Ask about this productRelated genes to: ZFP28 antibody
- Gene:
- ZFP28 NIH gene
- Name:
- ZFP28 zinc finger protein
- Previous symbol:
- -
- Synonyms:
- KIAA1431, mkr5
- Chromosome:
- 19q13.43
- Locus Type:
- gene with protein product
- Date approved:
- 2001-12-19
- Date modifiied:
- 2014-11-19
Related products to: ZFP28 antibody
Related articles to: ZFP28 antibody
- Fertilization involves fusion between sperm and metaphase II (MII) oocyte, initiating a cascade of events including oocyte activation, resumption of meiosis, formation and interdigitation of male and female pronuclei, and zygote formation. Total Fertilization Failure (TFF), characterized by the disruption of any of these processes, occurs in 1-3% of intracytoplasmic sperm injection (ICSI) cycles. The genetic basis of TFF remains largely unexplored. TFF can occur in cases where no single genetic cause is apparent, suggesting a potential polygenic contribution. - Source: PubMed
Publication date: 2025/11/04
Ata ManarChoucair FadiDjekidel Mohamed NadhirSousa Esteves MariaAl Ali FatimaNawaz ShoaibEl Taha LinaSoloviov OleksandrSathappan AbbiramiAliyev ElbayFakhro KhalidAwwad JohnnyAvella Matteo A - Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol and tobacco consumption. However, studies have demonstrated that human papillomavirus () infection, particularly , may also significantly influence disease progression. The KRAB-ZNF family of genes is involved in epigenetic suppression, and its involvement in carcinogenesis is the subject of extensive studies. The available literature data demonstrate that they may play different roles, both as tumor suppressors and oncogenes. In this study, six ZNF genes, , , , , , and , were tested using several in silico approaches based on the TCGA and GEO datasets. Our analyses indicate that the expression of the analyzed ZNFs was significantly downregulated in tumor tissues and depended on tumor localization. The expression levels of ZNFs differed between -positive vs. -negative patients depending on the clinical-pathological parameters. More specifically, the patients with higher levels of and showed better survival rates than those with a lower expression. In addition, the level of expression in -positive () patients was higher than in -negative () patients ( < 0.0001) and was associated with better overall survival (OS). In conclusion, we demonstrate that expression highly correlates with infection, which renders a potential biomarker for HNSCC prognosis and treatment. - Source: PubMed
Publication date: 2022/12/16
Sobocińska JoannaNowakowska JoannaMolenda SaraOlechnowicz AnnaGuglas KacperKozłowska-Masłoń JoannaKazimierczak UrszulaMachnik MartaOleksiewicz UrszulaTeresiak AnnaLamperska KatarzynaKolenda Tomasz - Organisms adapt their physiology and behavior to the 24-h day-night cycle to which they are exposed. On a cellular level, this is regulated by intrinsic transcriptional-translational feedback loops that are important for maintaining the circadian rhythm. These loops are organized by members of the core clock network, which further regulate transcription of downstream genes, resulting in their circadian expression. Despite progress in understanding circadian gene expression, only a few players involved in circadian transcriptional regulation, including transcription factors, epigenetic regulators, and long noncoding RNAs, are known. Aiming to discover such genes, we performed a high-coverage transcriptome analysis of a circadian time course in murine fibroblast cells. In combination with a newly developed algorithm, we identified many transcription factors, epigenetic regulators, and long intergenic noncoding RNAs that are cyclically expressed. In addition, a number of these genes also showed circadian expression in mouse tissues. Furthermore, the knockdown of one such factor, Zfp28, influenced the core clock network. Mathematical modeling was able to predict putative regulator-effector interactions between the identified circadian genes and may help for investigations into the gene regulatory networks underlying circadian rhythms. - Source: PubMed
Publication date: 2015/12/07
Schick SandraBecker KoljaThakurela SudhirFournier DavidHampel Mareike HildegardLegewie StefanTiwari Vijay K - - Source: PubMed
Publication date: 2009/03/28
Yajima IchiroKumasaka MayukoThang Nguyen DinhYanagishita TakeshiOhgami NobutakaKallenberg DavidNaito YujiYoshikawa ToshikazuSakashita NaomiKato Masashi - Transcription factors play an essential role in controlling gene expression during cardiac and vascular pathogeneses. Identification of regulatory genes in the cardiovascular system is a necessary step toward an understanding of the pathogenesis of congenital heart disease and acquired cardiovascular diseases. The Cys2/His2 type zinc finger genes are the single largest class of transcription factors in the human genome and many numbers of these krüpple-like zinc finger genes have been found to be involved in cardiac development or cardiovascular diseases. In this study, we have identified two novel human krüpple-like zinc finger genes named ZNF359 and ZFP28 from the human heart cDNA library. The complete human ZNF359 cDNA sequence is 3270bp and contains a 1932-bp open reading frame (ORF) that encodes a 643 amino acid protein with an N-terminal KRAB domain and 16 C-terminus zinc finger C2H2 motifs. The ZFP28 cDNA sequence is 4104bp and contains a 2076-bp ORF that encodes an 868 amino acid protein with an N-terminal signal peptide, two KRAB domains, and 14 C-terminal C2H2 zinc finger motifs. Northern blot analyses showed a strong expression of ZNF359 and ZFP28 in various tissues of adult human. A further analysis using human embryonic tissues (18-23 weeks) showed a development-specific expression pattern in heart, skeletal muscle, liver, lung, kidney, and brain, suggesting a role for these genes in embryonic development. - Source: PubMed
Zhou LiangZhu ChuanbingLuo KaimeiLi YongqingPi HualiangYuan WuzhouWang YuequnHuang ChunxiaLiu MingyaoWu Xiushan