Ask about this productRelated genes to: Ambp antibody
- Gene:
- AMBP NIH gene
- Name:
- alpha-1-microglobulin/bikunin precursor
- Previous symbol:
- ITI, ITIL
- Synonyms:
- UTI, HCP, EDC1, HI30, IATIL, ITILC
- Chromosome:
- 9q32
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: Ambp antibody
Related articles to: Ambp antibody
- Intervertebral disc degeneration (IVDD) is a prominent etiology of lower back pain. Type 2 diabetes (T2D), the most prevalent metabolic disorder, may expedite IVDD progression through mechanisms involving hyperglycemia, advanced glycation end products, and microvascular complications. We aim to identify the biomarkers for T2D and IVDD. - Source: PubMed
Publication date: 2026/04/22
Qiu BaChen TaoHong QiXie XiaoxingXue MintaoXu NingShi ChangguiXu GuohuaWang WeihengSulaiman MuhammadXi Yanhai - Megalin, a multiligand endocytic receptor in proximal tubules (PTs), mediates the uptake of glomerular-filtered lipotoxic proteins, contributing to tubuloglomerular injury in high-fat diet (HFD)-fed mice. This process is characterized by pathologic vacuolation in PTs, which arises due to megalin-dependent autolysosomal dysfunction. Vacuolation is observed exclusively in segment 2 of PTs, which is vulnerable to metabolic stress because of its less robust endolysosomal system. Although receptor-mediated endocytosis (RME) predominates in segment 1, fluid-phase endocytosis (FPE) is more active in segment 2. This study investigates the effects of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, on HFD-induced autolysosomal dysfunction in PTs. In male kidney-specific conditional megalin-knockout mice, both RME and FPE in PTs were diminished compared with controls, as demonstrated by reduced uptake of fluorescent lysozyme and dextran, respectively. Similarly, in male C57BL/6J mice, 5-day dapagliflozin treatment suppressed uptake of both tracers in PTs compared with vehicle treatment, without affecting the glomerular filtration rate. Nine-week-old male C57BL/6J mice were fed an HFD and treated with dapagliflozin or vehicle for 28 days. Dapagliflozin significantly reduced cortical tubule vacuolation and urinary C-megalin excretion, another marker of autolysosomal metabolic overload and dysfunction in PTs. Urinary excretion of the megalin ligand α-microglobulin increased following dapagliflozin treatment via the suppression of megalin's endocytic function. However, renal megalin expression levels remained unchanged, as confirmed by immunoblotting, quantitative PCR, and immunohistochemistry. In conclusion, dapagliflozin alleviates HFD-induced, megalin-mediated autolysosomal dysfunction-particularly in segment 2 of PTs-likely by suppressing megalin-dependent RME and, more notably, FPE. Here, megalin was found to mediate both receptor-mediated and fluid-phase endocytosis in vivo. Dapagliflozin ameliorates high-fat diet-induced autolysosomal dysfunction-particularly in segment 2 of proximal tubules-likely by suppressing megalin-dependent endocytosis without altering megalin expression levels. This suppression reduces metabolic overload in proximal tubules, supporting a renoprotective role for dapagliflozin in chronic kidney disease. These findings highlight a novel mechanism by which dapagliflozin might protect against tubular injury in the context of metabolic stress. - Source: PubMed
Publication date: 2026/04/29
Takemoto KazuyaHosojima MichihiroKabasawa HideyukiKomochi KoichiAoki HiroyukiSugita NanakoGoto SawakoKaseda RyoheiNagatoishi SatoruTsumoto KouheiNarita IchieiYamamoto SuguruSaito Akihiko - Hypertension is a major modifiable risk factor for chronic kidney disease (CKD), yet predicting which hypertensive individuals will progress to CKD remains challenging. We aimed to develop and validate a plasma protein-based risk score for incident CKD in hypertension and to identify causal proteins and potential therapeutic targets. - Source: PubMed
Publication date: 2026/04/22
Huang YuChen DanYe ZiliangZhang YanjunYang SisiGan XiaoqinZhang YiweiWu YitingZhang YuanyuanQin Xianhui - Kidney function biomarkers are valuable early risk predictors for target organ injury (TOI), yet their prognostic value remains underexplored in young hypertensive adults. We aimed to determine whether baseline kidney biomarkers could predict TOI over 4.8-years in young adults, stratified by follow-up blood pressure status. - Source: PubMed
Publication date: 2026/03/05
Degenaar AnjaKruger RuanJacobs AdriaanMels Catharina M C - bacteraemia (SAB) is a common and severe infection, with a 90-day mortality of 24%-32%. Cloxacillin is regarded as a first-line antibiotic treatment in SAB in Sweden. However, exposure to cloxacillin in real-world hospitalised patients with SAB, most of whom are elderly patients treated outside the intensive care unit, is not well described. There are also limited data on the role of unbound cloxacillin exposure in relation to renal function or drug-induced toxicity. - Source: PubMed
Publication date: 2026/04/01
Damgaard TobiasHellborg ThomasLarsson AndersEliasson ErikBonnedahl JonasNielsen Elisabet ISchön ThomasHällgren Anita