Ask about this productRelated genes to: ZFYVE20 antibody
- Gene:
- RBSN NIH gene
- Name:
- rabenosyn, RAB effector
- Previous symbol:
- ZFYVE20
- Synonyms:
- -
- Chromosome:
- 3p25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-04-01
- Date modifiied:
- 2014-12-03
Related products to: ZFYVE20 antibody
Related articles to: ZFYVE20 antibody
- Metastatic cancer remains the leading cause of cancer-related mortality, yet tumor cell-intrinsic mechanisms restraining metastatic dissemination remain incompletely defined. Here, we perform an unbiased in vivo genome-wide CRISPR/Cas9 loss-of-function screen in a breast cancer xenograft model to identify regulators of metastatic progression. This approach uncovers clinically relevant metastasis suppressor genes (MSGs), including VPS45, CMTR2, RBSN, and NF2, whose loss enhances lung colonization. Functional validation demonstrates that depletion of these genes promotes epithelial-to-mesenchymal transition, migration, invasion, intravasation, and angiogenesis, whereas CRISPR-mediated activation suppresses metastatic spread. Integration with patient datasets reveals reduced expression in tumors and associations with advanced disease, with higher expression trending toward improved outcomes. Notably, CMTR2 loss induces vascular remodeling and intratumoral heterogeneity, supporting a role in tumor-vascular interactions. Collectively, this study identifies a network of MSGs that constrain tumor dissemination and highlights the power of in vivo CRISPR functional genomics to uncover regulators of metastatic disease. - Source: PubMed
Publication date: 2026/08/04
Galal SoaadChaltel Lima LeslieWang NiMoury CléoYan GangDai MeiouAli SuhadLebrun Jean-Jacques - Tunable fluorescence emission endows luminescent materials with immense applications in optoelectronic devices and information security. Herein, broad-wavelength photoluminescence (PL) tuning from yellow to white to blue is realized in a zero-dimensional (0D) K4CdCl6 halide via a facile Rb/Sn codoping strategy. Interestingly, K4CdCl6 and isostructural Rb4CdCl6 halides exhibit yellow and blue PL emissions via the homovalent doping of Sn2+, respectively. The relative intensity ratio of yellow and blue emission bands can be effectively regulated in K4CdCl6:Sn2+ halides by Rb+ alloying; accordingly, the continuous luminescence color tuning covering yellow, white, and blue spectral regions was successfully achieved. Density functional theory calculations further verify that the doping of Sn2+ leads to the appearance of an impurity energy level within the band gap, accelerates electronic transitions, and ultimately enhances PL emission efficiency. On the basis of this rationally designed tunable luminescent system, the three-level color-coded intelligent password devices, combining multimode optical anticounterfeiting and digital information encryption, were developed. This work not only develops a reliable ion doping strategy for luminescence modulation in the metal halides but also expands their diversified application prospects in advanced optoelectronic fields. - Source: PubMed
Zhang YanjiaoGong PifuChen MingxingWang ZhigangWang XinfangQi ManHan YunhuaJia ZhenXia Mingjun - Antibodies are known to prevent infection by binding to pathogens extracellularly and blocking their entry into cells. What is less well known is that a proportion of pathogens, called the persistent fraction, still succeed in entering cells despite the antibodies bound to their surface. Fortunately, all mammalian cells express a dedicated cytosolic antibody receptor called TRIM21 that intercepts these incoming antibody-bound pathogens as soon as they enter the cytosol. Once it has detected an infection event, TRIM21 uses its E3 ubiquitin ligase activity to target pathogens for degradation. Our early work showed that TRIM21-mediated neutralization was both a fast and efficient process, capable of causing the degradation of incoming viral particles within hours. What was less clear was how TRIM21 achieves this degradation. In a recent study, we reveal that TRIM21 mediates a system of selective autophagy to direct incoming pathogens into the lysosome.: TRIM21:Tripartite-motif containing protein 21; VCP: Valosin-Containing Protein. CRISPR: Clustered Regularly Interspaced Short Palindromic Repeats; FACS: fluorescence activated cell sorting; GFP: green fluorescent protein; LC3: Microtubule-associated Protein 1 Light Chain 3; TBK1: TANK-binding kinase 1; FIP200: FAK family kinase-interacting protein of 200 kDa; ULK1: Unc-51-like autophagy activating kinase 1; PI3K: Phosphoinositide 3-Kinase; ATG: autophagy-related gene; TMEM41B: transmembrane protein 41B; VPS37A: Vacuolar Protein Sorting-Associated Protein 37A; RBSN: Rabenosyn-5; EPG5: Ectopic P-Granules 5 Autophagy Tethering Factor; NDP52: Nuclear Dot Protein 52; ADX: antibody-dependent xenophagy; p62/SQSTM1: Protein 62/ Sequestosome 1; LPS: Lipopolysaccharide. - Source: PubMed
Publication date: 2026/07/22
Rhinesmith TAlbecka AJames L C - Early detection of sepsis is essential for its successful management. Although genome-wide association studies (GWAS) have shown potential in identifying sepsis-related genetic variants, they often involve heterogeneous patient groups and use single-locus analysis methods. Here, we aim to identify new sepsis susceptibility loci in post-surgical patients using an explainable artificial intelligence (XAI) approach applied to GWAS data. - Source: PubMed
Publication date: 2025/12/15
Vaquerizo-Villar FernandoHernandez-Beeftink TamaraHeredia-Rodríguez MaríaGómez-Sánchez EstherLorenzo-López MarioLópez-Herrero RocíoBardaji-Carrillo MiguelTamayo-Velasco ÁlvaroMartín-Fernández MartaSánchez-de-Prada LauraÁlvarez-Escudero JuliánVeiras SoniaBaluja AuroraGonzalo-Benito HugoMartínez-Paz PedroGarcía-Concejo AdriánFernández-Rodríguez AmandaJiménez-Sousa María AResino SalvadorMartínez-Campelo LauraSuárez-Pajés EvaQuintela InésCruz RaquelCarracedo ÁngelVillar JesúsFlores CarlosHornero RobertoTamayo Eduardo - Oxaliplatin (OXA) and 5-fluorouracil (5-Fu) are standard chemotherapy agents used to treat advanced gastric cancer (GC). However, their clinical efficacy is often limited by systemic toxicity, poor tumor selectivity, and suboptimal therapeutic outcomes when administered as monotherapy. These limitations underscore the need for innovative approaches to improve chemotherapy sensitivity and treatment efficacy. - Source: PubMed
Publication date: 2025/06/17
Ren JiannanSong MenglinDing DongbingLan TianyunLi YiquanLiang RongpuHuang ShengxinJiang GuangchunYou JiarongYang JianmingChen ChiLuan WeiyiAbdullaev BekhzodHuang HeZhao YangWei Bo