Ask about this productRelated genes to: ZNF645 antibody
- Gene:
- CBLL2 NIH gene
- Name:
- Cbl proto-oncogene like 2
- Previous symbol:
- ZNF645
- Synonyms:
- FLJ25735, HAKAIL, CT138
- Chromosome:
- Xp22.11
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-16
- Date modifiied:
- 2018-01-19
Related products to: ZNF645 antibody
Related articles to: ZNF645 antibody
- Myopia, or nearsightedness, is highly prevalent in Asian countries and is considered a serious public health issue globally. High-grade myopia can predispose individuals to myopic maculopathy, premature cataracts, retinal detachment, and glaucoma. A recent study implicated zinc finger protein 644 isoform 1 (ZNF644) variants with non-syndromic high-grade myopia in a Chinese-Asian population. Herein we focused on investigating the role for ZNF644 variants in high-grade myopia in a United States (US) cohort. - Source: PubMed
Publication date: 2012/04/12
Tran-Viet Khanh-NhatSt Germain ElizabethSoler VincentPowell CaldwellLim Sing-HuiKlemm ThomasSaw Seang MeiYoung Terri L - A large number of testis-specific genes are involved in the complex process of mammalian spermatogenesis. Identification of these genes and their roles is important for understanding the mechanisms underlying spermatogenesis. Here we report on a novel human RING finger protein, ZNF645, which contains a C3HC4 RING finger domain, a C2H2 zinc-finger domain, and a proline-rich region, indicating that it has a structure similar to that of the c-Cbl-like protein Hakai. ZNF645 was exclusively expressed in normal human testicular tissue. Immunohistochemical analysis confirmed that ZNF645 protein was present in spermatocytes, round and elongated spermatids, and Leydig cells. Immunofluorescence staining of mature sperms further showed that the ZNF645 protein was localized over the postacrosomal perinuclear theca region and the entire length of sperm tail. An in vitro ubiquitination assay indicated that the RING finger domain of the ZNF645 protein had E3 ubiquitin ligase activity. Therefore, we suggest that ZNF645 might act as an E3 ubiquitin-protein ligase and play a role in human sperm production and quality control. - Source: PubMed
Publication date: 2010/07/26
Liu Yun-QiangBai GangZhang HaoSu DanTao Da-ChangYang YuanMa Yong-XinZhang Si-Zhong - Cancer/testis (CT) antigens exhibit highly tissue-restricted expression and are considered promising targets for cancer vaccines. Here we identified a novel CT gene ZNF645 which restrictively expresses in normal human testes and lung cancer patients (68.3%). To investigate the promoter methylation status of ZNF645, we carried out bisulfite genomic sequencing and found that the CpG island in its promoter was heavily methylated in normal lung tissues without the expression of ZNF645, whereas there was high demethylation in normal human testes and lung carcinoma tissues with its expression. Also ZNF645 could be remarkably activated in A549 and HEK293T cells treated by DNA demethylation agent 5'-aza-2'-deoxycytidine. And the dual luciferase assay revealed that the promoter activity of the ZNF645 was inhibited by methylation of the CpG island region. Therefore, we proposed that ZNF645 is a CT gene and activated in human testis and lung cancers by demethylation of its promoter region. - Source: PubMed
Bai GangLiu YunqiangZhang HaoSu DanTao DachangYang YuanMa YongxinZhang Sizhong