Ask about this productRelated genes to: DBX2 antibody
- Gene:
- DBX2 NIH gene
- Name:
- developing brain homeobox 2
- Previous symbol:
- -
- Synonyms:
- FLJ16139
- Chromosome:
- 12q12
- Locus Type:
- gene with protein product
- Date approved:
- 2007-03-14
- Date modifiied:
- 2014-11-19
Related products to: DBX2 antibody
Related articles to: DBX2 antibody
- Hearing loss (HL) is one of the most common sensorineural disorders, affecting 5% of the world's population. Despite advances in next-generation sequencing (NGS) platforms, the diagnosis of HL remains challenging because of its vast genetic heterogeneity. This study aimed to improve the diagnosis of HL through re-evaluation and new Exome Sequencing (ES) of undiagnosed Iranian HL families. - Source: PubMed
Publication date: 2025/12/18
Rezvandeh Raziye RezvaniKazemi NegarAshrafi Farzane ZareShokouhian EbrahimBolghanabadi ZahraOmrani Mohammad AminEdizadeh MasoudKahrizi KimiaNajmabadi HosseinMohseni Marzieh - Body size and carcass traits are economically significant in livestock, contributing to productivity and meat quality improvement in breeding programs. Understanding the genetic basis of these traits can enhance selection strategies for livestock improvement. This research was carried out to identify genomic regions associated with body size and ultrasound carcass traits using the single-step genome-wide association study (ssGWAS) in Anatolian water buffaloes. Data consisted of wither height (WH), hip height (HH), body length (BL), chest width (CW), hip width (HW), chest circumference (CC), cannon-bone circumference (CBC), Musculus longissimus dorsi depth (MLDD), and subcutaneous fat thickness (SFT) records of 313 yearling buffaloes were used in the association analyses. Genotyping was carried out by using the 90 K Axiom Buffalo Genotyping array. Association analyses using genomic relationship matrix (GRM) were performed by WOMBAT software. - Source: PubMed
Publication date: 2025/11/27
Çinkaya SametTekerli MustafaErdoğan MetinDemirtaş MustafaKoçak SerdarÇelikeloğlu KorayHacan ÖzlemDemirtaş EdaÇinkaya Zeynep NurArzık YunusDemiray AylinSelçuk Senem EsinAkçay AhmetBozkurt ZehraEser OrhanKaplan Yusuf - Predicting the geometry and strength governing small molecule-protein interactions remains a paramount challenge in drug discovery due to their complex and dynamic nature. Several machine learning (ML) methods have been proposed to complement and improve on physics-based tools such as molecular docking, usually by mapping three dimensional features of poses to their closeness to experimental structures and/or to binding affinities. Here, we introduce Dockbox2 (DBX2), a novel approach that encodes ensembles of computational poses within a graph neural network framework energy-based features derived from molecular docking. The model was jointly trained to predict binding pose likelihood as a node-level task and binding affinity as a graph-level task using the PDBbind dataset and demonstrated significant performance in comprehensive, retrospective docking and virtual screening experiments, compared with state-of-the-art physics- and ML-based tools. Our results encourage further exploration of ML models learning from conformational ensembles to accurately model small molecule-protein interactions and thermodynamics. The DBX2 code is available at https://github.com/jp43/DockBox2. - Source: PubMed
Publication date: 2025/09/23
Thaingtamtanha ThanawatPreto JordaneGentile Francesco - In the adult mouse brain, the subventricular zone (SVZ) underlying the lateral ventricles harbours a population of quiescent neural stem cells, which can be activated (aNSCs) to initiate proliferation and generate a neurogenic lineage consisting of transit amplifying progenitors (TAPs), neuroblasts (NBs) and newborn neurons. This process is markedly reduced during aging. Recent studies suggest that the aged SVZ niche decreases the pool of proliferating neural/stem progenitor cells (NSPCs), and hence adult neurogenesis, by causing transcriptomic changes that promote NSC quiescence. The transcription factors that mediate these changes, however, remain unclear. We previously found that the homeobox gene Dbx2 is upregulated in NSPCs of the aged mouse SVZ and can inhibit the growth of NSPC cultures. Here, we further investigate its role as a candidate transcriptional regulator of neurogenic decline. We show that Dbx2 expression is downregulated by Epidermal Growth Factor receptor signaling, which promotes NSPC proliferation and decreases in the aged SVZ. By means of transgenic NSPC lines overexpressing Dbx2, we also show that this gene inhibits NSPC proliferation by hindering the G2/M transition. Furthermore, we exploit RNA sequencing of transgenic NSPCs to elucidate the transcriptomic networks modulated by Dbx2. Among the top hits, we report the downregulation of the molecular pathways implicated in cell cycle progression. Accordingly, we find that Dbx2 function is negatively correlated with the transcriptional signatures of proliferative NSPCs (aNSCs, TAPs and early NBs). These results point to Dbx2 as a transcription factor relaying the anti-neurogenic input of the aged niche to the NSPC transcriptome. - Source: PubMed
Publication date: 2023/08/22
Giuliani AndreaLicursi ValerioNisi Paola SFiore MarioD'Angelo SaraBiagioni StefanoNegri RodolfoRugg-Gunn Peter JCacci EmanueleLupo Giuseppe - Parkinson's disease (PD) is a neurodegenerative disease with an impairment of movement execution that is related to age and genetic and environmental factors. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin widely used to induce PD models, but the effect of MPTP on the cells and genes of PD has not been fully elucidated. By single-nucleus RNA sequencing, we uncovered the PD-specific cells and revealed the changes in their cellular states, including astrocytosis and endothelial cells' absence, as well as a cluster of medium spiny neuron cells unique to PD. Furthermore, trajectory analysis of astrocyte and endothelial cell populations predicted candidate target gene sets that might be associated with PD. Notably, the detailed regulatory roles of astrocyte-specific transcription factors Dbx2 and Sox13 in PD were revealed in our work. Finally, we characterized the cell-cell communications of PD-specific cells and found that the overall communication strength was enhanced in PD compared with a matched control, especially the signaling pathways of NRXN and NEGR. Our work provides an overview of the changes in cellular states of the MPTP-induced mouse brain. - Source: PubMed
Publication date: 2022/09/15
Guo YunxiaMa JunjieHuang HaoXu JitaoJiang ChaoYe KaiqiangChang NingGe QinyuWang GuangzhongZhao Xiangwei