Ask about this productRelated genes to: ZNF366 antibody
- Gene:
- ZNF366 NIH gene
- Name:
- zinc finger protein 366
- Previous symbol:
- -
- Synonyms:
- FLJ39796
- Chromosome:
- 5q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-29
- Date modifiied:
- 2015-08-26
Related products to: ZNF366 antibody
Related articles to: ZNF366 antibody
- Although immunotherapy has transformed the treatment landscape for many types of cancer, its therapeutic efficacy in glioblastoma (GBM) is limited by insufficient antigen presentation and the immunogenic cell exclusion in the tumor microenvironment. Here, we develop a candidate-based CRISPR activation (CRISPRa) functional screen to identify regulators of conventional dendritic cell (cDC)-fate specification. We determine that the transcription factors Zfp366/Znf366, Pu.1, Irf8, and Batf3 (ZPIB) are sufficient to convert GBM cells into cDC-like cells. ZPIB-mediated reprogramming results in global transcriptional and epigenetic remodeling in glioma cells. Single-cell RNA sequencing (scRNA-seq) profiling also reveals efficient and dynamic reprogramming of GBM cells to cDCs in vivo. Moreover, reprogrammed tumor cells remodel the microenvironment and elicit systemic tumor-eradicating and durable antitumor immunity in multiple mouse GBM models. Antitumor immunity elicited by ZPIB-DCs is synergistic with immune checkpoint inhibitors. Finally, we evaluate the clinical applicability of this approach by generating ZPIB-DCs from GBM patients within a humanized model. Our study represents a cellular reprogramming therapeutic strategy with broad implications for clinical immunotherapy. - Source: PubMed
Publication date: 2026/09/01
Liu XiaoZhu MaorongZou ChengCao ZhengcongWang YawenYang GuangzhaoLiu XiaolinWu YuxinYu DuoZheng DanZhang KuoLi JuanZhang WangqianWang ShuningQin HaozheHao QiangZhang YingqiYin AnanHe YalongHe LeiLuo XiaonanLin WeiLi MengGu Jintao - Breast cancer comprises distinct molecular subtypes, including HER2-enriched, Luminal A, Luminal B, and triple-negative breast cancer (TNBC), each driven by distinct transcriptional programs and clinical behavior. However, the regulatory roles of zinc-finger transcription factors (ZNFs) underlying these subtype-specific programs remain incompletely defined. We performed a systematic RNA-sequencing-based comparative transcriptomic analysis across all major subtypes, incorporating differential expression analysis, pathway enrichment, protein-protein interaction network reconstruction, promoter motif scanning, and exploratory variant analysis to infer ZNF-centered regulatory architectures. HER2⁺ and Luminal B tumors exhibited the highest degree of transcriptional disruption, whereas Luminal A displayed comparatively limited deregulation. This analysis identified four subtype-specific ZNF hubs, MAZ (TNBC), ZNF596 (HER2⁺), ZNF366 (Luminal B), and ZNF671 (Luminal A), forming compact regulatory modules supported by promoter motif enrichment, indicative of putative transcription factor binding potential. Cross-subtype pathway analysis revealed conserved enrichment of Krüppel-associated box (KRAB) zinc-finger-mediated repression of endogenous retroelements, suggesting a shared epigenetic mechanism of transcriptional control. Interpretation is bounded by transcriptome-based regulatory inference without functional perturbation and by the absence of longitudinal or treatment-response data, limiting definitive causal attribution. Nonetheless, these findings establish a structured regulatory framework highlighting ZNF-driven transcriptional hierarchies across breast cancer subtypes. - Source: PubMed
Publication date: 2026/02/17
Ali MuhammadSaqib ManahilAli ZaeemRashid Sajid - Genetic control of gene expression in asthma-related tissues is not well characterized, particularly for African-ancestry populations, limiting advancement in our understanding of the increased prevalence and severity of asthma in these populations. - Source: PubMed
Publication date: 2025/09/08
Slack Sarah DEsquinca ErikaArehart Christopher HBoorgula Meher PreethiSzczesny BrookeRomero AlexCampbell MonicaChavan SameerRafaels NicholasWatson HaroldLandis R CliveHansel Nadia NRotimi Charles NOlopade Christopher OFigueiredo Camila AOber CaroleLiu Andrew HKenny Eimear EKammers KaiRuczinski IngoTaub Margaret ADaya MichelleGignoux Christopher RKechris KaterinaBarnes Kathleen CMathias Rasika AJohnson Randi K - Heart failure (HF) is the most common complication following myocardial infarction (MI) and frequently occurs during the postinfarction recovery phase. Despite the well-established association between HF and MI, the underlying molecular mechanisms driving their transition remain poorly understood. - Source: PubMed
Publication date: 2025/06/23
Xu JingyaDong ZhonghuaLi ZhaodongWang Xuan - Genetic control of gene expression in asthma-related tissues is not well-characterized, particularly for African-ancestry populations, limiting advancement in our understanding of the increased prevalence and severity of asthma in those populations. - Source: PubMed
Publication date: 2025/02/08
Slack Sarah DEsquinca ErikaArehart Christopher HBoorgula Meher PreethiSzczesny BrookeRomero AlexCampbell MonicaChavan SameerRafaels NicholasWatson HaroldLandis R CliveHansel Nadia NRotimi Charles NOlopade Christopher OFigueiredo Camila AOber CaroleLiu Andrew HKenny Eimear EKammers KaiRuczinski IngoTaub Margaret ADaya MichelleGignoux Christopher RKechris KaterinaBarnes Kathleen CMathias Rasika AJohnson Randi K