Ask about this productRelated genes to: PRDM13 antibody
- Gene:
- PRDM13 NIH gene
- Name:
- PR/SET domain 13
- Previous symbol:
- -
- Synonyms:
- PFM10
- Chromosome:
- 6q16.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2018-03-02
Related products to: PRDM13 antibody
Related articles to: PRDM13 antibody
- Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assay 284 mostly uncharacterized putative human TFs using selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq), revealing 74 new DNA binding motifs. To investigate whether TFs lacking detectable motifs preferably bind epigenetically modified DNA, we develop methylation-sensitive SMiLE-seq (meSMiLE-seq), a microfluidic assay that simultaneously probes binding to methylated and unmethylated DNA. Using meSMiLE-seq, we assay 114 TFs and identify DNA-binding models for 48 proteins, including known methylation-sensitive binding modes for POU5F1 and RFX5. 11 TFs prefer methylated DNA or display alternative methylation-dependent motifs (e.g. PRDM13), while 13 show aversion to methylated sequences (e.g. USF3). Finally, we identify ZHX2 as a putative Z-DNA binder. Altogether, our study significantly expands the human TF codebook, while providing a versatile platform to quantitatively assay the impact of DNA modifications on TF binding. - Source: PubMed
Publication date: 2026/08/05
Gralak Antoni JFaltejskova KaterinaYang Ally W HSteiner ClemenceRusseil JulieGrenningloh NadiaInukai SachiDemir MustafaDainese RiccardoOwen CooperPankevich Eugenia V Hughes Timothy RKulakovskiy Ivan VKribelbauer-Swietek Judith Fvan Mierlo GuidoDeplancke Bart - Thank you for sharing the comment [...]. - Source: PubMed
Publication date: 2026/05/29
Spedicati BeatricePasquetti DomiziaSantin AuroraZampieri StefaniaMorgan AnnaLenarduzzi StefaniaNardone Giuseppe GiovanniPaccagnella ElisaCappellani StefaniaDiplotti LauraPensiero StefanoParentin FulvioGasparini PaoloParodi Maurizio BattagliaGirotto Giorgia - We read the article by Spedicati et al [...]. - Source: PubMed
Publication date: 2026/05/29
Small Kent W - This study found that age-associated sleep changes are ameliorated by DR in the presence of Prdm13 signaling in the DMH, suggesting Prdm13+ DMH neurons will be of great interest to explore a potential intervention on age-associated sleep changes. - Source: PubMed
Publication date: 2026/05/28
Tsuji ShogoBrace Cynthia SYao RuiqingTanie YoshitakaTada HirobumiRensing NicholasMizuno SeiyaAlmunia JulioKong YingyiNakamura KazuhiroFurukawa TakahisaOgiso NoboruToyokuni ShinyaTakahashi SatoruWong MichaelImai Shin-IchiroSatoh Akiko - Multiple myeloma (MM) is a malignant plasma cell tumor. Mitochondria-related genes (MRGs) are significant inducers of ferroptosis. However, research on the involvement of mitochondria-ferroptosis-related genes (MFRGs) in the MM is relatively scarce, and further identification of key genes associated with MFRGs in MM treatment is needed. In this study, transcriptomic data and related genes were initially downloaded from public databases and literature. Subsequently, candidate genes were obtained by intersecting the differential expression genes (DEGs) from MM and control groups, and MFRGs. Through regression analyses, clinically relevant genomic signatures were delineated, culminating in the development of a predictive algorithm. An independent prognostic analysis was conducted, followed by the creation of a nomogram. Subsequently, these prognostic genes were studied from various aspects. Finally, the transcriptional abundance of predictive biomarkers was experimentally validated through reverse transcription quantitative polymerase chain reaction (RT-qPCR). The intersection of DEGs and MFRGs yielded 15 candidate genes. Then, GPR15, NLRP7, ZNF208, PRDM13, and CRIM1 were identified as prognostic genes. The prognostic model constructed using these prognostic genes was confirmed to be robust. The 2 independent prognostic factors (risk score and age) were determined, and the constructed nomogram provided an excellent predictive model. Then, risk score and activated dendritic cells were found to be significantly negatively correlated (cor = -0.43, p < 0.05). Additionally, GPR15 was positively associated with M2 macrophages (cor = 0.34, p < 0.05), while NLRP7 and PRDM13 were negatively associated with activated dendritic cells (cor = -0.34, p < 0.05; cor = -0.40, p < 0.05). There were 3 significantly different immune cells, 31 significantly immune checkpoint genes, and 11 significantly different immune checkpoints (p < 0.05). ZNF208, PRDM13, and CPIM1 were all mainly enriched in ribosome-related pathways. Finally, 86 potential drugs for the treatment of MM were discovered, such as shikonin. RT-qPCR results showed that NLRP7 and PRDM13 were significantly upregulated in MM group, while GPR15 and CRIM1 were significantly downregulated in MM group (p < 0.05). In this study, 5 MFRGs were identified as prognostic genes (GPR15, NLRP7, ZNF208, PRDM13, and CRIM1) for MM, which provide reference significance for the prognosis of MM. - Source: PubMed
Publication date: 2025/11/24
Wu JingLi ChenZhang JiayouSu JingXiao YutingJi Linhua