Ask about this productRelated genes to: Masp2 antibody
- Gene:
- MASP2 NIH gene
- Name:
- mannan binding lectin serine peptidase 2
- Previous symbol:
- MASP1P1
- Synonyms:
- -
- Chromosome:
- 1p36.22
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-17
- Date modifiied:
- 2019-04-23
Related products to: Masp2 antibody
Related articles to: Masp2 antibody
- The complement system is a key component of innate immunity, critical for pathogen defense, inflammation, and immune regulation. Dysregulation or overactivation of complement pathways contributes to the pathogenesis of numerous kidney diseases, including atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy (C3G), membranous nephropathy, systemic lupus erythematosus (SLE), antiphospholipid antibody syndrome (APS), ANCA-associated vasculitis (AAV), diabetic nephropathy, and focal segmental glomerulosclerosis (FSGS). In these conditions, uncontrolled complement activation drives renal inflammation, microvascular injury, and fibrosis. - Source: PubMed
Publication date: 2026/04/10
Macciò LuciaRusso ElisaCostigliolo FrancescaBattaglia YuriViazzi FrancescaEsposito Pasquale - SLE is a systemic autoimmune disease in which the complement system plays a key pathogenic role, yet the contribution of the lectin pathway remains unclear. Lectin pathway-dependent complement activation is initiated by pattern-recognition molecules complexed with mannose-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated proteins (MAPs). Here, we combined biochemical and genetic analyses to explore associations between MASP/MAP proteins, SLE manifestations and autoantibody specificities. - Source: PubMed
Publication date: 2026/04/09
Lindelöf LinneaGarred PeterHong Mun-GwanWahl Vælum SashaHolten Petersen LotteLeonard DagSayadi AhmedOke VilijaNiewold Timothy BDiaz-Gallo Lina-MarcelaSaevarsdottir SaedisGunnarsson IvaSvenungsson ElisabetEriksson Oskar - Probiotics such as represent promising alternatives to antibiotics for combating enteric infections, yet their mechanisms of action remain incompletely understood. This study aimed to elucidate the protective mechanisms of CIQ249 against enteropathogenic bacterial infection, focusing on the intestinal physical barrier and mucosal immune responses. - Source: PubMed
Publication date: 2026/02/23
Gao XuwenZhou JiangfeiYan KaiGuan YuemingXiang JiayiLiu YimeiYu HanWang JingLi YuanXu Yigang - The complement system of vertebrates comprises classical, lectin, and alternative pathways, yet the evolutionary origin of the classical pathway remains unclear due to limited functional evidence for complement component C2 in early vertebrates. Common carp possesses two Bf/C2-like genes, B/C2-A and B/C2-B, but their functional assignments have not been fully established. In this study, we investigated whether B/C2-B represents a bona fide C2 by characterizing recombinant B/C2-B (rB/C2-B) expressed using a baculovirus/insect cell system. Western blotting confirmed that the recombinant protein corresponds to the endogenous serum molecule. Functional assays demonstrated that rB/C2-B does not participate in the assembly of the alternative pathway C3-convertase and shows minimal interaction with C3b-like C3i. In contrast, quartz crystal microbalance analyses revealed markedly higher affinity of rB/C2-B for C4b-like C4i. Moreover, rB/C2-B was cleaved by the carp MBL-MASP2 complex, generating a C2b-like fragment analogous to mammalian C2 activation in the lectin pathway. These findings collectively demonstrate that B/C2-B acts as functional C2 in carp, contributing to classical and lectin pathway activation but not to the alternative pathway. The results further indicate that Bf and C2 had already diverged by the time of bony fish evolution, supporting an early emergence of the classical pathway in vertebrate history. This study provides the first direct functional evidence for C2 in teleosts and refines our understanding of complement system evolution. - Source: PubMed
Publication date: 2026/03/06
Nakahara MakikoKato-Unoki YokoKimura MichiyoKizhakkumpat AkhilNagasawa TakahiroSomamoto TomonoriNakao Miki - Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, largely because of challenges in early diagnosis and the limited sensitivity of conventional biomarkers. Therefore, reliable molecular tools for early detection, prognostic stratification, and individualized treatment predictions are urgently required. - Source: PubMed
Publication date: 2026/03/04
Nguyen Tan ThinhNguyen Thanh DatNguyen Phu Qui LeBui Phuong ThiNguyen Minh Nam