Ask about this productRelated genes to: ZNF366 antibody
- Gene:
- ZNF366 NIH gene
- Name:
- zinc finger protein 366
- Previous symbol:
- -
- Synonyms:
- FLJ39796
- Chromosome:
- 5q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-29
- Date modifiied:
- 2015-08-26
Related products to: ZNF366 antibody
Related articles to: ZNF366 antibody
- Breast cancer comprises distinct molecular subtypes, including HER2-enriched, Luminal A, Luminal B, and triple-negative breast cancer (TNBC), each driven by distinct transcriptional programs and clinical behavior. However, the regulatory roles of zinc-finger transcription factors (ZNFs) underlying these subtype-specific programs remain incompletely defined. We performed a systematic RNA-sequencing-based comparative transcriptomic analysis across all major subtypes, incorporating differential expression analysis, pathway enrichment, protein-protein interaction network reconstruction, promoter motif scanning, and exploratory variant analysis to infer ZNF-centered regulatory architectures. HER2⁺ and Luminal B tumors exhibited the highest degree of transcriptional disruption, whereas Luminal A displayed comparatively limited deregulation. This analysis identified four subtype-specific ZNF hubs, MAZ (TNBC), ZNF596 (HER2⁺), ZNF366 (Luminal B), and ZNF671 (Luminal A), forming compact regulatory modules supported by promoter motif enrichment, indicative of putative transcription factor binding potential. Cross-subtype pathway analysis revealed conserved enrichment of Krüppel-associated box (KRAB) zinc-finger-mediated repression of endogenous retroelements, suggesting a shared epigenetic mechanism of transcriptional control. Interpretation is bounded by transcriptome-based regulatory inference without functional perturbation and by the absence of longitudinal or treatment-response data, limiting definitive causal attribution. Nonetheless, these findings establish a structured regulatory framework highlighting ZNF-driven transcriptional hierarchies across breast cancer subtypes. - Source: PubMed
Publication date: 2026/02/17
Ali MuhammadSaqib ManahilAli ZaeemRashid Sajid - Genetic control of gene expression in asthma-related tissues is not well characterized, particularly for African-ancestry populations, limiting advancement in our understanding of the increased prevalence and severity of asthma in these populations. - Source: PubMed
Publication date: 2025/09/08
Slack Sarah DEsquinca ErikaArehart Christopher HBoorgula Meher PreethiSzczesny BrookeRomero AlexCampbell MonicaChavan SameerRafaels NicholasWatson HaroldLandis R CliveHansel Nadia NRotimi Charles NOlopade Christopher OFigueiredo Camila AOber CaroleLiu Andrew HKenny Eimear EKammers KaiRuczinski IngoTaub Margaret ADaya MichelleGignoux Christopher RKechris KaterinaBarnes Kathleen CMathias Rasika AJohnson Randi K - Heart failure (HF) is the most common complication following myocardial infarction (MI) and frequently occurs during the postinfarction recovery phase. Despite the well-established association between HF and MI, the underlying molecular mechanisms driving their transition remain poorly understood. - Source: PubMed
Publication date: 2025/06/23
Xu JingyaDong ZhonghuaLi ZhaodongWang Xuan - Genetic control of gene expression in asthma-related tissues is not well-characterized, particularly for African-ancestry populations, limiting advancement in our understanding of the increased prevalence and severity of asthma in those populations. - Source: PubMed
Publication date: 2025/02/08
Slack Sarah DEsquinca ErikaArehart Christopher HBoorgula Meher PreethiSzczesny BrookeRomero AlexCampbell MonicaChavan SameerRafaels NicholasWatson HaroldLandis R CliveHansel Nadia NRotimi Charles NOlopade Christopher OFigueiredo Camila AOber CaroleLiu Andrew HKenny Eimear EKammers KaiRuczinski IngoTaub Margaret ADaya MichelleGignoux Christopher RKechris KaterinaBarnes Kathleen CMathias Rasika AJohnson Randi K - Tibetan pigs are indigenous to the Qinghai-Tibet Plateau and have been the subject of extensive genomic research primarily focused on their adaptation to high altitudes. However, genetic modifications associated with their response to low-altitude acclimation have not been thoroughly explored. To investigate the genetic basis underlying the low-altitude acclimation of Tibetan pigs, we generated and analyzed genotyping data of Tibetan pigs that inhabit high-altitude regions (average altitude 4000 m) and Tibetan pigs that have inhabited nearby low-altitude regions (average altitude 500 m) for approximately 20 generations. We found that the highland and lowland Tibetan pigs have distinguishable genotype and phenotype variations. We identified 46 and 126 potentially selected SNPs associated with 29 and 56 candidate genes in highland and lowland Tibetan pigs, respectively. Candidate genes in the highland Tibetan pigs were involved in immune response ( and ) and radiation (), whereas candidate genes in the lowland Tibetan pigs were related to reproduction (, , and ), growth and development (, , and ), and blood pressure regulation (). These findings will help to understand the mechanisms of environmental adaptation in Tibetan pigs and offer valuable information into the genetic improvement of Tibetan pigs pertaining to low-altitude acclimation and economic traits. - Source: PubMed
Publication date: 2024/02/19
Liu PengliangLiang YanLi LiLv XuebinHe ZhipingGu Yiren