Ask about this productRelated genes to: CPXCR1 antibody
- Gene:
- CPXCR1 NIH gene
- Name:
- CPX chromosome region candidate 1
- Previous symbol:
- -
- Synonyms:
- CT77
- Chromosome:
- Xq21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-02
- Date modifiied:
- 2019-01-21
Related products to: CPXCR1 antibody
Related articles to: CPXCR1 antibody
- Colon cancer is a serious public health issue and a major cause of cancer-related mortality worldwide, including Saudi Arabia. Knowledge of genes associated with colon cancer development and progression is essential for identifying new cancer-specific biomarkers to improve the diagnosis of colon cancer. - Source: PubMed
Publication date: 2023/12/14
Alrubie Turki MShaik Jilani PAlamri Abdullah MAlanazi MohammadAlshareeda Alaa TAlqarni AyyobAlawfi Homoud GAlmaiman Sarah MAlmutairi Mikhlid H - Loneliness and social isolation are detrimental to mental health and may lead to cognitive impairment and neurodegeneration. Although several molecular signatures of loneliness have been identified, the molecular mechanisms by which loneliness impacts the brain remain elusive. Here, we performed a bioinformatics approach to untangle the molecular underpinnings associated with loneliness. Co-expression network analysis identified molecular 'switches' responsible for dramatic transcriptional changes in the nucleus accumbens of individuals with known loneliness. Loneliness-related switch genes were enriched in cell cycle, cancer, TGF-β, FOXO, and PI3K-AKT signaling pathways. Analysis stratified by sex identified switch genes in males with chronic loneliness. Male-specific switch genes were enriched in infection, innate immunity, and cancer-related pathways. Correlation analysis revealed that loneliness-related switch genes significantly overlapped with 82% and 68% of human studies on Alzheimer's (AD) and Parkinson's diseases (PD), respectively, in gene expression databases. Loneliness-related switch genes, , , , , , , and have been identified as genetic risk factors for AD. Likewise, switch genes , , and are known genetic loci in PD. Similarly, loneliness-related switch genes overlapped in 70% and 64% of human studies on major depressive disorder and schizophrenia, respectively. Nine switch genes, , , , , , , , , and , overlapped with known genetic variants in depression. Seven switch genes, , , , , , , and were associated with known risk factors for schizophrenia. Collectively, we identified molecular determinants of loneliness and dysregulated pathways in the brain of non-demented adults. The association of switch genes with known risk factors for neuropsychiatric and neurodegenerative diseases provides a molecular explanation for the observed prevalence of these diseases among lonely individuals. - Source: PubMed
Publication date: 2023/03/21
Santiago Jose AQuinn James PPotashkin Judith A - GWAS discoveries on the X-chromosome are underrepresented in the literature primarily because the analytical tools that have been applied were originally designed for autosomal markers. Our objective here is to employ a new robust and flexible tool for chromosome-wide analysis of X-linked markers in complex traits. Orofacial clefts are good candidates for such analysis because of the consistently observed excess of females with cleft palate only (CPO) and excess of males with cleft lip with or without cleft palate (CL/P). - Source: PubMed
Publication date: 2017/09/06
Skare ØivindGjessing Håkon KGjerdevik MiriamHaaland Øystein ARomanowska JuliaLie Rolv TJugessur Astanand - . Increase in body weight is a gradual process that usually begins in childhood and in adolescence as a result of multiple interactions among environmental and genetic factors. This study aimed to analyze the relationship between copy number variants (CNVs) in five genes and four intergenic regions with obesity in Mexican children. . We studied 1423 children aged 6-12 years. Anthropometric measurements and blood levels of biochemical parameters were obtained. Identification of CNVs was performed by real-time PCR. The effect of CNVs on obesity or body composition was assessed using regression models adjusted for age, gender, and family history of obesity. . Gains in copy numbers of and were associated with decreased body mass index (BMI), waist circumference (WC), and risk of abdominal obesity, whereas gain in and and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d and losses in were associated with increased BMI and WC. . Our results indicate a possible contribution of CNVs in , , , and and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children. - Source: PubMed
Publication date: 2017/03/27
Antúnez-Ortiz Diana LizzeteFlores-Alfaro EugeniaBurguete-García Ana IsabelBonnefond AméliePeralta-Romero JesúsFroguel PhilippeEspinoza-Rojo MónicaCruz Miguel - Histopathological assessment has a low potential to predict clinical outcome in patients with the same stage of colorectal cancer. More specific and sensitive biomarkers to determine patients' survival are needed. We aimed to determine gene expression signatures as reliable prognostic marker that could predict survival of colorectal cancer patients with Dukes' B and C. - Source: PubMed
Publication date: 2016/09/08
Abdul Aziz Nurul AininMokhtar Norfilza MHarun RoslanMollah Md Manir HossainMohamed Rose IsaSagap IsmailMohd Tamil AzmiWan Ngah Wan ZurinahJamal Rahman