Ask about this productRelated genes to: CCNB3 antibody
- Gene:
- CCNB3 NIH gene
- Name:
- cyclin B3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xp11.22
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-30
- Date modifiied:
- 2016-10-05
Related products to: CCNB3 antibody
Related articles to: CCNB3 antibody
- Ewing family of tumors (EFT) encompass a group of small blue round cell tumors, including Ewing sarcoma (ES) and EWSR1-negative undifferentiated small round cell sarcoma. The distinction between the EFTs is essential from a clinical perspective due to prognostic and therapeutic differences and is substantiated by the advent of molecular testing in the modern era. In this study, we tried to characterize EFTs by using fluorescent in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR). - Source: PubMed
Publication date: 2026/03/30
Sable Mukund NAparnna J NPurkait Suvendu - The World Health Organization introduced substantial revisions in the 2020 fifth edition of the classification system for bone and soft-tissue tumors, reorganizing what were previously called the Ewing sarcoma family of tumors or Ewing-like sarcomas into a new category of "undifferentiated small round cell sarcomas" based on molecular genetic characteristics. This reclassification established four distinct entities: Ewing sarcoma (ES), -rearranged sarcoma, sarcoma with genetic alterations, and sarcoma with non fusion genes. Each subtype may demonstrate specific clinical, pathologic, and imaging features, with different treatment responses and prognoses. ES primarily affects children and young adults, with characteristic "moth-eaten" lytic bone destruction, aggressive periosteal reactions, and extensive surrounding soft-tissue masses. -rearranged sarcomas typically manifest as well-circumscribed lobulated soft-tissue masses with extensive internal necrosis and hemorrhage but no calcification. Sarcomas with genetic alterations commonly occur in adolescent boys as osteolytic or sclerotic lesions in the long bones or the pelvis, often with calcification in the extraosseous component. Sarcomas with non fusion genes may manifest as osteolytic lesions with cortical expansion and saucer-like surface erosion in long bone diaphyses. Radiologic recognition of -rearranged sarcomas enables oncologists to anticipate their aggressive nature and poor response to standard ES treatments, which may necessitate more intensive initial surgical interventions. In comparison, identifying sarcomas through imaging allows clinicians to inform patients of their potentially more favorable outcomes compared with those of ES while still applying appropriate comprehensive treatment approaches. The authors provide an overview of the clinical features, pathologic findings, imaging characteristics, differential diagnosis, and treatment outcomes of each entity. RSNA, 2026. - Source: PubMed
Mori KoichiroKurokawa RyoMotoi ToruKurokawa MarikoHirai ToshihideTakaki Yasunobu - Cyclin B3 (CCNB3) plays a critical regulatory role in mammalian meiosis. Studies in mice have demonstrated that CCNB3 interacts with CDK1 to modulate the activity of MPF, thereby driving meiotic progression. However, the functional mechanisms of CCNB3 in porcine oocytes remain unclear. In this study, we reveal for the first time that knockdown of CCNB3 in porcine oocytes induces meiotic arrest at metaphase I, accompanied by impaired degradation of cyclin B1 and securin. Further investigation identifies that the antisense long non-coding RNA CCNB3-AS forms a double-stranded RNA (dsRNA) structure with the CCNB3 mRNA, significantly enhancing its stability by resisting PAT1 homolog 1 (PATL1)-mediated degradation. Mechanistically, CCNB3-AS interacts with the scaffold protein Vimentin (VIM). Structural analysis reveals that VIM binds to the PAT1 domain of PATL1 and is capable of influencing the ability of CNOT7, the core subunit of the CCR4-NOT complex, to bind to PATL1, ultimately maintaining stable CCNB3 mRNA expression. Our study elucidates the molecular mechanism by which the CCNB3-AS/CCNB3 dsRNA duplex cooperates with VIM and PATL1 to collectively regulate meiosis in porcine oocytes. Furthermore, we reveal the non-canonical role of VIM in mRNA degradation, providing new theoretical support for understanding the mechanisms underlying porcine oocyte meiosis. - Source: PubMed
Publication date: 2026/03/24
Zhu YanlongJiang Xi-QingGao ShuangZhang Chen-YuanXie HongshuangYang QingboWang Zi-HaoChai ZhuangLiu ZhonghuaSun Jing-TaoHe TianyaoWang JiaqiangJin Jun-Xue - Pediatric adrenal tumors are uncommon, with the most common being peripheral neuroblastic tumors. Other neoplasms like adrenal cortical tumors, pheochromocytoma, and myelolipoma may also be encountered in this age group. Rare instances of mesenchymal tumors such as Ewing sarcoma and rhabdomyosarcoma have been described. We report the fine needle aspiration cytology (FNAC) findings of the first case of BCOR-altered sarcoma occurring in the adrenal gland. A 13-year-old boy presented with severe abdominal pain. Imaging revealed a mass in the right adrenal gland. FNAC showed loosely cohesive clusters and singly dispersed medium-sized polygonal to spindled tumor cells with scant to moderate delicate cytoplasm and normochromic, mildly pleomorphic nuclei with fine granular chromatin. Slender fibrovascular cores traversed tumor fragments. Histopathology of the adrenalectomy showed sheets of round to spindled tumor cells interrupted by thin fibrovascular septae, with foci of necrosis. BCOR, SATB2, and cyclin D1 were positive, while CD99, NKX2.2, WT1, desmin, and myogenin were negative. Fluorescence in situ hybridization revealed BCOR::CCNB3 fusion, consistent with BCOR-rearranged sarcoma. BCOR-rearranged sarcomas are rare malignant neoplasms. As primary treatment is chemotherapy, accurate diagnosis on limited material such as FNAC is critical. The recognition of cytological features and follow up with appropriate ancillary testing has the potential to improve management of these patients. - Source: PubMed
Publication date: 2026/02/24
Meet SimranKakkar AanchalSharma ShilpaJana ManishaIyer Venkateswaran K - Undifferentiated round cell sarcomas (URCSs) are tumors of bone and soft tissue that are heterogeneous in terms of driver events and diverse in their clinical course. - Source: PubMed
Publication date: 2026/02/05
Panferova AgnesaSinichenkova KseniaAbasov RuslanSidorov IlyaUsman NataliaChernev AlexeyLitvinov DmitryKarachunskiy AlexanderGrachev NikolaiDruy Alexander