Ask about this productRelated genes to: Pura antibody
- Gene:
- PURA NIH gene
- Name:
- purine rich element binding protein A
- Previous symbol:
- -
- Synonyms:
- PURALPHA, PUR1, PUR-ALPHA
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-19
- Date modifiied:
- 2017-09-22
Related products to: Pura antibody
Related articles to: Pura antibody
- Internal medicine specialists have always been one of the pillars that support the health of Indonesian people. Currently, there is no available survey regarding the socio-demography, lifestyle, and income of any medical specialist in Indonesia. This study aims to report this gap in knowledge amongst internists across Indonesia. - Source: PubMed
Sukrisman LugyantiYunihastuti EvyNasution Sally AmanGinanjar EkaSalim SimonRachman AndhikaPitoyo Ceva WicaksonoHidayat RudySusilo AdityoNufus HayatunSusanto HermawanDarmadi DarmadiPurnomo Hery DjagatAman Andi MakbulHartopo Anggoro BudiSelfie SelfieRitonga ErvitaMahadita Gede WiraPartan Radiyati UmiAbubakar AzzakiSamsu NurPutranto WachidAlexander ReinaldoRosdiana DaniHendratta CeciliaHanif Akmal MufriadyIndrasari AstriedWinulyo Erwanto BudiPura LukmanDjallalluddin DjallalluddinSatriya GiriPanjaitan Andi M HElfiani ElfianiGunawan BudimanNachrowi Annisa PuspitasariGirsang Kurniakin W SPangkahila Erwin AAnggoro JokoNurbayati DayangDarkuthni Fahmi RIrianto PetrusKomariatun KomariatunKurniati AnnelinAswar HaerilMokoginta Nelyan HPawa Leily DAmbar EdwinRiswan RiswanPratama SamuelAdli ImamRahmani Nurul InayahAfifah Amalia ZahraFajar Muhammad IlhamHerliana MonikaAnwar Zahra NurilSiswanto Mariska Andrea - Cerebral malaria (CM) is associated with disruption of the blood-brain barrier (BBB), neurovascular injury, and high mortality. Although mesenchymal stem cells (MSCs) have demonstrated therapeutic efficacy in experimental cerebral malaria (ECM), the molecular mechanisms underlying these effects remain insufficiently defined. In this study, we investigated how MSC treatment modulates host miRNA networks during ECM using a Plasmodium berghei ANKA infection in C57BL/6 mice. MSC treatment significantly reduced clinical severity, improved survival, and preserved BBB integrity, as indicated by decreased Evans blue extravasation and reduced microvascular sequestration within brain. RNA sequencing identified 64 differentially expressed miRNAs associated with MSC treatment. Pathway enrichment using DIANA-miRPath v4.0 identified 23 miRNAs associated to CM-relevant pathways. Eleven miRNAs with highest pathway interactions were subsequently validated by RT-qPCR, confirming consistent down-regulation of eight miRNAs following MSC treatment. miRNA-mRNA network construction revealed several hub genes, including Rora, Nfia, Nfib, Slc1a2, Tcf4, Pura, and Atxn1, linked to neurological phenotypes relevant to CM pathology. Collectively, these findings suggest that MSCs mitigate ECM pathology by reprogramming miRNA-mRNA regulatory networks governing cerebral and neuronal stability. The identified miRNA-mRNA hubs represent promising candidates for future biomarker studies and may provide a foundation for the development of adjunctive therapeutic strategies against cerebral malaria. - Source: PubMed
Publication date: 2026/07/07
Chaudhary AmrendraSharma InduThakur Reva SharanRanjha RiteshDas Jyoti - The mammary gland has a remarkable ability to renew and repair itself, making mammary epithelial stem cells (MESCs) critical targets for understanding lactation biology and developing therapeutic interventions for intramammary infections. - Source: PubMed
Sharma NeeleshDevi SapnaKour SandeepPagoch Sandeep SinghNatesan BalajiKour ShaguneetPratama Dyah Ayu Oktavianie ArdhianaLee Sung-Jin - Dengue virus serotype-3 (DENV-3) infection remains a clinical problem for which no specific antiviral agent has yet been identified. The rhizome of (red galangal) is rich in natural glycosides with antioxidant and anti-inflammatory properties. However, studies related to antidengue from using and methods have not been widely conducted. - Source: PubMed
Publication date: 2026/05/31
Herdiansyah Mochammad AqilahDarmanto WinWinarni DwiRohmatika Aulia UmiPutri Rr Aulia Rahmawati KusumaSusilo Raden Joko KuncoroningratSucipto Teguh HariWiradana Putu AnggaKhanifah FarachErnawati Ernawati - Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia, dyslipidemia, and oxidative stress, leading to severe systemic complications. Medicinal plants rich in polyphenolic compounds have gained increasing attention as complementary therapeutic agents. This study aimed to comparatively evaluate the chemical composition, as well as the antidiabetic, hypolipidemic, and antioxidant effects of and in a streptozotocin-induced diabetic model. Although has been more extensively investigated for its antidiabetic potential, the pharmacological relevance of in diabetes remains insufficiently characterized, particularly in direct comparison with a recognized phytotherapeutic comparator. Hydroalcoholic tinctures prepared from L. herb and L. leaves were subjected to phytochemical analysis using High-Performance Thin-Layer Chromatography (HPTLC) for the identification of flavonoids and phenolcarboxylic acids, alongside spectrophotometric determination of total polyphenol and flavonoid content. Experimental diabetes was induced in CD1 mice by streptozotocin administration. Animals were treated orally for 35 days, and glycemic parameters, lipid profile, body weight, food and water intake, and oxidative stress markers (MDA, SOD, TAC, and GPx) were evaluated. HPTLC/CSS screening indicated the presence of rutin, chlorogenic acid, and caffeic acid in , while showed stronger densitometric signals for phenolcarboxylic acid-type compounds, particularly chlorogenic and caffeic acids. Total polyphenol and flavonoid content were also higher in (433.89 ± 8.67 mg/L GAE; 154.38 ± 3.08 mg/L QE) compared to (269.28 ± 5.25 mg/L GAE; 132.75 ± 2.65 mg/L QE). Functionally, demonstrated a significant antihyperglycemic effect from day 14 ( = 0.009) and improved lipid parameters, while showed a delayed glycemic effect, significant only at day 35 ( = 0.014), without significant hypolipidemic activity. In contrast, exerted a marked antioxidant effect, significantly increasing GPx activity ( = 0.025) and reducing MDA levels ( = 0.053). showed stronger antihyperglycemic and hypolipidemic effects, while was mainly associated with antioxidant-related biochemical changes. These differences may be influenced by phytochemical composition, but they cannot be attributed solely to total polyphenol or flavonoid content. - Source: PubMed
Publication date: 2026/06/13
Roxana KosticiVasilica Pirscoveanu Denisa FlorianaTrasca Diana-MariaKamal Adina MariaVladulescu CarmenVarut Renata MariaDorin Pluta IonCîrțînă DanielaStoica MariaPopa RomeoPura Gabriela