Ask about this productRelated genes to: Prmt7 antibody
- Gene:
- PRMT7 NIH gene
- Name:
- protein arginine methyltransferase 7
- Previous symbol:
- -
- Synonyms:
- FLJ10640, KIAA1933
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-16
- Date modifiied:
- 2014-11-18
Related products to: Prmt7 antibody
Related articles to: Prmt7 antibody
- Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity with evidence of contributions from multiple genetic factors, but the molecular basis of gene-gene interactions in its development remains unclear. Filamin B (FLNB) and tetratricopeptide repeat domain 26 (TTC26) have both been implicated in the regulation of primary cilia and extracellular matrix homeostasis. However, whether combined variation in these genes contributes to spinal instability has not been established. - Source: PubMed
Publication date: 2026/05/25
Jiang HengGao YuanLai BowenWu JinhuiLiao TaotaoZhang ZhengZhou XinZhao JianquanMeng YichenCai ZhuyunZhang ChenglinLai SuomeiGao RuiWang CeLi JinsongYang FuDing YifuZhou Xuhui - Protein arginine methyltransferases (PRMTs) are appealing therapeutic targets due to their critical roles in regulating numerous cellular processes and their dysregulation in various diseases. Although SAH-based inhibitors effectively target PRMTs, achieving selectivity across different methyltransferases remains a significant challenge. Herein, we employed a hybrid strategy that incorporates optimal linker length and "T-shape" modifications to enhance inhibitor selectivity. Starting with a selective PRMT7 inhibitor SGC8158 (IC <2.5 nM), we successfully transformed it into a selective PRMT4 inhibitor AK442 (IC = 2.6 nM). This approach highlights the potential of these design strategies to tune inhibitor selectivity, facilitating the development of isoform-specific PRMT inhibitors from existing scaffolds. - Source: PubMed
Publication date: 2026/05/01
Kulkarni Akshay SDeng YouchaoNam Hye SeungZhao TianqiMasal Dattatraya PBush Marlyn MichelleNoinaj NicholasHuang Rong - The underlying mechanism of recurrent pregnancy loss (RPL) is still not fully understood. We aimed to identify the key genes involved in the process by which obesity influences RPL. - Source: PubMed
Publication date: 2026/04/21
Mi HaixiaZhao LinglingGuo Junhong - Glutamine metabolism has emerged as an essential metabolic driver of tumor progression. Glutamate dehydrogenase 1 (GLUD1), a key enzyme in glutaminolysis, is frequently overexpressed in malignancies. Post-translational modifications (PTMs) are crucial for regulating protein function and tumor progression. However, the PTMs of GLUD1, particularly arginine methylation, remain unexplored. Here we report that protein arginine methyltransferase 7 (PRMT7) mediates monomethylation of GLUD1 at arginine 76 (R76), enhancing its protein stability by antagonizing ubiquitin-dependent degradation. Moreover, high glucose destabilizes GLUD1 via the PI3K/Akt pathway. Mechanistically, AKT1 phosphorylates PRMT7 at threonine 73 (T73) and promotes its activity to stabilize GLUD1 by increasing its methylation and reducing ubiquitination. Clinical analysis reveals that elevated GLUD1, PRMT7, and meGLUD1(R76) levels correlate with tumor progression in gastric cancer. In xenograft models, PRMT7 inhibitor SGC3027 combined with chemotherapeutic drugs docetaxel (DTX) synergistically suppresses tumor growth. Collectively, this study identifies the AKT1-PRMT7-GLUD1 axis as a key regulatory pathway in gastric cancer, and highlights its potential as a therapeutic target. - Source: PubMed
Publication date: 2026/03/24
Cui ZiyiLi HongchenLiang XiaobenZhao XinyuXu KaiLu YaoZhang YanLi XiaWu SiyaoWang ZhenLv LeiXu Yanping - The arginine methyltransferase 7 () gene plays a role in signal transduction and protein interactions and negatively regulates neuronal differentiation. Pathogenic variants of cause SBIDDS syndrome (Short stature, brachydactyly, intellectual developmental disability, and seizures). has been shown to interact with the argininosuccinate synthetase () gene; biallelic pathogenic variants of are associated with citrullinemia type 1. We report a patient with biallelic variants for SBIDDS syndrome and citrullinemia type 1. - Source: PubMed
Publication date: 2026/02/27
Boeri SilviaSiri LauraMartinez Popple MarinaCapra ValeriaRomano FerruccioFedi CaterinaNobili Lino