Ask about this productRelated genes to: ZFYVE20 antibody
- Gene:
- RBSN NIH gene
- Name:
- rabenosyn, RAB effector
- Previous symbol:
- ZFYVE20
- Synonyms:
- -
- Chromosome:
- 3p25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-04-01
- Date modifiied:
- 2014-12-03
Related products to: ZFYVE20 antibody
Related articles to: ZFYVE20 antibody
- Early detection of sepsis is essential for its successful management. Although genome-wide association studies (GWAS) have shown potential in identifying sepsis-related genetic variants, they often involve heterogeneous patient groups and use single-locus analysis methods. Here, we aim to identify new sepsis susceptibility loci in post-surgical patients using an explainable artificial intelligence (XAI) approach applied to GWAS data. - Source: PubMed
Publication date: 2025/12/15
Vaquerizo-Villar FernandoHernandez-Beeftink TamaraHeredia-Rodríguez MaríaGómez-Sánchez EstherLorenzo-López MarioLópez-Herrero RocíoBardaji-Carrillo MiguelTamayo-Velasco ÁlvaroMartín-Fernández MartaSánchez-de-Prada LauraÁlvarez-Escudero JuliánVeiras SoniaBaluja AuroraGonzalo-Benito HugoMartínez-Paz PedroGarcía-Concejo AdriánFernández-Rodríguez AmandaJiménez-Sousa María AResino SalvadorMartínez-Campelo LauraSuárez-Pajés EvaQuintela InésCruz RaquelCarracedo ÁngelVillar JesúsFlores CarlosHornero RobertoTamayo Eduardo - Oxaliplatin (OXA) and 5-fluorouracil (5-Fu) are standard chemotherapy agents used to treat advanced gastric cancer (GC). However, their clinical efficacy is often limited by systemic toxicity, poor tumor selectivity, and suboptimal therapeutic outcomes when administered as monotherapy. These limitations underscore the need for innovative approaches to improve chemotherapy sensitivity and treatment efficacy. - Source: PubMed
Publication date: 2025/06/17
Ren JiannanSong MenglinDing DongbingLan TianyunLi YiquanLiang RongpuHuang ShengxinJiang GuangchunYou JiarongYang JianmingChen ChiLuan WeiyiAbdullaev BekhzodHuang HeZhao YangWei Bo - Metastasis, the primary cause of death in lung cancer patients, is facilitated by cytoskeleton remodeling, which plays a crucial role in cancer cell migration and invasion. However, the precise regulatory mechanisms of intracellular trafficking proteins involved in cytoskeleton remodeling remain unclear. In this study, we have identified Rabenosyn-5 (Rbsn) as an inhibitor of filopodia formation and lung cancer metastasis. Mechanistically, Rbsn interacts with CDC42 and functions as a GTPase activating protein (GAP), thereby inhibiting CDC42 activity and subsequent filopodia formation. Furthermore, we have discovered that Akt phosphorylates Rbsn at the Thr253 site, and this phosphorylation negates the inhibitory effect of Rbsn on CDC42 activity. Additionally, our analysis reveals that Rbsn expression is significantly downregulated in lung cancer, and this decrease is associated with a worse prognosis. These findings provide strong evidence supporting the role of Rbsn in suppressing lung cancer progression through the inhibition of metastasis. - Source: PubMed
Publication date: 2024/07/29
Guo XiongMu BinZhu LinZhuo YanliMu PingRen FuLu Fangjin - It is important to establish and clarify the relationship between stereochemically active lone pairs and birefringence, since it is one of the significantly effective routes to explore birefringent crystals by introducing Sn-centered polyhedra with stereochemically active lone pairs. Herein, four tin(II)-based ternary halides A SnCl and ASn Cl (A=NH and Rb) have been synthesized successfully. The experimental birefringence of Rb SnCl and RbSn Cl is larger than or equal to 0.046 and 0.123@546 nm, respectively. Through investigating the alkali or alkaline-earth metal tin(II)-based ternary halides, the structure-performance relationship has been concluded between stereochemically active lone pairs and optical anisotropy. It is beneficial to the analysis and prediction of birefringence in tin-based halides and provides a guide for exploring tin(II)-based optoelectronic functional materials. - Source: PubMed
Publication date: 2023/06/02
Guo JingyuHuang JunbenTudi AbudukadiHou XuelingHan ShujuanYang ZhihuaPan Shilie - Rabenosyn (RBSN) is a conserved endosomal protein necessary for regulating internalized cargo. Here, we present clinical, genetic, cellular and biochemical evidence that two distinct RBSN missense variants are responsible for a novel Mendelian disorder consisting of progressive muscle weakness, facial dysmorphisms, ophthalmoplegia and intellectual disability. Using exome sequencing, we identified recessively acting germline alleles p.Arg180Gly and p.Gly183Arg, which are both situated in the FYVE domain of RBSN. We find that these variants abrogate binding to its cognate substrate phosphatidylinositol 3-phosphate (PI3P) and thus prevent its translocation to early endosomes. Although the endosomal recycling pathway was unaltered, mutant p.Gly183Arg patient fibroblasts show accumulation of cargo tagged for lysosomal degradation. Our results suggest that these variants are separation-of-function alleles, which cause a delay in endosomal maturation without affecting cargo recycling. We conclude that distinct germline mutations in RBSN cause non-overlapping phenotypes with specific and discrete endolysosomal cellular defects. - Source: PubMed
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