Ask about this productRelated genes to: CDS1 antibody
- Gene:
- CDS1 NIH gene
- Name:
- CDP-diacylglycerol synthase 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4q21.23
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-03
- Date modifiied:
- 2016-10-05
- Gene:
- CHEK2 NIH gene
- Name:
- checkpoint kinase 2
- Previous symbol:
- RAD53
- Synonyms:
- CDS1, CHK2, HuCds1, PP1425, bA444G7
- Chromosome:
- 22q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-19
- Date modifiied:
- 2019-04-23
Related products to: CDS1 antibody
Related articles to: CDS1 antibody
- Cold atmospheric helium plasma (CAP) is a promising tool for cancer therapy. However, the mechanisms underlying CAP-induced DNA damage responses and cell death remains incompletely understood. Here, we investigated the role of the ATM-Chk2 pathway in CAP-induced cellular responses using a matched pair of p53-proficient (Molt-4/V) and p53-knockdown (Molt-4/shp53) cells. CAP exposure induced γH2AX/53BP1foci formation and activated ATM and Chk2 in both cell lines. CAP-induced cell death was more prominent in Molt-4/V cells, supporting a proapoptotic role of p53. In Molt-4/V cells, inhibition of ATM or Chk2 suppressed p53 accumulation and reduced CAP-induced cell death. In contrast, Chk2 inhibition modestly enhanced CAP-induced in Molt-4/shp53 cells cell death, suggesting a cytoprotective role for Chk2 in cells with reduced p53 expression. Hydrogen peroxide partially reproduced CAP-induced DNA damage response but with weaker effects, whereas nitrite had minimal impact under the condition tested. Collectively, these findings indicate that the ATM-Chk2 pathway contribute to CAP-induced cell death in a p53 dependent manner and suggest that its functional role differs according to p53 status, providing insight into how CAP-induced DNA damage response are modulated by p53 status. - Source: PubMed
Publication date: 2026/05/05
Muratani TamakiIwashima KanaSakamoto FuunaIshibashi RikoTabuchi YoshiakiMorita AkinoriEnomoto AtsushiNagai YoshinoriKondo TakashiTanaka HiromasaFurusawa Yukihiro - Cellular senescence, a state of permanent cell cycle arrest, contributes to tissue dysfunction and aging through the accumulation of apoptosis-resistant senescent cells. Although the transcription factor FOXO4 is known to enhance senescent cell survival, the mechanisms regulating its stability have remained unclear. Here, we identify a DNA damage response (DDR)-driven CHK2-USP37-FOXO4 axis essential for maintaining the apoptotic resistance of senescent cells. We demonstrate that FOXO4 protein stability is elevated in stress-induced senescent cells, resulting from reduced ubiquitin-proteasomal degradation. A deubiquitinase screen identified USP37 as the key enzyme stabilizing FOXO4 through direct interaction and removal of K48-linked polyubiquitin chains. Depletion of USP37 destabilizes FOXO4 and sensitizes senescent cells to apoptosis. Mechanistically, persistent DDR signaling during senescence activates CHK2, which phosphorylates USP37 at Thr589, thereby enhancing its binding to FOXO4. Importantly, ablation of USP37 in senescent cells increases the rate of apoptosis, a phenotype that is rescued by FOXO4 reexpression. Together, our work unveils USP37 as a CHK2-regulated stabilizer of FOXO4 that maintains the apoptotic resistance of senescent cells, suggesting the CHK2-USP37-FOXO4 axis as a therapeutic target for age-related pathologies. - Source: PubMed
Publication date: 2026/04/14
Sun JiahuiGeng AnkeSong ZhiweiChen LingjiangZhang Zhen-NingJiang YingMao Zhiyong - Cyclotides are plant-derived cyclic peptides with remarkable structural stability and broad-spectrum bioactivities, including anticancer potential. However, the mechanisms of action of these agents against tumors remain largely unclear. Viola diffusa, a traditional medicinal plant native to southern China, contains abundant cyclotides, whose therapeutic potential against non-small cell lung cancer (NSCLC) remains to be thoroughly investigated. - Source: PubMed
Publication date: 2026/04/01
He FaweiHe QuankuoLi YanpingRen JieTang XueMao KailinZhangsun DongtingGao BingmiaoLuo SulanWu Yong - The average age of natural menopause (ANM) for European women is 50-52 years. Reproductive risk and lifestyle factors have been found to be associated with ANM. Furthermore, a genome-wide association study found that women with a variant reach ANM 3.49 years later than women without a variant ('non-carriers'). With this study, we aim to validate this association within c.1100delC families. - Source: PubMed
Publication date: 2026/04/20
Schreurs Maartje A CHollestelle AntoinetteAdank Muriel ALouwers Yvonnevan Asperen Christi JAusems Margreet G E Mvan de Beek IrmaCollee Margriet JDommering Charlotte JGómez García Encarna BWevers Marijke RVieveen Emma MYigit RefikaSchmidt Marjanka KVisser Jenny AHooning Maartje J - PARP inhibition has demonstrated efficacy in patients with platinum-sensitive pancreatic cancer with germline BRCA1/2 pathogenic variants (PV). Whether PARP inhibitors might be effective in a broader population of patients with pancreatic cancer remains under investigation. - Source: PubMed
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