Ask about this productRelated genes to: Pura antibody
- Gene:
- PURA NIH gene
- Name:
- purine rich element binding protein A
- Previous symbol:
- -
- Synonyms:
- PURALPHA, PUR1, PUR-ALPHA
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-19
- Date modifiied:
- 2017-09-22
Related products to: Pura antibody
Related articles to: Pura antibody
- Benign paroxysmal positional vertigo (BPPV) involving multiple semicircular canals (MC-BPPV) is an uncommon variant in which otoconia dislodged from the utricular macula migrate into two or more canals, provoking brief vertigo episodes with positional changes. The single-canal variant predominates, most often affecting the posterior canal, followed by the horizontal and anterior canals. MC-BPPV typically presents with ipsilateral or contralateral posterior-horizontal canal combinations, while atypical posterior canal variants are rarer and require careful nystagmus evaluation during positional testing. - Source: PubMed
Vats ShreyaVats Ajay KumarKothari Sudhir - Baroque horses represent a distinctive group of breeds that emerged mainly between the 16th and 18th centuries, shaped by the demands of European royalty and their courts. Although recognised as separate breeds, they share common ancestry, breeding goals, and historical gene flow. This study aimed to evaluate their genomic diversity, population structure, and admixture patterns. We analysed 1 160 individuals from eight breeds - Lipizzan, Old Kladruby Horse, Pura Raza Española, Lusitano, Friesian, Criollo, Peruvian Paso, and Puerto Rican Paso Fino - using 34 026 single-nucleotide polymorphisms, with the Croatian Arab horse included as an outgroup. The Lipizzan was further divided into national subpopulations, the two Old Kladruby subpopulations defined by colour (black and grey), and within the Pura Raza Española, the Carthusian strain was treated as a distinct subpopulation. Observed genetic diversity, measured by heterozygosity and haplotype richness, was broadly comparable across breeds, although clear differences were observed between breeds with the lowest values (Friesian) and those with the highest values (Lusitano and Criollo). Genomic inbreeding coefficients, estimated using runs of homozygosity (F) and homozygosity-by-descent segments (F), ranged from ∼0.06 to ∼0.29 and ∼0.14 to ∼0.27, respectively. These values indicate relatively high levels of inbreeding, which may reflect the closed breeding structure of the populations and their relatively limited effective population sizes. In contrast, most individual inbreeding coefficient (F) values were negative, reflecting deliberate avoidance of close-relative matings. Estimates of contemporary effective population size (N) ranged from ∼50 to ∼240 across breeds, depending on the method. Historical N trajectories revealed two distinct demographic decline patterns: one occurring around 12 generations ago and the other around 22 generations ago. Evidence of recent between-breed gene flow was detected among Iberian breeds and between Croatian Arab and Lusitano, whereas shared historical ancestry among Baroque breeds was evident across populations. These results provide new insights into the genomic architecture of Baroque horses and offer valuable guidance for managing their genetic diversity. - Source: PubMed
Publication date: 2026/07/07
Vostra-Vydrova HMoravcikova NKasarda RShihabi MDruet THalvonik AHofmanova BDovc PZorc MMolina ADemyda-Peyrás SValera MKovács MPosta JRogić BCubric-Curik VVostry LCurik I - : Diabetes mellitus is a multifactorial metabolic disorder characterized by chronic hyperglycemia, oxidative stress, and lipid metabolism dysregulation, leading to severe systemic complications. Increasing interest has been directed toward plant-derived bioactive compounds as potential therapeutic alternatives. The present study aimed to comparatively evaluate the phytochemical profile and biological effects of and in a streptozotocin-induced experimental model of diabetes mellitus. : Aqueous extracts of both plant species were prepared and characterized using high-performance liquid chromatography and spectrophotometric assays to determine phenolic and flavonoid content. Antioxidant activity was assessed using the DPPH radical scavenging method. In vivo experiments were conducted on streptozotocin-induced diabetic mice over a five-week period, evaluating glycemic levels, lipid profile, body weight, food and water intake, and oxidative stress markers, including SOD, GPx, GR, and lipid peroxidation. : Both extracts exhibited antioxidant activity and contained measurable amounts of phenolic compounds and flavonoids. demonstrated higher radical scavenging capacity, whereas showed higher total flavonoid content. In vivo, administration of the plant extracts was associated with improvements in selected metabolic parameters compared with untreated diabetic animals. In particular, produced a marked reduction in blood glucose levels and improved lipid profile and oxidative stress markers under the present experimental conditions. Both extracts reduced hyperglycemia, hyperlipidemia, and oxidative stress markers compared with the diabetic control group. : The findings provide preliminary evidence that aqueous extracts of and may exert glucose-lowering and antioxidant effects in a streptozotocin-induced experimental model of diabetes. Under the present experimental conditions, administration of was associated with greater improvement in selected metabolic and oxidative stress parameters than the botanical comparator . However, these findings remain preliminary and require confirmation in dose-response studies including a standard pharmacological control. However, these results should be interpreted cautiously because the study was conducted in a short-term animal model and did not include a positive pharmacological control or direct mechanistic validation. Further studies including standard antidiabetic drugs, insulin measurements, extended biochemical and histological evaluation, and mechanistic assays are required before any therapeutic relevance for diabetes management can be established. - Source: PubMed
