Ask about this productRelated genes to: Dag1 antibody
- Gene:
- DAG1 NIH gene
- Name:
- dystroglycan 1
- Previous symbol:
- -
- Synonyms:
- A3a, 156DAG, AGRNR, DAG
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-22
- Date modifiied:
- 2019-04-23
Related products to: Dag1 antibody
Related articles to: Dag1 antibody
- Environmental pollutant exposure has been associated with chronic kidney disease (CKD), yet specific chemicals related to renal function variation remain incompletely characterized. - Source: PubMed
Publication date: 2026/04/13
Zhou XiaoshanDeng WeitianChu ChengshuangWu QingqingCao YuqingChen WanjiaLiu WangyiYue LingXiao ShifuLi QingrunYin YuanyuanGao XiaojingZeng RongDeng Yueyi - Major depressive disorder (MDD) and inflammatory bowel disease (IBD) exhibit clinical associations, yet the cross-disease genetic links and shared mechanisms between them remain unclear. This study aims to explore the genetic associations between MDD and IBD and identify the shared risk loci, potential key tissues, and related genetic mechanisms. - Source: PubMed
Publication date: 2026/04/07
Ding YifanLuo QinghuaYan XiaojunDeng ChenweiShen PanXu YueqiZhang Leichang - Heat stress can induce skeletal muscle injury. Typical characteristics of heat-exposed muscle tissues include apoptosis, oxidative stress and autophagy. The understanding of molecular mechanisms underlying heat stress-induced muscle injury is limited, especially at the single-cell transcription level. - Source: PubMed
Han ZiyinChen LiLei ZhiyuZhang JiamanChen ZiyuFan XiaolanZeng BoJiang AnanXiang HaiLi HuaLi MingzhouJin Long - Distal cholangiocarcinoma (dCCA) arises from the distal bile duct and is anatomically embedded within the pancreatic head, adjacent to abundant autonomic nerve plexuses. This unique location renders dCCA particularly prone to perineural invasion (PNI), a pathological hallmark that contributes to its dismal prognosis. However, the spatial architecture and molecular drivers that orchestrate PNI remain poorly defined. Here, we applied Xenium subcellular resolution spatial transcriptomics platform to profile resected tumor tissues from dCCA patients stratified by PNI status pathologically. A spatially resolved atlas comprising a total of 20 cell types was generated, uncovering enrichment of Schwann cells, type 2 conventional dendritic cells (cDC2), M2-like macrophages, cancer associated fibroblasts (CAFs) and B/plasma cells in PNI-high tumors, along with depletion of exhausted CD8 T cells. Heterogeneous malignant cells in PNI-high tumors demonstrated activation of extracellular matrix remodeling and axonogenesis pathways, in line with the initial pathological classification. Spatial mapping further revealed distinct PNI-associated niches, notably matrix-producing CAFs (mCAFs)-macrophage clusters exhibiting coordinated enrichment of inflammatory and fibrotic programs. We further identified the LAMB3-DAG1 axis as a potential mediator of dCCA cells-Schwann cell interaction, while the preferential proximity of arteries to Schwann cells suggested additional microenvironmental support for nerve invasion. Collectively, our study provides a comprehensive subcellular atlas of PNI in dCCA, uncovering coordinated epithelial, stromal, and immune remodeling that drives perineural invasion. The identified biomarkers not only hold promise for patient stratification but may also guide intraoperative navigation and surgical margin determination, offering new avenues for precision therapy. - Source: PubMed
Publication date: 2026/01/08
Ji FansenChen HaoLi HuanZhang JiaweiLi SijiaWang PengfeiLiu HaoGe CuiTang BingjunYin HongfangWang XuedongDong Jiahong - The relation between minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) (pFSGS) remains debatable, and the recent discovery of antinephrin and antislit antibodies, supports the hypothesis of a continuum disease. However, the overall expression of podocyte proteins in these disease states is not known. - Source: PubMed
Publication date: 2025/10/11
Fervenza Fernando CVargas-Brochero Maria JDebiec HannaMadden BenjaminAndrade LucianaZand LadanRonco PierreSethi Sanjeev