Ask about this productRelated genes to: SLC26A10 antibody
- Gene:
- SLC26A10 NIH gene
- Name:
- solute carrier family 26 member 10
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-25
- Date modifiied:
- 2016-10-05
Related products to: SLC26A10 antibody
Related articles to: SLC26A10 antibody
- (1) Background: Information regarding gene expression profiles and the prognosis of community-acquired pneumonia (CAP) is scarce. We aimed to examine the differences in the gene expression profiles in peripheral blood at hospital admission between patients with CAP who died during hospitalization and those who survived. (2) Methods: This is a multicenter study of nonimmunosuppressed adult patients who required hospitalization for CAP. Whole blood samples were obtained within 24 h of admission for genome-expression-profile analysis. Gene expression profiling identified both differentially expressed genes and enriched gene sets. (3) Results: A total of 198 samples from adult patients who required hospitalization for CAP were processed, of which 13 were from patients who died. Comparison of gene expression between patients who died and those who survived yielded 49 differentially expressed genes, 36 of which were upregulated and 13 downregulated. Gene set enrichment analysis (GSEA) identified four positively enriched gene sets in survivors, mainly associated with the interferon-alpha response, apoptosis, and sex hormone pathways. Similarly, GSEA identified seven positively enriched gene sets, associated with the oxidative stress, endoplasmic reticulum stress, oxidative phosphorylation, and angiogenesis pathways, in the patients who died. Protein-protein-interaction-network analysis identified , , , , , , , and as the main gene hubs. (4) Conclusions: We found differences in gene expression profiles at hospital admission between CAP patients who died and those who survived. Our findings may help to identify novel candidate pathways and targets for potential intervention and biomarkers for risk stratification. - Source: PubMed
Publication date: 2023/02/01
Viasus DiegoSimonetti Antonella FNonell LaraVidal OscarMeije YolandaOrtega LucíaArnal MagdalenaBódalo-Torruella MartaSierra MontserratRombauts AlexanderAbelenda-Alonso GabrielaBlanchart GemmaGudiol CarlotaCarratalà Jordi - Although previous genome-wide association studies (GWASs) have identified genetic susceptibility loci for abdominal adiposity, GWASs on Asian samples remain scarce. Therefore, we performed a GWAS for abdominal adipose tissue depots in a Korean population. - Source: PubMed
Publication date: 2022/04/26
Kim Hyun-JinSon Ho-YoungSung JoohonYun Jae MoonKwon HyuktaeCho BelongKim Jong-IlPark Jin-Ho - is a member of the SLC26 gene family, but its role in insects is still unclear. We cloned the gene of () and found contained 11 transmembrane regions and a STAS domain. Expression pattern analysis showed expression was more upregulated in adults than in nymphs, highest in the ovary. After injection of double-stranded RNA (dsRNA) of , the mRNA level of significantly decreased and, consequently, the ovarian development of adult females was hindered; the amount and the hatchability of eggs and yeast-like symbionts in mature oocytes decreased. Further study showed that might result in decreased juvenile hormone level and vitellogenin expression. These results indicate that plays an essential role in the reproduction of . - Source: PubMed
Publication date: 2022/03/17
Zhang RuijuanJi JinliangLi YabinYu JianbinYu XiaopingXu Yipeng - Nasal intestinal-type adenocarcinomas (ITAC) are strongly related to chronic wood dust exposure: The intestinal phenotype relies on CDX2 overexpression but underlying molecular mechanisms remain unknown. Our objectives were to investigate transcriptomic and methylation differences between healthy non-exposed and tumor olfactory cleft mucosae and to compare transcriptomic profiles between non-exposed, wood dust-exposed and ITAC mucosa cells. - Source: PubMed
Publication date: 2021/09/25
Gallet PatriceOussalah AbderrahimPouget CelsoDittmar GunnarChery CelineGauchotte GuillaumeJankowski RogerGueant Jean LouisHoulgatte Rémi - Many studies have analyzed the genes related to melanoma. However, only a limited number of studies have been conducted to identify the genes that are involved in the invasion and metastasis of acral melanoma (AM). Here, we attempted to investigate the genetic mutations associated with invasion and metastasis of AM. We analyzed five multi-regional samples of primary and metastatic AM and histologically normal tissue adjacent to the tumor (NAT) in two AM patients by whole-exome sequencing (WES). We identified single nucleotide variations and small indels present in tissue samples but not in saliva. We compared the sequencing results of superficial and deep lesions and primary and metastatic lesions of AM. We identified significantly deleterious mutations (SDM) that are likely to be related to invasion and metastasis of AM, respectively. SDM such as SKA3, MAST4, CNNM1, KIAA1549L, and SLC26A10 were found only in the deep lesion, but not in the superficial lesion. SDM present only in the metastatic lesion were ANO1, CPEB1, EP300, INADL, MAP1B, MAP7D1, MARCH6, NETO1, PRKCE, SBK1, TNRC6A, USP13, WDR74, and ZNF827. In conclusion, we applied multi-region WES to investigate possible pathogenic mutations related to invasion and metastasis in AM. Several genes including CNNM1, USP13, ZNF827, WDR74, CPEB1, and EP300 might be related to invasion and metastasis of AM. This study might facilitate the exploration of the evolutionary pathogenesis of advanced AM. - Source: PubMed
Publication date: 2021/04/23
Lim YoungkyoungLee Dong-Youn