Ask about this productRelated genes to: DUXA antibody
- Gene:
- DUXA NIH gene
- Name:
- double homeobox A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.43
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-08
- Date modifiied:
- 2015-08-27
Related products to: DUXA antibody
Related articles to: DUXA antibody
- To study the maternal contribution to early human embryogenesis by describing the transcriptional dynamics and regulatory roles of maternal effect genes (MEGs) and transcription factors (TFs) throughout the first four cell cycles. This will be achieved using parthenogenotes, such as the human uniparental bioconstruct model. - Source: PubMed
Publication date: 2025/12/08
Vendrell XavierDe Castro PedroEscrich LauraGrau NoeliaGonzález-Martín RobertoQuiñonero AliciaGalán AranchaDomínguez FranciscoEscribà María-José - The maternal-to-zygotic transition (MZT) in embryo development involves the degradation of maternal transcripts and the initiation of zygotic transcription, known as embryonic genome activation (EGA). EGA is marked by the upregulation of several PRDL homeobox family genes in humans. Many orthologues of these genes have recently been identified in bovine based on a comparative analysis with human EGA. Although studies on bovine EGA exist, a comprehensive analysis integrating 5' end mRNA sequencing with PRDL homeobox gene annotations based on cDNA evidence from bovine early embryo development is still lacking. - Source: PubMed
Publication date: 2025/10/14
Yaşar BarışBoskovic NinaOrg TõnisKere JuhaKurg AntsKatayama Shintaro - Abnormal zygotic genome activation (ZGA) during the early development of somatic cell nuclear transfer (SCNT) embryos is one of the main reasons for the low cloning efficiency. The double homeobox (DUX) family, which includes important transcription factors in mammals, has been shown to play an important role in the ZGA process in mice. However, the role of DUXA, a member of the DUX family, in the early development of porcine somatic cloned embryos is unknown. Here, CRISPR/Cas9 gene editing and lentiviral infection technologies were used to construct stable DUXA knockout and overexpression cell lines for the production of SCNT embryos. Compared with that of wild-type (WT) SCNT embryos, the blastocyst rate of DUXA knockout embryos was significantly lower (P < 0.05), whereas the blastocyst rate of DUXA-overexpressing embryos was significantly greater (P < 0.05). Moreover, RT‒qPCR results revealed that DUXA knockout significantly reduced the expression levels of ZGA-related genes (TDG, SNAI1, RSRP1, TFAP2C, ZSCAN4, LEUTX, and KLF17) (P < 0.05). Additionally, in DUXA-overexpressing embryos, the mRNA levels of TDG, SNAI1, RSRP1, and TFAP2C significantly decreased (P < 0.05), whereas the ZSCAN4, LEUTX, and KLF17 mRNA levels increased (P < 0.05). These findings suggest that DUXA regulates the early development of porcine SCNT embryos by modulating the expression of ZGA-related genes. This research provides significant insights into the potential mechanisms of early embryo loss in porcine SCNT. - Source: PubMed
Publication date: 2025/07/05
Shi ZhenhuYan YelianZhu RuiqingZhu XinyueHu KunlongYue YingyingXu WenhuanXuan MengqingGan XinqiYang ZhiyuanZhang YunhaiCao Zubing - Although European genome-wide association studies (GWAS) have aided in defining genetic associations in Dupuytren disease (DD), North American populations have been infrequently analyzed. Additionally, there are a paucity of rare variant analyses (RVA) for DD, which can help define both trait variability and risk for low-frequency variants. Our purpose was to perform a GWAS and RVA for DD using a North American database. - Source: PubMed
Publication date: 2024/11/18
Grandizio Louis CSmelser Diane THaley Jeremy SDelma StephanieKlena Joel CCarey David J - Embryonic genome activation (EGA) is a critical step in early embryonic development, as it marks the transition from relying on maternal factors to the initiation of transcription from embryo's own genome. The factors associated with EGA are not well understood and need further investigation. PRD-like (PRDL) homeodomain transcription factors (TFs) are considered to play crucial roles in this early event during development but these TFs have evolved differently, even within mammalian lineages. Different numbers of PRDL TFs have been predicted in bovine (Bos taurus); however, their divergent evolution requires species-specific confirmation and functional investigations. - Source: PubMed
Publication date: 2024/11/06
Yaşar BarışBoskovic NinaIvask MarilinWeltner JereJouhilahti Eeva-MariVill PiibeSkoog TiinaJaakma ÜlleKere JuhaBürglin Thomas RKatayama ShintaroOrg TõnisKurg Ants