Ask about this productRelated genes to: Prim1 antibody
- Gene:
- PRIM1 NIH gene
- Name:
- DNA primase subunit 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-26
- Date modifiied:
- 2017-08-08
Related products to: Prim1 antibody
Related articles to: Prim1 antibody
- Urothelial cancer, the most frequently diagnosed cancer of the urinary tract, is the tenth most common cancer globally. DNA primase subunit 1 (PRIM1) is necessary for cancer onset and progression. PRIM1 also serves as a prognostic indicator in invasive breast carcinoma, gastric cell carcinoma, and liver hepatocellular carcinoma. Despite its importance, little is currently known regarding PRIM1's clinical function in urothelial cancer. - Source: PubMed
Publication date: 2026/01/07
Al-Hassany Ban AAl-Sudani Israa M - Salinization of inland waters, driven by climate change and human activities, poses a major threat to aquatic ecosystems. While species can swiftly adapt to environmental stress, the molecular mechanisms underpinning this adaptation remain to be fully elucidated. This study seeks to clarify the complex adaptive strategies employed by the freshwater ciliate in response to chronic salt stress through the methodologies of experimental evolution and multi-omics integration. The findings indicate that three lineages adapted to salt (ST-4, ST-8, and ST-12), which evolved under a regime of increasing NaCl concentration, demonstrated a trade-off between delayed growth and osmotic resilience. Transcriptomic and proteomic analyses revealed key evolutionary priorities, including (i) the co-upregulation of pathways related to DNA replication, glutathione metabolism, and endoplasmic reticulum (ER) protein processing, (ii) the suppression of lipid catabolism alongside the accumulation of lipid droplets mediated by START2, and (iii) mitochondrial remodeling through the expansion of ER contacts to sustain ATP production. Interestingly, the adaptation to salt appears to tolerate genome instability induced by replication stress through the dysregulation of replisome components, specifically the upregulation of Prim1 and downregulation of LIG, while also evading antioxidant defenses via the compartmentalization of oxidative damage. These results contribute to a framework in which protists effectively balance lipid-mediated osmoregulation, controlled mutagenesis, and organelle metabolism to navigate salinity challenges, thereby offering predictive insights into microbial adaptation thresholds within evolving ecosystems.IMPORTANCESalinization of inland waters is a growing concern due to climate change and human activities. Understanding how organisms adapt to saline environments is vital. , a model organism, was studied to explore its adaptation mechanisms. The findings show that through gene regulation, it can acclimate to high salt conditions. The role of mitochondria in metabolic reprogramming during this process is significant. This research contributes to a more profound understanding of how organisms adapt to saline stress and the molecular mechanisms underlying such adaptations, which may aid in predicting and managing the impacts of salinization on aquatic ecosystems. - Source: PubMed
Publication date: 2025/12/23
Yuan FengyuLi WenyuLi AiyunTang TingZhang YumingXie SongLi FengchaoLiu Fengsong - Multiple myeloma (MM) is a challenging hematologic malignancy with increasing incidence. Cuproptosis, a copper-dependent form of cell death associated with mitochondrial metabolism and protein lipoylation, remains unexplored in MM. This study aims to investigate this connection using transcriptome profiling and clinical data from the Gene Expression Omnibus database. Analysis of copper death-related genes (CRGs) revealed significant expression differences in 6 out of 12 CRGs, with GLS, ATP7B, PDHA1, MTF1, CDKN2A and DLAT showing notable correlations with survival of MM patients. Unsupervised clustering identified two cuproptosis molecular subtypes in MM patients, which exhibited significant associations with clinical features, prognosis, and immune cell infiltration. These subtypes identified 186 potential MM target genes, enriched in protein binding and intracellular/extracellular structure regulations. Five key biomarkers (CKS2, HGF, HSP90B1, PRIM1, and VCAM1) effectively stratified patients into high- and low-risk groups, strongly correlated with age, ISS stage, serum LDH content, and survival. Functional enrichment analysis revealed differential genes were involved in regulating cell membrane structure, protein binding, and metabolic pathways. High- and low-risk groups displayed distinct immune cell infiltration patterns and immune checkpoint expressions. In vitro experiments, the combination of elesclomol (a copper ion carrier) and bortezomib (Bortezomib) demonstrated a synergistic anti-myeloma effect through excessive intracellular reactive oxygen species generation. This study provides valuable insights into the role of CRGs in MM, potentially aiding in prognosis prediction and the development of effective, personalized therapeutic strategies. - Source: PubMed
Publication date: 2025/11/15
Xu LiZhang HuiWang KaiGao XuejieBu WenxuanYu DandanHu KeZhang QikaiWang GuanliWu XiaosongJia XinyanPeng YuSong DongliangYi HongfeiCai HaiyanShi JumeiFeng Qilin - Breast cancer is the most common cancer in women worldwide. SETD1A, a histone H3 lysine-4 methyltransferase, is associated with poor prognosis in breast cancer. While both its enzymatic and non-enzymatic functions are implicated in cancer progression, the specific role of SETD1A in breast cancer remains unclear. This study aimed to elucidate the molecular mechanisms underlying SETD1A dependency in breast cancer. - Source: PubMed
Publication date: 2025/08/11
Hayashi KanakoHoshii TakayukiNing MengMatsumoto MakotoIzumi ShintaroFukuyo MasakiRahmutulla BahityarTanabe MasahikoKaneda Atsushi - Sleep apnea (SA) is linked to various diseases. This study examines the causal link between the gut microbiome and SA, exploring potential predictive factors and target proteins using a multi-omics approach with a Phenome-wide association study (PheWAS). - Source: PubMed
Publication date: 2025/06/10
Wei ShuxuShen RonghuaiLu XiaojiaLi XinyiHe LingbinZhang YoutiHuang XianxiShu Zhouwu