Ask about this productRelated genes to: Decr2 antibody
- Gene:
- DECR2 NIH gene
- Name:
- 2,4-dienoyl-CoA reductase 2
- Previous symbol:
- -
- Synonyms:
- PDCR, SDR17C1
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-15
- Date modifiied:
- 2016-12-02
Related products to: Decr2 antibody
Related articles to: Decr2 antibody
- To investigate the association between serum folate and Primary biliary cholangitis (PBC) progression through clinical, transcriptomic, and protein-level analyses. - Source: PubMed
Publication date: 2026/06/03
Yan YujieMu QieLi BonanSun YuqingYang HongHuang ZhiqinYu BaofengZhang LiHuang Huifang - Tibetan chickens have evolved a unique energy metabolism that enables them to survive in high-altitude environments characterized by hypoxia. However, the genetic basis of this trait remains unclear. In this study, eggs from Tibetan and Leghorn chickens were incubated in hypoxic conditions (13 % O). After 16 days, RNA-seq was performed on 23 liver tissues from 13 Tibetan and 10 Leghorn chicken embryos. Six ATAC-seq datasets were also generated from three Tibetan and three Leghorn chickens, respectively. Differential expression analysis revealed that 2,421 genes were down-regulated and 1,785 genes were up-regulated in the livers of Tibetan chicken embryos. A total of 414 significant differentially accessible regions (DARs) were identified between the two breeds. Of these, 400 were upregulated and 14 were downregulated in Tibetan chickens. Combined analysis of ATAC-seq and RNA-seq data revealed that 102 of the upregulated genes were associated with the gain of DARs in Tibetan chickens. However, no down-regulated genes were found to overlap with the loss of DARs in Tibetan chickens. Several genes, including ACLY, OGDH, PDHB, ECI1, ACAT2, HMGCL, DECR2, and EPHX2, were identified as potentially contributing to hypoxic adaptation in Tibetan chickens during the embryonic stage. These genes carry upregulated peaks and are involved in the TCA cycle and fatty acid degradation. In particular, several transcription factors (TFs), belonging to the kruppel-like factor (KLF), peroxisome proliferator-activated receptors (PPAR) and hepatocyte nuclear factor (HNF) families, which are involved in lipid metabolism and energy homeostasis, were identified in the gain peaks of Tibetan chickens. These results highlight the vital role of enhancing the liver's capacity to supply energy in the hypoxic adaptation of Tibetan chickens. Overall, our results provide new insights into the epigenetic modifications and transcriptional regulation of this adaptation, suggesting avenues for future research into the hypoxic adaptation of highland animals. - Source: PubMed
Publication date: 2025/12/13
Guo XingZhang BoChen ZihanChen XuejiaoZhang ChuchuWei WeiMa WendiJiao JingranZhang HaoWang MingshanJiang Runshen - Alzheimer's disease (AD) and schizophrenia (SZ) are two complex neuropsychiatric disorders characterized by significant cognitive impairment. The relationship between them is complex and multifaceted. Understanding these similarities and differences is crucial for identifying common therapeutic targets. Genetic data on plasma proteome were obtained from Icelandic datasets. Genetic variants associated with circulating inflammatory proteins, rheumatoid arthritis (RA) and AD and SZ, were sourced from large GWAS datasets. Mendelian randomization analyses were performed, and transcriptome analysis were applied to confirm the finding. We observed an association between the genetic loci of the AD and SZ traits (p < 0.05) by Linkage Disequilibrium Score Regression. Furthermore, our analysis indicates that RA has a protective effect against AD (OR: 0.36, p = 0.005) while potentially increasing the risk for SZ (OR: 2.49, p = 2.06 × 10⁻⁷). Among the 1,729 proteins analyzed, 16 proteins exhibited significant inverse causal relationships with AD and positive causal relationships with SZ. Notably, DECR2 emerged as a potential therapeutic target, showing opposing effects in AD and SZ as revealed by SMR analysis and colocalization. This study identifies causal proteins linked to AD and SZ, enhancing the understanding of their molecular etiology and supporting targeted therapeutics development. - Source: PubMed
Publication date: 2026/01/01
Zhang YupingShao JuLiang BiboHe YihongWen ZhixinCai BoJie Ligang - Immune checkpoint blockade therapies have transformed the landscape of cancer care, but durable clinical responses are achieved in only a subset of patients. To identify genes that can contribute to immunotherapy resistance, a genome-wide CRISPR screen was performed. Selection for mutants that are resistant to T cell-mediated killing identified the gene encoding Decr2, a peroxisomal 2,4-dienoyl-CoA reductase. We show that Decr2 in tumor cells participates in CD8+ T cell-mediated tumor cell killing and that Decr2 knockdown reduces the efficacy of anti-PD-L1 therapy in vivo. Knocking down Decr2 expression resulted in diminished ferroptosis that was associated with reduced induction of polyunsaturated ether phospholipids. Analysis of tumor RNA sequencing data from patients with melanoma revealed that upregulation of Decr2 was associated with anti-PD-1 efficacy, and patients with Decr2 gene deletions showed worse clinical outcomes. Our results identify Decr2 as a regulator of immunomediated tumor cell killing, with implications for improving immunotherapy efficacy. - Source: PubMed
Li ShuyinShapiro Jason WShah HardikHiggs Emily FXie LishiLi YaopengZha YuanyuanTrujillo JonathanCabanov AlexandraJones Tyler AFlood BlakeHatogai KenTonea RuxandraKline JustinGajewski Thomas F - In B-cell precursor acute lymphoblastic leukemia (BCP-ALL), chromosomal translocations are strongly associated with prognoses. RNA sequencing (RNA-seq) is a powerful technology that reveals a close correlation between types of translocation and patterns of gene expression in clinical samples of BCP-ALL. Cancer cell lines are powerful research tools, and thus, we built a larger series of BCP-ALL cell lines and performed RNA-seq analysis to confirm their utility as a model system. - Source: PubMed
Tamai MinoriKomatsu ChiakiKagami KeikoKasai ShinAkahane KoshiGoi KumikoSugita KanjiTomoyasu ChihiroImamura ToshihikoGoto HiroakiInukai Takeshi