Ask about this productRelated genes to: JAZF1 antibody
- Gene:
- JAZF1 NIH gene
- Name:
- JAZF zinc finger 1
- Previous symbol:
- -
- Synonyms:
- TIP27, DKFZp761K2222, ZNF802
- Chromosome:
- 7p15.2-p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-10-05
- Date modifiied:
- 2018-02-13
Related products to: JAZF1 antibody
Related articles to: JAZF1 antibody
- Soft tissue sarcomas (STS) exhibit profound molecular heterogeneity. While recurrent gene fusions hold significant diagnostic and therapeutic value-guiding treatment selection and identifying novel molecular targets-our understanding of their broader clinical implications remains limited. - Source: PubMed
Publication date: 2026/04/27
Remiszewski PiotrBobak KlaudiaPiątkowski JakubGolik PawełTysarowski AndrzejSeliga KatarzynaSpałek Mateusz JSzumera-Ciećkiewicz AnnaWągrodzki MichałRutkowski PiotrCzarnecka Anna M - The relationships among obesity, accelerated biological aging, and asthma, as well as the underlying epigenetic mechanisms, remain incompletely understood. - Source: PubMed
Publication date: 2026/05/21
Liu JianSong ZhengqiShi ChenggeLu XinanZhang AijunChen YiheZhang Xuejia - Extra-uterine endometrial stromal sarcoma (EESS) is a rare mesenchymal tumour, and primary gastric involvement represents an exceptionally unusual presentation. Because such tumours present as ulcerated submucosal masses, they are easily misdiagnosed as gastrointestinal stromal tumours (GIST), making accurate, timely recognition critical for appropriate management. A 53-year-old woman presented with a five-day history of epigastric pain, low-grade fever, and malaise. Computed tomography (CT) imaging revealed an 11 cm vascular mass on the greater curvature of the stomach with splenic-hilum and transverse-colon contact, without evidence of local invasion. Upper gastrointestinal endoscopy revealed a friable ulcerated lesion, and biopsies suggested a spindle-cell neoplasm favouring GIST. At laparotomy, the tumour was found to infiltrate the stomach, splenic hilum, colon serosa, and omentum. An en bloc partial gastrectomy, splenectomy, segmental colectomy, cholecystectomy, and omentectomy were performed; final pathology showed microscopic involvement of the gastric radial soft-tissue margin. Histology demonstrated a primary gastric low-grade ESS with a vascular pattern and low mitotic index, while immunohistochemistry showed diffuse CD10/ER/PR positivity and absence of c-KIT, DOG-1, desmin, S100, SOX10, and STAT6, excluding GIST, leiomyosarcoma, PEComa, solitary fibrous tumour, and schwannoma. Targeted RNA-based sequencing identified a canonical JAZF1::SUZ12 fusion, confirming low-grade EESS. Given the tumour's low-grade, hormone-receptor-positive biology and microscopic radial margin involvement, adjuvant endocrine therapy with letrozole (2.5 mg daily) was initiated. At the six-month follow-up, the patient remained asymptomatic with no radiological evidence of recurrence. Primary gastric ESSS remains an exceptional finding and is easily mistaken for GIST. Accurate diagnosis and optimal management depend on comprehensive histology and immunohistochemistry, supported by fusion-gene testing, to guide individualised surgical and adjuvant management. Given the tumour's potential for very late relapse, prolonged surveillance is warranted despite the favourable short-term outcome. - Source: PubMed
Publication date: 2026/03/23
Mylonakis AdamKyros EleandrosKarakeke MariaKarakeke EleniPanagakis AndreasKastanaki PagonaKarydakis LysandrosPergaris AlexandrosSakellariou StratigoulaPapalampros Alexandros - The genetic basis of cardiovascular-kidney-metabolic syndrome (CKMs) involves complex pleiotropy, necessitating analytical approaches capable of dissecting shared genetic architectures across multiple cardiometabolic traits. - Source: PubMed
Lu ChuanlongLi LizhengChen JinshanChang RunzeDong Honglin - The spectrum of causal variants, mechanisms, and immunologic gene networks that influence pediatric atopic traits are not completely understood. Human genetic variation associated with transcript abundance (eQTLs) can help to advance our understanding, yet prior work has focused on profiling immune cell populations collected from peripheral blood primarily in adult populations, leaving uncharacterized tissue-resident lymphocytes collected from children. Here, we paired genotyping with gene expression profiling across four populations of tonsil-derived immune cell types - including previously uncharacterized germinal center B cells - collected from 103 children across development (ages 1-18). Using these data, we report cell-type specific gene networks and identify 13,393 eGenes (1,793 eGenes not previously reported in similar datasets) influenced by 27,603 eQTLs (5,199 not previously reported). We link discovered eQTLs to associations identified in pediatric and adult asthma and atopy traits, nominating 78 eGenes like , and in disease relevant cell types. Our resource is freely available and exemplifies the importance of discovery in native tissues and across human development. - Source: PubMed
Publication date: 2026/03/17
Lorenz KimYoon SamuelLe Coz CaroleZur KarenWells AndrewRomberg NeilVoight Benjamin F