Ask about this productRelated genes to: Igf2bp3 antibody
- Gene:
- IGF2BP3 NIH gene
- Name:
- insulin like growth factor 2 mRNA binding protein 3
- Previous symbol:
- -
- Synonyms:
- IMP-3, CT98, IMP3
- Chromosome:
- 7p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-09
- Date modifiied:
- 2015-11-23
Related products to: Igf2bp3 antibody
Related articles to: Igf2bp3 antibody
- Lymphatic dissemination is a major cause of treatment failure in muscle-invasive bladder cancer (MIBC), yet the RNA circuits linking post-transcriptional regulation to lymphatic metastasis remain incompletely defined. Here, we identify THAP7-AS1 as a predominantly cytoplasmic long noncoding RNA that is markedly upregulated in lymph node (LN) metastatic bladder cancer (BCa) and is associated with poor clinical outcome. Functionally, THAP7-AS1 promotes invasion and transendothelial migration in vitro and enhances LN metastasis in vivo. Mechanistically, THAP7-AS1 interacts with the mA reader IGF2BP3 and facilitates IGF2BP3 association with CCN2 mRNA, thereby promoting mA-dependent stabilization of CCN2 transcripts and increasing CCN2 protein abundance. Genetic depletion of IGF2BP3 or CCN2 abrogates THAP7-AS1-driven invasive and metastatic phenotypes, whereas CCN2 re-expression partially rescues the effects of THAP7-AS1 silencing. Collectively, these findings define a THAP7-AS1-IGF2BP3-mA-CCN2 axis that couples post-transcriptional mRNA stabilization to lymphatic metastasis and nominate THAP7-AS1 as a potential biomarker and therapeutic target in BCa. - Source: PubMed
Publication date: 2026/03/25
Li QiuyanBai JunjieZheng ShiwenLiao JiaxuanYang ZesongCai WanghaiLin JiexiangYe Liefu - Microvascular invasion (MVI) is a critical determinant of early recurrence and poor prognosis in hepatocellular carcinoma (HCC). The cellular and molecular mechanisms driving MVI, particularly the role of endothelial heterogeneity, remain incompletely understood. - Source: PubMed
Publication date: 2026/04/01
Zhang XinglongFu HuarongLu Jun - Alzheimer's disease (AD) is a complex neurological ailment that is associated with memory loss, confusion, and mood disturbances. Genetic, molecular, and cellular factors, including oxidative stress, inflammation, neurotransmitter alterations, and amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs), are associated with the disease. These can be associated with protein and DNA damage, mitochondrial dysfunction, energy shortages, inflammation, and hippocampal neuron death. Circular non-coding RNAs (circRNAs) are covalently closed and essential to many physiological and pathological processes. CircRNA may be a molecular modulator of neurodegeneration, as it may influence protein transcription and interaction with essential RNA-binding proteins (RBP) in the cortical and hippocampal regions, particularly in photoreceptor neurons and white matter.Insulin-like Growth Factor 2 mRNA-Binding Protein 3. (IGF2BP3), which belongs totheinsulin-like growth factor 2 encoded mRNA-binding protein family, affects neuronal differentiation, synaptic plasticity, translation, localization, mRNA stability, and neurogenesis. Research indicates that IGF2BP3 has been reported to modulate neuron survival and function genes, as well as BACE1 translation, which creates Aβ. AD has a complex etiology; thus, understanding its molecular processes is crucial. Investigating circRNAs and IGF2BP3 activities may reveal new disease are associated with and therapy options. This review explores the emerging roles ofcircRNAs as diagnostic biomarkers and potential therapeutic targets inmanagingAD. - Source: PubMed
Publication date: 2026/04/16
Firdous Sayed MohammadJayathilaka Sinhapurage Navodi SandaminiMarick SouvikPorel Pratyush - Buffaloes are vital livestock in South-East Asia, attributed to their adaptation to hot and humid climates as well as their capacity to produce high-quality milk and meat. However, the texture of buffalo meat is suboptimal and its slow growth rate restricts the development of the buffalo farming industry. Consequently, studies exploring the key biochemical factors associated with buffalo muscle development have become a research focus. CircRNAs are a class of non-coding RNAs which can function as molecular sponges, participate in protein scaffold formation, and encode short peptides. Previous studies have shown that circRNAs are capable of regulating muscle development; however, relatively few reports have addressed their association with buffalo muscle development. In this study, data from Western blotting and RT-qPCR showed that circCOPS8 significantly enhanced the differentiation of buffalo myoblasts while inhibiting their proliferation ( < 0.05). In contrast, in a mouse model of muscular injury, circCOPS8 prevented the repair of injured muscles. Additionally, RIP-qPCR assays confirmed that circCOPS8 could bind to IGF2BP3 ( < 0.05). Furthermore RT-qPCR and transcriptome sequencing results revealed that circCOPS8 inhibited cell growth by upregulating the expression of genes such as ATR ( < 0.05). Our findings suggested that circCOPS8 promoted the differentiation and apoptosis of buffalo myoblasts while inhibiting their proliferation. The inhibition of cell proliferation was primarily mediated by the binding of circCOPS8 to IGF2BP3 and the promotion of ATR gene expression. This study investigated the role and underlying mechanism of circCOPS8 in buffalo myoblasts, which will extend our understanding of non-coding RNA-mediated regulation of buffalo muscle development, with the ultimate goal of improving the meat quality of buffaloes. - Source: PubMed
Publication date: 2026/03/26
Dou YutingSun PingCheng XiangpingChen MengjieLi XinxinHuang JiepingLi ZhipengLiu QingyouShi DeshunLi HuiWang Jian - Osteosarcoma (OS) is the most common primary bone malignancy with an incompletely understood pathogenesis. The RNA-binding protein (RBP) insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 3 (IGF2BP3) has been implicated in various cancers, but its role and underlying mechanisms in OS have not been fully elucidated. This study aimed to investigate the molecular function of IGF2BP3 in OS progression and elucidate its mechanisms. - Source: PubMed
Publication date: 2026/03/24
Wu JingbinXia JiahaoTao YuanWeng Yiping