Ask about this productRelated genes to: NOTCH1 antibody
- Gene:
- NOTCH1 NIH gene
- Name:
- notch receptor 1
- Previous symbol:
- TAN1
- Synonyms:
- -
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-13
- Date modifiied:
- 2019-04-23
Related products to: NOTCH1 antibody
Related articles to: NOTCH1 antibody
- Hepatocellular carcinoma (HCC) is characterized by profound metabolic reprogramming that promotes tumor progression. Although zinc finger MIZ-type containing 1 (ZMIZ1) has been implicated in several malignancies, its biological function and underlying mechanism in HCC remain unclear. - Source: PubMed
Publication date: 2026/08/18
He JiefengZhang ChaoChen GuoTang HaoMao ChunhuWu Gang - Diabetic foot ulcers (DFUs) represent a significant clinical challenge due to their high morbidity, infection risk, and poor healing rates. Emerging evidence highlights the therapeutic potential of Traditional Chinese Medicine in wound management. This study investigates the efficacy of Shengji Ointment (SJ)-a multi-herb formulation-in human subjects with DFUs and a diabetic rat model, specifically elucidating its modulation of the wound inflammatory microenvironment. - Source: PubMed
Publication date: 2026/09/03
Dai RuiGuo JingJing JinpengZhang YunShaLiu HongBinZhang ZhaohuiZhu Chaojun - Hypoxia-driven vascular, immune, and metabolic remodeling is a key biological process involved in cardiovascular diseases, cancer, and other complex systemic disorders. Acute mountain sickness (AMS) is an acute manifestation of hypobaric hypoxia, but its systemic molecular features remain incompletely defined. - Source: PubMed
Publication date: 2026/09/01
Ding WenjingYang YifanWei HuayingHu XinyuZhang HaopengAili AilifeilaChen XiaolanWang QiqiXue XinyingPan Lei - Protein O-glucosyltransferase (POGLUT1/Rumi) transfers an O-linked glucose (O-Glc) monosaccharide from UDP-Glc to a serine residue in epidermal growth factor-like (EGF) repeats with a specific consensus sequence. In mammals, GXYLT1 and GXYLT2 transfer xylose to this O-Glc monosaccharide. Previous studies showed that genetic deletion of Poglut1 in mice leads to embryonic lethality with defects in Crumbs2 (CRB2) trafficking and NOTCH1 signaling during development. Both CRB2 and Notch receptors have multiple EGF repeats with the O-Glc modification site. However, the roles of xylosyl elongation of O-Glc in protein trafficking and mammalian embryonic development are unknown. Here, we demonstrated that xylosyl elongation of O-Glc occurs in the ER and comprehensively analyzed O-Glc glycosylation on CRB2, NOTCH1, and NOTCH2 expressed in HEK293T cells by mass spectrometry. We found that most EGF repeats containing the consensus sequence were modified with O-Glc glycans, while the degree of xylosyl elongation varied among different EGF repeats, suggesting EGF repeat-specific regulation. GXYLT1 knockout cells showed reduced or lost xylosyl elongation, but GXYLT2 knockout cells did not. Cell-based assays demonstrated decreased secretion of substrate proteins in GXYLT1 knockout cells, which was rescued by wild-type GXYLT1. Analysis of Gxylt1 and Gxylt2 knockout mice revealed that Gxylt1 deletion, but not Gxylt2 deletion, caused embryonic lethality. Altogether, our data suggest that GXYLT1 plays a major role in xylosyl elongation of O-Glc glycans and thereby contributes to the ER quality control and trafficking of CRB2, NOTCH1, and NOTCH2 in HEK293T cells while GXYLT1 and GXYLT2 have distinct biological functions during mouse embryonic development. - Source: PubMed
Publication date: 2026/09/15
Mita YukihiroCho SoominTsukamoto YoheiSaiki WataruOkamura MioFujita YukiNiknejad NimaFunada DaichiSuzuki FugaOhkawa KensukeJo TaikiUrata YusukeKurebayashi YuukiMinami AkiraTakahashi TadanobuHibi HideharuOkajima TetsuyaJafar-Nejad HamedTakeuchi Hideyuki - T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) is an aggressive neoplasm of immature T-lymphoid precursors that is classified as T-cell acute lymphoblastic leukemia when the primary site of involvement is the bone marrow and peripheral blood and as T-cell lymphoblastic lymphoma when it presents as a solid mass, most commonly in the anterior mediastinum. The neoplastic cells are defined by expression of T-lineage antigens (cytoplasmic or surface CD3) together with one or more markers of immaturity (terminal deoxynucleotidyl transferase, CD1a, CD34, CD99, or CD117) and must not fulfill criteria for early T-cell precursor acute lymphoblastic leukemia (ALL). This entity shows a marked male predominance (male:female ≈ 2:1) and predominantly affects children, adolescents, and young adults, accounting for approximately 15% of childhood ALL and 20%-25% of adult ALL cases. Pathologic diagnosis increasingly relies on recurrent molecular alterations such as activating NOTCH1 mutations (>60% of cases), transcription factor rearrangements, and cell-cycle regulator inactivation. Although intensive multiagent chemotherapy regimens have substantially improved outcomes, particularly in pediatric patients, adults and high-risk molecular subgroups continue to experience inferior survival. This review provides a practical, pathology-oriented update on the epidemiology, pathogenesis, diagnostic criteria, differential diagnosis, prognostic factors, and current treatment approaches for T-ALL/LBL. - Source: PubMed
Publication date: 2026/09/15
Danielson DavidLagerstrom Ian TRogers MaxSimon KyleAguilera Nadine SAuerbach Aaron