Ask about this productRelated genes to: ZNF71 antibody
- Gene:
- ZNF71 NIH gene
- Name:
- zinc finger protein 71
- Previous symbol:
- -
- Synonyms:
- Cos26, EZFIT
- Chromosome:
- 19q13.4
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-28
- Date modifiied:
- 2014-11-19
Related products to: ZNF71 antibody
Related articles to: ZNF71 antibody
- A recent study by Qin emphasized the potential of zinc finger protein 71 (ZNF71) as a promising biomarker for hepatocellular carcinoma (HCC). The authors offered valuable insights into the relationship between ZNF71 and various clinical and pathological stages of HCC. However, several limitations are required to be addressed to improve the findings. These limitations include concerns regarding patient selection, the generalizability of the results, and the necessity for functional validation to establish ZNF71's specific role in the progression of HCC. Furthermore, statistical issues related to multiple comparisons, confounding variables, and the inherent heterogeneity of high-throughput datasets warrant careful consideration. Future research should focus on multi-institutional cohorts, utilize models, and compare ZNF71 with established biomarkers to strengthen the clinical relevance of ZNF71. - Source: PubMed
Krishnan ArunkumarMukherjee Diptasree - Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive forms of liver cancer, with high morbidity and poor prognosis due to late diagnosis and limited treatment options. Despite advances in understanding its molecular mechanisms, effective biomarkers for early detection and targeted therapy remain scarce. Zinc finger protein 71 (ZNF71), a zinc-finger protein, has been implicated in various cancers, yet its role in HCC remains largely unexplored. This gap in knowledge underscores the need for further investigation into the ZNF71 of potential as a diagnostic or therapeutic target in HCC. - Source: PubMed
Qin KaiXiong Dan-DanQin ZhenLi Ming-JieLi QiHuang Zhi-GuangTang Yu-XingLi Jian-DiZhan Yan-TingHe Rong-QuanLuo JieWang Hai-QuanZhang Shu-QiChen GangWei Dan-MingDang Yi-Wu - Studies have revealed that inflammatory response is relevant to the tetralogy of Fallot (TOF). However, there are no studies to systematically explore the role of the inflammation-related genes (IRGs) in TOF. Therefore, based on bioinformatics, we explored the biomarkers related to inflammation in TOF, laying a theoretical foundation for its in-depth study. - Source: PubMed
Publication date: 2024/07/29
Du JunzheLiu HuaipuWang PengchengWu WenzhiZheng FengnanWang YuanxiangMeng Baoying - There are currently no effective biomarkers for prognosis and optimal treatment selection to improve non-small cell lung cancer (NSCLC) survival outcomes. This study further validated a seven-gene panel for diagnosis and prognosis of NSCLC using RNA sequencing and proteomic profiles of patient tumors. Within the seven-gene panel, expression combined with dendritic cell activities defined NSCLC patient subgroups ( = 966) with distinct survival outcomes ( = 0.04, Kaplan-Meier analysis). expression was significantly associated with the activities of natural killer cells ( = 0.014) and natural killer T cells ( = 0.003) in NSCLC patient tumors ( = 1016) using Chi-squared tests. Overexpression of ZNF71 resulted in decreased expression of multiple components of the intracellular intrinsic and innate immune systems, including dsRNA and dsDNA sensors. Multi-omics networks of and the intracellular intrinsic and innate immune systems were computed as relevant to NSCLC tumorigenesis, proliferation, and survival using patient clinical information and in-vitro CRISPR-Cas9/RNAi screening data. From these networks, pan-sensitive and pan-resistant genes to 21 NCCN-recommended drugs for treating NSCLC were selected. Based on the gene associations with patient survival and in-vitro CRISPR-Cas9, RNAi, and drug screening data, MEK1/2 inhibitors PD-198306 and U-0126, VEGFR inhibitor ZM-306416, and IGF-1R inhibitor PQ-401 were discovered as potential targeted therapy that may also induce an immune response for treating NSCLC. - Source: PubMed
Publication date: 2022/11/29
Ye QingHickey JustinSummers KathleenFalatovich BrianneGencheva MarietaEubank Timothy DIvanov Alexey VGuo Nancy Lan - The molecular mechanism of laryngeal squamous cell carcinoma (LSCC) is not completely clear, which leads to poor prognosis and treatment difficulties for LSCC patients. To date, no study has reported the exact expression level of zinc finger protein 71 (ZNF71) and its molecular mechanism in LSCC. - Source: PubMed
Publication date: 2022/11/11
Jiang Fang-ChengLuo Jia-YuanDang Yi-WuLu Hui-PingLi Dong-MingHuang Zhi-GuangTang Yu-LuFang Ye-YingTang Yu-XingSu Ya-SiDai Wen-BinPan Shang-LingFeng Zhen-BoChen GangHe Juan