Ask about this productRelated genes to: PODXL2 antibody
- Gene:
- PODXL2 NIH gene
- Name:
- podocalyxin like 2
- Previous symbol:
- -
- Synonyms:
- PODLX2, endoglycan
- Chromosome:
- 3q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-21
- Date modifiied:
- 2016-01-27
Related products to: PODXL2 antibody
Related articles to: PODXL2 antibody
- Aging is the strongest risk factor for Alzheimer's disease (AD), yet the role of age-associated DNA methylation (DNAm) changes in blood and their relevance to AD remains poorly understood. We performed a meta-analysis of blood DNAm samples from 475 dementia-free subjects aged over 65 years across two independent cohorts, the Framingham Heart Study (FHS) at Exam 9 and the Alzheimer's Disease Neuroimaging Initiative (ADNI). We adjusted for sex and immune cell-type proportions and corrected batch effects and genomic inflation. Integrative analyses included pathway enrichment, mQTL analysis, colocalization with Alzheimer's disease and related dementia (ADRD) GWAS summary statistics, brain-blood DNAm correlations, and comparison to independent AD methylation studies. We identified 3758 CpGs and 556 differentially methylated regions (DMRs) consistently associated with chronological age in both cohorts at a 5% false discovery rate. Our pathway enrichment analyses highlighted metabolic regulation and synaptic signaling, processes previously implicated in Alzheimer's disease. Colocalization with ADRD GWAS summary statistics identified 32 genomic regions consistent with shared genetic signals for DNAm and ADRD risk. Roughly one-third of aging-associated CpGs overlapped CpGs associated with AD or AD neuropathology in external studies. Finally, we prioritized nine promoter CpGs (including those located in PDE1B, ELOVL2, and PODXL2) showing strong positive blood-to-brain methylation concordance and external AD associations, nominating them as candidate blood-based biomarkers. Our study demonstrated that late-life aging signatures in blood DNAm converge on processes implicated in AD and intersect with dementia genetics. A small set of CpGs with blood-brain concordance and external AD support offers promising candidate blood-based biomarkers for future validation. - Source: PubMed
Publication date: 2026/04/14
Zhang WeiLukacsovich DavidYoung Juan IGomez LissetteSchmidt Michael AKunkle Brian WChen XiMartin Eden RWang Lily - Cholangiocarcinoma (CCA), an aggressive malignancy of the biliary epithelium, is associated with poorclinical outcomes. The lack of distinct early-stage symptoms often leads to a delayed diagnosis. Therefore, theidentifi cation of reliable biomarkers and therapeutic targets is crucial for improving patient outcomes. Althoughpodocalyxin-like protein 2 (PODXL2) is implicated in other malignancies, its role in CCA remains underexplored. Weaimed to elucidate the functional role of PODXL2 in CCA and determine its prognostic signifi cance in patientoutcomes. - Source: PubMed
Publication date: 2026/03/19
Meng YuZhang YeWei FangZhang RuilinLi ZekangShen YuepingYan HaijiaoWu Jun - Heart failure (HF) represents the end stage of cardiovascular disease and is the leading cause of mortality. The objective of this study was to identify potential biomarkers and elucidate the mechanisms underlying the development of HF across diverse populations and among different genders. - Source: PubMed
Publication date: 2025/10/14
Yu YueXue ChentianJi DongSheng WeiGao XiangWu XizeWu Chengyan - Cell surface proteins are integral to a myriad of biological processes, including cell-cell interactions, signal transduction, and cell adhesion. Notably, these proteins also serve as key receptors for numerous pathogens. However, a comprehensive analysis of the surfaceome remains a significant challenge, primarily due to the high hydrophobicity and low abundance of these proteins. Here, we developed a novel cell surface profiling approach, tyrosinase-mediated cell surface labeling (TYRCSL). Tyrosinase can mildly oxidize a phenol or catechol to the corresponding -quinone, which rapidly reacts with available protein nucleophiles. Leveraging the fast-labeling kinetics (within 1 min) and minimal toxicity of this method, we explored surfaceome dynamics during early stages of influenza A virus (IAV) entry. Our findings reveal that cell surface proteins PODXL2, CNTNAP1, and GPR39 play a crucial role in virus binding and internalization, providing valuable insights into the molecular mechanisms of IAV entry. TYRCSL shows the potential to be applied to the system-wide study of the entry process across a spectrum of pathogens and other instantaneous surfaceome changes under various stimuli. - Source: PubMed
Publication date: 2025/08/22
Liang YuyingChen JianMa ShiyunSong HaoruFeng DaobinYan Guo-QuanZhang YingLu Haojie - Aging is the strongest risk factor for Alzheimer's disease (AD), yet the role of age-associated DNA methylation (DNAm) changes in blood and their relevance to AD remains poorly understood. In this study, we performed a meta-analysis of blood DNAm samples from 475 dementia-free subjects aged over 65 years across two independent cohorts, the Framingham Heart Study (FHS) at Exam 9 and the Alzheimer's Disease Neuroimaging Initiative (ADNI). After adjusting for age, sex, and immune cell type proportions, and correcting for batch effects and genomic inflation, we identified 3758 CpGs and 556 differentially methylated regions (DMRs) consistently associated with aging in both cohorts at a 5% false discovery rate. Our pathway enrichment analyses highlighted immune response, metabolic regulation, and synaptic plasticity, all of which are key biological processes implicated in AD. Moreover, our colocalization analysis revealed 32 genomic regions where shared genetic variants influenced both DNAm and dementia risk. Adjusting for age and other covariate variables, we found roughly one-third of aging-associated CpGs are also associated with AD or AD neuropathology in independent studies external to the ADNI and FHS datasets. Finally, we prioritized 9 aging-associated CpGs, located in promoter regions of , and other genomic regions, that showed strong positive blood-to-brain methylation concordance, as well as association with AD or AD neuropathology in independent studies, after adjusting for age and other covariates. Our findings provided insights into the functional overlap between the aging processes and AD, and nominated promising blood-based biomarkers for future AD research. - Source: PubMed
Publication date: 2025/06/09
Zhang WeiLukacsovich DavidYoung Juan IGomez LissetteSchmidt Michael AKunkle Brian WChen XiMartin Eden RWang Lily