Ask about this productRelated genes to: Rest antibody
- Gene:
- REST NIH gene
- Name:
- RE1 silencing transcription factor
- Previous symbol:
- DFNA27
- Synonyms:
- NRSF, XBR
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-12
- Date modifiied:
- 2018-07-30
Related products to: Rest antibody
Related articles to: Rest antibody
- Adults with schizophrenia exhibit substantial and widespread cognitive impairment, with subtle cognitive deficits already apparent in childhood and adolescence - many years prior to the onset of psychosis. Here, we focus on evidence from population-based research highlighting findings specific to cognitive impairment (as indexed by IQ) that precedes the onset of schizophrenia. We illustrate that (i) cognitive impairment worsens from early childhood onwards through to the onset of psychosis; (ii) this early and progressive cognitive impairment is rarely present in other psychotic disorders. At the same time, (iii) early cognitive impairment is not universal in schizophrenia; and (iv) a substantial role for genes affecting both schizophrenia and early life cognitive impairment has not been unequivocally proven. We suggest that a subgroup of patients with schizophrenia is characterized by progressive premorbid cognitive impairment. This group is developmentally distinguishable from the rest of patients with psychoses. Future studies should focus on understanding the (possibly unique) etiology in this neurodevelopmental subgroup of schizophrenia patients. - Source: PubMed
Publication date: 2026/04/28
Reichenberg AbrahamKahn René S - Despite efforts to improve playground safety, injuries persist. Parents and carers (caregivers) have a responsibility for ensuring the safety of their children while fostering opportunities for growth and development. Ensuring caregivers choose safe and age-appropriate playgrounds helps to reduce the likelihood of injuries and ensures an enjoyable experience. This study sought to use a publicly available checklist to review the safety of playgrounds to assist caregivers in making informed decisions around how safe a playground is for their children. - Source: PubMed
Publication date: 2026/04/28
Myles LouiseEagers JackieTurner DeniseSmith MoiraMcGuckin TenealeSalata KarenJones TamraFranklin Richard Charles - Cold carbonated water is a simple, inexpensive preparation that could plausibly reduce gastric uptake through a combination of gastric distension, altered motility from CO, and reduced mucosal perfusion from cooling. To our knowledge, this approach has not been investigated in the setting of Rb PET myocardial perfusion imaging. We conducted a same-day, within-subject study of 20 patients undergoing surveillance for cancer therapy-related cardiac dysfunction and included 20 additional patients from the same cohort who did not receive the intervention. Each patient underwent 2 rest Rb PET scans; between scans, each drank up to 500 mL of cold carbonated water. Gastric spillover was assessed in 3 ways: subjective comparison (better/worse/unchanged), a 4-level semiquantitative interference severity score, and quantitative myocardial-to-extracardiac (MYO/EXT) ratios using voxel- and contour-based region-of-interest methods. Severity scores shifted lower after the intervention ( = 0.003). The scores for 11 of 20 patients improved, 9 were unchanged, and none worsened. MYO/EXT uptake ratios increased with both region-of-interest methods (voxel: from 1.67 ± 0.61 to 1.98 ± 0.50, = 0.041; contour: from 1.60 ± 0.34 to 1.82 ± 0.37, = 0.006). Readers judged improvement in 75% and 80% of cases, respectively, with 75% concordance. In contrast, the nonintervention group showed no significant differences in semiquantitative scores or MYO/EXT uptake ratios between scans. Cold carbonated water reduced gastric interference during rest Rb PET myocardial perfusion imaging across visual and quantitative metrics. The intervention is simple and well tolerated. Larger, controlled studies, especially during stress imaging, are warranted. - Source: PubMed
Publication date: 2026/04/28
Nielsen Marc ØstergaardTietgen NinaJensen Lars Thorbjørn - Cyclothone (bristlemouths) is considered the most numerically abundant genus of fish in the world and primarily inhabits the mesopelagic and bathypelagic ocean zones. Cyclothone body fossils date to the middle Miocene (approximately 11-16 million years ago (Ma)), indicating a relatively recent evolution of the group, likely linked to global cooling and the expansion of modern, oxygen-poor mesopelagic habitats. However, deep-sea fishes are rarely preserved in the fossil record, leading to imprecise timing of their evolutionary origins. Ichthyoliths, microfossil fish teeth preserved in oceanic sediments, provide a detailed fossil record of deep-sea fishes and allow for precise dating of fossil occurrences, but identifying these isolated teeth to specific taxonomic lineages is challenging. Here, we demonstrate that spiral striations are found on the teeth of extant Cyclothone species but are absent on other taxa in the Order Stomiiformes or within the rest of the fish tree of life, linking this distinct micromorphology to Cyclothone. We found numerous microfossil fish teeth with these distinctive spiral striations from the Southern Ocean, dating back to 55.6 Ma, at International Ocean Discovery Program Site U1553, pushing the earliest known fossil occurrence of Cyclothone to the extreme greenhouse conditions of the Earliest Eocene. - Source: PubMed
Tennenbaum KarinneCohen Karly EBissell Immanuel ChasSibert Elizabeth C - Recent investigations into exercise-induced tumor suppression suggest that higher exercise frequency enhances tumor control when the total duration of exercise within a specified time window is not constrained. An equally compelling avenue for exploration is the effect of increased exercise frequency under the condition of a fixed total exercise duration within the same time frame. Using a mathematical model of IL-6-mediated interactions between natural killer (NK) cells and tumor cells, here we explore how different combinations of exercise and rest intervals -while maintaining a constant overall exercise volume -affect tumor suppression. Our results reveal a nonmonotonic tumor response and key metrics such as the time of maximum tumor suppression and the duration of tumor suppression are found to decrease with increasing exercise frequency. Interestingly, unlike earlier study where increasing exercise frequency leads to increase in tumor suppression, here we find that under fixed exercise volume constraints, increased frequency diminishes therapeutic efficacy of exercise, suggesting exercise bouts with longer duration are more effective in suppressing tumors. These findings highlight the importance of considering total exercise volume when designing exercise-based cancer interventions. - Source: PubMed
Publication date: 2026/04/28
Dorchhuon Mary LBagarti TrilochanKumar Niraj