Ask about this productRelated genes to: EGLN2 antibody
- Gene:
- EGLN2 NIH gene
- Name:
- egl-9 family hypoxia inducible factor 2
- Previous symbol:
- -
- Synonyms:
- PHD1, HIFPH1
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-21
- Date modifiied:
- 2016-05-03
Related products to: EGLN2 antibody
Related articles to: EGLN2 antibody
- Cardiac fibrosis can be triggered by several pathologies, including ischemic heart disease and aortic stenosis. Cardiac fibrosis is brought about by uncontrolled ECM (extracellular matrix) deposition by myofibroblasts. IL (interleukin)-11 () has been demonstrated as a trigger of multiorgan fibrosis. However, the molecular mechanisms underpinning IL-11-induced fibrosis require further characterization. Recent studies indicate that microRNA dysregulation contributes to the pathogenesis of cardiac fibrosis and can be targeted therapeutically. This study explored the hypothesis that microRNAs act as downstream effectors of IL-11-induced cardiac fibrosis. Moreover, we investigated the translational potential of IL-11-regulated microRNAs as circulating biomarkers of cardiac fibrosis in patients with aortic stenosis. - Source: PubMed
Publication date: 2026/03/17
Tikhomirov RomanBoichenko VeronikaReilly-O'Donnell BenedictLucarelli CarlaSrivastava Prashant KumarAnwar MaryamYiu Chi Him KendrickDielesen JuliaNoakes Victoria MariaPiella Santiago NicolasKazharova DianaLabbé MathildeKwan ZoeZaccagnini GermanaMansfield CatherineTessari MaddalenaMenicanti LorenzoGreco SimonaSweeney MarkOkafor JosephLeszek PrzemysławFaggian GiuseppeLuciani Giovanni BattistaEmanueli CostanzaMartelli FabioGorelik Julia - Efficient in vitro maturation (IVM) of mammalian oocytes is essential for breeding and genetic improvement of elite lines. However, porcine embryos generally show lower developmental potential than those of other species. Oocyte maturation and early embryonic development occur within a dynamically changing follicular microenvironment, in which hypoxia critically shapes developmental competence. Redox homeostasis in follicles is indispensable for oocyte development, yet how exosome-derived non-coding RNAs modulate oxidative-stress balance in porcine oocytes remains unclear. Here, high-throughput sequencing and bioinformatic analysis identified the long non-coding RNA (lncRNA) ENSSSCG00000049656 (lnc49656). We then characterized its function using dual-luciferase reporter assays, RNA immunoprecipitation (RIP), quantitative real-time PCR (qRT-PCR), and Western blotting (WB). Overexpressing lnc49656 significantly enhanced cumulus expansion, cleavage, and blastocyst formation (p < 0.05). Comparative cultures under different oxygen tensions showed that, under normoxia, lnc49656 overexpression significantly reduced expression of downstream HIF-1 target genes-Vascular Endothelial Growth Factor (VEGF), Lactate Dehydrogenase A (LDHA), and Glucose Transporter 1 (GLUT1) (p < 0.05); inhibiting lnc49656 or overexpressing ssc-miR-500-3p (miR-500) reversed these effects. Mechanistically, lnc49656 sequestered miR-500, thereby relieving miR-500-mediated repression of Egl nine homolog 2 (EGLN2). As a core component of the oxygen-sensing system, EGLN2 hydroxylates hypoxia-inducible factor-1α (HIF-1α) to promote its degradation, thereby affecting redox homeostasis in the follicular microenvironment. Collectively, these findings indicate that the lnc49656/miR-500/EGLN2 axis is a key regulator of hypoxic responses and oxidative-stress balance during porcine oocyte maturation and early embryonic development, offering a new perspective for dissecting the molecular mechanisms of the follicular microenvironment. - Source: PubMed
Publication date: 2026/01/21
Zhang JunzhengZhang YuyangLi HaoWang JieYao ZhiweiZhao KunAn YangYao ShunfaXu QinglongJi ShuangJin Yi - This corrects the article DOI:10.4149/neo_2025_250411N162. - Source: PubMed
Wu YueChen HaiyanJiang ShengyuanWu XiaoliLi DakeXie Kaipeng - Roxadustat is used for treating chronic kidney disease (CKD) patients, particularly those on hemodialysis with comorbid cancer. Some studies suggest a link between roxadustat and cancer progression, but the mechanisms remain unclear, highlighting the need for further investigation into potential causal links. - Source: PubMed
He XiaonaChen HongxiQi YueLong WenjieZhou YangangMa Xin - Growing evidence indicates that ferroptosis is pivotal in the development and progression of ovarian cancer (OC). However, the function of EGLN2 in OC remains unclear. In this study, we observed that EGLN2 is expressed at low levels in OC tissues and is associated with a favorable prognosis in early-stage patients based on data from TCGA and GTEx public databases. Compared with those in normal ovarian epithelial cell lines, EGLN2 mRNA and protein levels were significantly lower in OC cell lines. In vitro functional experiments revealed that EGLN2 overexpression reduced proliferation, increased the intracellular levels of iron ions, reactive oxygen species, lipid peroxidation, and mitochondrial oxidative phosphorylation, and inhibited the Warburg effect. Mechanistically, EGLN2 inhibited the expression of HIF-1α, which binds to the promoter of ceruloplasmin (CP), reducing the proliferation of and inducing ferroptosis in OC cells. A subcutaneous xenograft model in nude mice demonstrated that EGLN2 overexpression inhibited HIF-1α, promoted ferroptosis, and inhibited OC cell growth. In summary, EGLN2 suppressed CP transcription and increased ferroptosis in OC cells. These findings provide new insights into OC development and open avenues for innovative therapies. - Source: PubMed
Wu YueChen HaiyanJiang ShengyuanWu XiaoliLi DakeXie Kaipeng