Ask about this productRelated genes to: SEMG2 antibody
- Gene:
- SEMG2 NIH gene
- Name:
- semenogelin 2
- Previous symbol:
- -
- Synonyms:
- SGII
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-02
- Date modifiied:
- 2018-02-09
Related products to: SEMG2 antibody
Related articles to: SEMG2 antibody
- Serological screening, including immunological lateral flow assays, remains common for body fluid identification in sexual assault investigations but lacks the sensitivity and specificity of modern DNA profiling. To address this gap, alternative molecular approaches, including MS-based proteomics, have been explored. However, adoption is hindered by lengthy bottom-up workflows and reliance on research-grade instrumentation. Here, a streamlined, protease-free assay for the identification of saliva and seminal fluid in sexual assault evidence is described. Casework-type body fluid samples were extracted in a single step and analyzed by targeted DDA on a Q Exactive MS with a 25-min separation and data search using Byos software. The 96-well plate format used is amenable to higher-throughput automation. Discovery data sets included 50 saliva and 60 semen samples (including samples from 5 vasectomized males). This resulted in the identification of 7 saliva biomarkers (PRB1, PRB2, PRB4, PRH1, STATH, HTN1, and SMR3B) and 5 seminal fluid biomarkers (SEMG1, SEMG2, PSA, PAP, and PIP). Peptide standards were synthesized to confirm the discovery results and to develop a targeted assay. The method was successfully validated using 168 forensic casework-type samples, including diluted, laundered, and environmentally challenged samples on a variety of substrates. - Source: PubMed
Publication date: 2025/11/12
Brown Catherine OParker Glendon JWestring Christian GDanielson Phillip BLegg Kevin M - The proteome represents a valuable resource for identifying therapeutic targets and clarifying disease mechanisms in neurological disorders. This study investigated potential causal relationships between plasma proteins and postherpetic neuralgia (PHN). - Source: PubMed
Publication date: 2025/10/09
Wei QiuyuYu ShaoyongLuo YiSong XinghuiQin PinLi RongjiSun WeichaoWang JinWu Gang - Notable variations in semen parameters among non-smoking males have been documented post-COVID-19 pandemic. The role of smoking as a significant contributing factor to male infertility has been substantiated. Does the combined effect of smoking and SARS-CoV-2 infection impact male reproductive function? A prospective descriptive cohort study was performed using data from 90 smoking and 90 non-smoking males before and after coronavirus infection in a single center over a period of 3 months. Semen samples were collected before and within 15 days after COVID-19 infection, ensuring no more than three months elapsed between the two collections. The semen parameters evaluated included volume, concentration, progressive motility, normal morphology, and DNA fragmentation rate. Proteomic and metabolomic studies were further used to explore the differences between groups. Both non-smokers and smokers exhibited a marked reduction in sperm concentration, progressive motility, and normal morphology rate. Additionally, an increase in sperm DNA fragmentation index was noted for non-smokers and smokers. In the non-smoking group, dysregulation proteins including SEMG1, SEMG2 and DNAH5, and metabolites including L-glutamine, cis-9-Palmitoleic acid and Linoleamide were observed. In smokers, dysregulation proteins including SMCP, ROPN1B and IZUMO4, alongside metabolites including carnitine, gamma-Glutamylglutamic acid, and hypoxanthine were found. Comparative analysis between smoking and non-smoking patients post-COVID-19 also revealed significant differences in semen concentration, morphology and sperm DNA fragmentation rate. Dysregulated proteins including HSPA5, HSPA2 and PGK2, and metabolites such as acetylcarnitine, oxaloacetate and nicotinate were associated with impaired sperm function. Our study demonstrates that the virus also significantly compromises sperm quality in smoking males, who experience more pronounced declines post-infection compared to their non-smoking counterparts. This research underscores the necessity for comprehensive fertility assessments for smoking males after recovering from COVID-19. - Source: PubMed
Publication date: 2024/10/13
Wang ChengLuZhang JiaChengGao FangZheng MinFu XiaoHuaYang KeBing - There are big differences in treatments and prognosis between diabetic kidney disease (DKD) and non-diabetic renal disease (NDRD). However, DKD patients couldn't be diagnosed early due to lack of special biomarkers. Urine is an ideal non-invasive sample for screening DKD biomarkers. This study aims to explore DKD special biomarkers by urinary proteomics. - Source: PubMed
Publication date: 2024/02/01
Huang XinyingZhang HuiLiu JihongYang XuejiaoLiu Zijie - Exosome research is a current trend in functional proteomics as it provides important data on the pathophysiology and pathogenesis of diseases. The scientific outputs regarding these topics often only approach disease-protein/peptide/exosome or mechanismprotein/ peptide/exosome association. Approaching all three aspects could be the key to a better understanding of the pathophysiology and uncovering novel biomarkers for urogenital diseases. The focus of this work is to study exosome datasets to understand the possible role of underlying proteins in disease manifestation. We also attempt to link 4 different diseases that affect renal functions and are genetically inherited. - Source: PubMed
Perpétuo LuísThongboonkerd VisithFerreira RitaGuedes SofiaAmado FranciscoVitorino Rui