo Chun-HaiFan Zhi-WeiYu Zi-QiLiu Da-LinXu Hao-RanZhou Shu-MinZhu Xuan-JingLiu Han-ChaoShao Li-FuLi Zhe-AnXie ChongZhan Jun-FengSun Fei - Currently, macaques are used as animal models for human disease in biomedical research. There are two macaques species widely used as animal models, ., cynomolgus macaques and rhesus macaques. These two primates distribute widely, and their natural habitats are different. Cynomolgus macaques distribute in tropical climates, while rhesus macaques mostly distribute in relatively cold environments, and cynomolgus macaques have a common frostbite problem during winter when they are transferred to cold environments. - Source: PubMed
Publication date: 2024/07/10
Wang XuanFeng Ming-HongWang Shao-BoShi Hong