Publication date: 2026/07/15
Pirscoveanu Denisa Floriana VasilicaArsenie Cristian CosminTrasca Diana-MariaKamal AdinaPopescu CristinaVladulescu CarmenPluta Ion DorinVarut Renata MariaDirnu RodicaStoica MariaCîrțînă DanielaPura Gabriela - γ-Cyclodextrin (γ-CD) is a cyclic oligosaccharide with high aqueous solubility, low toxicity, and a large internal cavity that enables inclusion complex formation with selected bioactive compounds. Beyond its established role as a pharmaceutical and food excipient, emerging evidence suggests that γ-CD may influence metabolic regulation through interactions with the gut microbiota, microbial fermentation products, and host metabolic signaling pathways. This review synthesizes current evidence on the effects of γ-CD on short-chain fatty acid production, lipid homeostasis, glycemic control, and obesity- and type 2 diabetes-related metabolic disturbances. Particular attention is given to the gut-metabolism axis, SCFA-mediated GPCR signaling, microbial taxa potentially involved in γ-CD fermentation, and the relative contribution of prebiotic-like effects versus lipid-binding mechanisms. Available data indicate that γ-CD may modulate microbial composition and metabolic outcomes, but most evidence derives from in vitro experiments, animal models, and limited human studies. Therefore, the clinical relevance of γ-CD remains insufficiently established. Future studies should include well-designed human trials, standardized doses, multi-omics analyses, and direct comparisons between native and modified cyclodextrins to clarify whether γ-CD can be translated into nutritional or therapeutic strategies for metabolic disorders. - Source: PubMed
Publication date: 2026/07/09
Vasilica Pirscoveanu Denisa FlorianaDorin Pluta IonRodica DîrnuVladulescu CarmenTrasca Diana-MariaVarut Renata MariaKamal AdinaStoica MariaPura GabrielaPopa RomeoRadulescu VirginiaStoica George Alin - Postbiotics are defined as preparations of inanimate microorganisms and/or their components that confer a health benefit on the host. Although interest in postbiotics has increased substantially, their translational use in functional foods remains insufficiently characterized with respect to preparation identity, production methodology, food-matrix compatibility, mechanistic specificity, and regulatory positioning. This PRISMA-guided structured review aims to synthesize current evidence on postbiotics in functional food and nutraceutical contexts, with particular emphasis on preparation-based characterization, gut-brain axis-related mechanisms and clinical findings, food matrix applicability, and regulatory and health-claim considerations. Unlike broader postbiotic reviews that mainly address definitions, general health effects, or technological stability, this review integrates preparation identity, production process, gut-brain axis-related evidence, food matrix compatibility, and regulatory/health-claim translation within a single functional food framework. A structured literature search was conducted in Scopus and Web of Science Core Collection and was completed on 16 February 2026. The search strategy included three conceptual blocks: postbiotic and inactivation-based preparation terms, functional food/nutraceutical and food matrix terms, and gut-brain axis-related clinical and mechanistic terms. Cosmetic, topical, veterinary, animal feed, and aquaculture-focused publications were excluded. The export files contained 131 records from Scopus and 136 from the Web of Science Core Collection, yielding 267 records after applying document-type and language filters. After manually removing duplicates, 237 unique records were screened. Following title/abstract screening, 176 records were excluded as outside the scope of the review, and 61 publications were retained for full-text assessment and final thematic synthesis. The review was reported according to applicable PRISMA 2020 items. The evidence was organized into three thematic domains: gut-brain axis-related clinical findings, mechanistic evidence, and food matrix/product development applications. Heat-inactivated preparations, including CP2305 and SNK12, have shown preliminary effects on stress-related symptoms, sleep quality, and selected neuroendocrine or inflammatory biomarkers in human studies. Mechanistic pathways include gut barrier integrity, immunomodulation, short-chain fatty acid signaling, tryptophan-kynurenine-serotonin metabolism, vagal communication, and regulation of the hypothalamic-pituitary-adrenal axis. Food matrix studies support the potential application of postbiotics in fermented dairy products, cereal-based systems, plant-based matrices, powders, concentrates, and bioactive packaging; however, matrix-dependent effects on bioavailability, sensory quality, and biological activity remain incompletely defined. Postbiotics provide a stable translational platform for functional-food development, but their scientific and commercial use requires clear characterization of the microbial source, production process, inactivation method, retained active fractions, dose metric, delivery matrix, and clinically meaningful endpoint. Future studies should avoid broad category-level claims and prioritize preparation- and matrix-defined human evidence with standardized safety reporting. - Source: PubMed
Publication date: 2026/07/10
Elmas SelinCîrțînă DanielaDîrnu RodicaPlută Ion DorinVarut Renata MariaVladulescu CarmenKamal Adina MariaPura GabrielaPopa RomeoSakizlian Denisa DanielaȚîștea-Marcoci Oana Diana