Ask about this productRelated genes to: PPAP2A antibody
- Gene:
- PLPP1 NIH gene
- Name:
- phospholipid phosphatase 1
- Previous symbol:
- PPAP2A
- Synonyms:
- PAP-2a, LPP1
- Chromosome:
- 5q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-02
- Date modifiied:
- 2016-10-05
Related products to: PPAP2A antibody
Related articles to: PPAP2A antibody
- Rat adipose tissues were shown to exhibit a high level of autotaxin having lysophospholipase D activity. Previously, we reported that an elevated level of lysophosphatidic acid (LPA) in rat plasma was due to a decreased lysophosphatidylcholine concentration, increased plasma lysophospholipase D activity, and decreased lipid phosphate phosphatase activity toward LPA in adrenalectomized (ADL) rats. We hypothesized that the profiles of LPA, its precursor lysophospholipids (LPLs), and parent phospholipids (PLs) also may be altered in adipose tissues of ADL rats. To examine this possibility, we determined the tissue levels of molecular species of PLs and LPLs, including LPA, by LC-tandem MS. The levels of six LPLs in rat brown adipose tissue (BAT) were increased in ADL rats. In rat epididymal white adipose tissue (EpiWAT), the levels of LPLs except for LPA were increased. In rat inguinal WAT, the level of phosphatidylglycerol was increased. These results suggest that tissue levels of LPLs were upregulated by adrenal hormones in BAT and EpiWAT by different mechanisms. - Source: PubMed
Tsutsumi ToshihikoKawabata KoheiNishi HiroyukiTokumura Akira - - Source: PubMed
Publication date: 2026/07/29
- Repeated psychological stress is a major risk factor for psychiatric disorders. Sphingosine 1-phosphate (S1P), a bioactive sphingolipid, is known to contribute to regulating central nervous system functions. However, the relationship between the onset of psychological stress-induced behavioral disorders and S1P metabolism in the brain remains poorly understood. Because prefrontal cortex (PFC) and hippocampus are key brain regions involved in psychological stress responses, we investigated whether repeated social defeat stress (SDS) alters S1P metabolism in these regions. The S1P levels in the PFC, but not in the hippocampus, of mice susceptible to 4-day SDS were markedly lower than those in the control mice and were positively correlated with sociability. Additionally, mRNA expressions of an S1P-degrading enzyme Plpp3 and an inflammatory mediator Hmgb1 were increased in the PFC of 4-day SDS-susceptible mice. These results suggest that impaired S1P signaling in the PFC is associated with the onset of psychosocial stress-induced social avoidance. - Source: PubMed
Morito KatsuyaKimura SuzumiFujisawa SakiNishimura YukiTakayama Kentaro - Myopia is one of the most common eye diseases affecting children and adolescents, with its etiology often attributed to a combination of genetic and environmental factors. This study utilized single-cell RNA sequencing (scRNA-seq) technology to investigate gene expression differences between guinea pigs with spontaneous high myopia (SHM) and those with normal vision. - Source: PubMed
Publication date: 2026/07/02
Bao BoLiu JinpengXie YunxiaoXi RuofanSun YuecongYan JingzheXin JizhaoYang ZhaohuiYin XueweiGuo DadongBi Hongsheng - Lipid phosphate phosphatases (LPPs) dephosphorylate lipid phosphates to regulate signaling and metabolism. Among the three mammalian isoforms, LPP1, LPP2, and LPP3, LPP2 has been strongly associated with cancer, making it a potential therapeutic target. However, the molecular mechanisms underlying its structural organization, substrate recognition, and catalysis remain elusive. Here, we report the cryo-EM structure of human LPP2 (hLPP2). hLPP2 assembles as a homo-tetramer, with phosphatidylcholine bound in the substrate pocket. The tetrameric arrangement provides a structural basis for LPP oligomerization. The wide, open-ended substrate pocket explains the enzyme's broad substrate specificity. Structural comparison with PAP2 family members, including hG6PC1 and ecPgpB, suggests a conserved catalytic mechanism and highlights the regulatory role of residue E159 in stabilizing the catalytic center and phosphate release. Collectively, these findings advance our understanding of the structural basis and enzymatic mechanism of LPPs and may provide insights for the development of novel cancer therapies. - Source: PubMed
Publication date: 2026/05/01
Wang WanyiXu YueGuo PeilinHan HanHan Lei