Ask about this productRelated genes to: Itga7 antibody
- Gene:
- ITGA7 NIH gene
- Name:
- integrin subunit alpha 7
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-27
- Date modifiied:
- 2019-04-23
Related products to: Itga7 antibody
Related articles to: Itga7 antibody
- The dermal papilla (DP), a specialized fibroblast aggregate in mammalian skin, plays a pivotal role in hair follicle development and regeneration through epithelial‒mesenchymal interactions. While its aggregated configuration is critical for its function, the mechanism promoting and maintaining this organization has remained unclear. Here, we show that human DP cells are embedded in a basement membrane (BM)-like extracellular matrix (ECM) rather than in conventional interstitial fibrillar ECM, such as collagen I. This BM-like ECM occupies the intercellular space as a diffuse, mesh-like structure, with minimal cell‒cell adhesion. DP cells interact with specific laminin isoforms containing α1, α2 or α4 chains via integrin α7β1, resulting in weak adhesiveness. In vitro, a BM extract-based matrix, Matrigel, supports both the formation and maintenance of DP aggregates and is associated with improved DP-marker gene expression, but collagen I gel promotes their dispersion in an α1β1 integrin-dependent manner. These findings highlight a BM-like ECM niche as a key determinant of DP cohesion. - Source: PubMed
Publication date: 2026/04/17
Machida HirokiYokota JunFujiwara Hironobu - Cancer cachexia leads to decreases in body mass, lean mass and fat mass, decreased therapeutic potential and ~20% of cancer-related deaths. While several studies have demonstrated changes to components of the muscle microenvironment with cancer cachexia, none have comprehensively assessed changes to cellular dynamics across the duration of cachexia development. - Source: PubMed
Brown AlexCollao NicolásSaleh AishaStrong NatashaDe Lisio MichaelWiper-Bergeron Nadine - Type 2 diabetes mellitus (T2DM) is frequently accompanied by progressive skeletal muscle loss and dysfunction, commonly referred to as diabetic sarcopenia. Exercise is an established non-pharmacological therapy for T2DM; however, how different exercise modalities differentially influence skeletal muscle protein regulation and anabolic signaling remains unclear. This study compared the effects of aerobic exercise, resistance exercise, and their combination on skeletal muscle protein content and irisin-associated anabolic signaling in a rat model of T2DM. - Source: PubMed
Publication date: 2026/03/03
Zhang Yi-DanZhao Xiang-XingLiu Xia - Breast carcinoma represents the most prevalent form of invasive neoplasia among the female population globally, and is distinguished by its molecular heterogeneity by significant genomic instability. The discipline of bioinformatics provides essential tools for the identification of novel biomarkers and enhances the prospects for subsequent experimental investigations. Differentially expressed messenger RNAs were assembled by employing datasets sourced from the Gene Expression Omnibus repository. Intersection of DEGs and proteins involving in the integrin cell surface interactions were done. Ce-RNA network were constructed and Functional analysis were done. Protein expression analysis, methylation and, Correlation analysis as well as drug sensitivity analysis for the hub genes were performed. The expression of FN1 were evaluated using Real-Time PCR for 45 invasive ductal carcinoma breast tissues and adjacent normal samples. We found FN1, CDH1, COMP, SPP1 and ITGA7 to act in integrin cell surface interactions. The Ce-RNA network consisted of 126 nodes and 192 edges which the network nodes were significantly enriched in known cancer pathways. Protein expressions of FN1, CDH1, COMP was upregulated while ITGA7 were downregulated. The methylation levels in ITGA7 and SPP1 promoter regions were significantly altered across all stages compared to normal. In contrast, FN1 and CDH1 promoter regions exhibited dysregulation only in stage 3 relative to normal. A correlation study identified five positive and three negative gene correlations. Altered expression of FN1, SPP1, CDH1, and ITGA7 in breast cancer enhanced cancer cell susceptibility to specific pharmacological molecules. FN1 expression was markedly higher in breast cancer tissues compared to non-cancerous tissues, showing a threefold increase (p < 0.0001). Both early-stage and advanced-stage cancers showed higher FN1 levels (p = 0.002, p = 0.01). Additionally, FN1 was higher in lower histological grade tissues (p = 0.0002). In ROC curve analysis with limited stage III samples, FN1 showed potential for diagnosing IDC, achieving an AUC of 0.82. We identified FN1 as a highly connected component of integrin cell-surface interactions in breast cancer and provide hypothesis-generating associations with drug sensitivity; these findings require further protein-level validation and functional testing before translational application. - Source: PubMed
Publication date: 2026/02/25
Sadeghi MahboubehGhaderi AbbasMousavi PegahSabetian SoudabehRamezani AminHaghshenas Mohammad Reza - Cardiac hypertrophy is a pathological response to increased myocardial stress and a key contributor to heart failure. The Hypertrophic Heart Rat (HHR) is a well-established model for investigating primary cardiac hypertrophy in the absence of hypertension. This study aimed to characterise the role of microRNAs and their downstream regulatory pathways in neonatal HHRs to identify mechanisms contributing to early-onset hypertrophy. Heart tissue from 2-day-old HHRs and Normal Heart Rats (NHRs) was analysed using microarray profiling to identify differentially expressed miRNAs and mRNAs. Gene Set Enrichment Analysis (GSEA) was performed to identify biological pathways associated with miRNA target genes followed by selected miRNA and genes validated by quantitative reverse transcription PCR (RT-qPCR). Neonatal HHRs demonstrated a significantly elevated cardiac weight index compared to NHRs, with upregulation of hypertrophic markers including NPPA, NPPB, and MAPK1. Microarray analysis revealed 107 differentially expressed miRNAs, among which miR-34a, miR-351, and miR-490* were validated and further analysed. These miRNAs were linked to key hypertrophic pathways including RAS-MAPK and PI3K-AKT along with calcium signalling. miR-34a was experimentally validated to target HTR2A, implicating serotonin signalling in neonatal cardiac remodelling. Additionally, elevated SGPP1 expression suggests increased sphingolipid metabolism, while ITGA7 was reduced and GANC showed a modest decrease, indicating dysregulation in mechano-signal transduction and glycogen metabolism. These findings provide insight into the early molecular drivers of cardiac hypertrophy in neonatal HHR and delineate miRNA-mRNA relationships involved in remodelling. This study lays the groundwork for future investigations into the therapeutic potential of targeting miRNA pathways in the prevention and management of pathological cardiac remodelling. - Source: PubMed
Publication date: 2025/12/30
Sadiq ShahzadCharchar Fadi JSanigorski AndrewCrowley TamsynBookun Hansraj RMcClure David N