Ask about this productRelated genes to: FGD1 antibody
- Gene:
- FGD1 NIH gene
- Name:
- FYVE, RhoGEF and PH domain containing 1
- Previous symbol:
- FGDY
- Synonyms:
- ZFYVE3
- Chromosome:
- Xp11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: FGD1 antibody
Related articles to: FGD1 antibody
- Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized by isolated cortisol deficiency and elevated adrenocorticotropic hormone (ACTH) levels. Variants in , which encodes mitochondrial thioredoxin reductase 2, have recently been implicated in FGD; however, the phenotypic and mutational spectrum remain extremely limited. - Source: PubMed
Publication date: 2026/05/28
Al Alwan IbrahimAlhamoudi Kheloud MAlzaben Abdullah IbrahimAlmulhem BeshaierQawasmi NawalAlswailem MeshaelAlotaibi SaraAlsaihati BurairJabaan AmjadMahzari MoeberFlück Christa EAlzahrani Ali S - Asthma is a chronic respiratory disease affecting over 230 million people worldwide, with higher prevalence in women. Environmental allergens such as house dust mite (HDM) trigger airway inflammation and hyperresponsiveness (AHR), yet the epigenetic mechanisms underlying these responses remain poorly understood. Furthermore, the role of estrogen receptors in the context of asthma is understudied. We aimed to investigate whether estrogen receptor-specific DNA methylation contributes to HDM-induced airway remodeling and hyperresponsiveness. Male and female C57BL/6J wild-type mice and estrogen receptor α and β knockout mice (Esr1 and Esr2) were exposed to HDM or phosphate-buffered saline for five weeks. DNA methylation and RNA sequencing data were obtained from snap-frozen whole lung tissues. HDM exposure resulted in widespread differential methylation of genes associated with inflammation and AHR, including . Notably, the absence of estrogen receptor β (in Esr2 mice) produced the most pronounced methylation patterns, particularly in females. Pathway enrichment analysis revealed asthma-relevant processes such as extracellular matrix remodeling, leukocyte adhesion and migration, airway smooth muscle contraction, and inflammatory signaling. Integration of methylation and gene expression data confirmed significant correlations (p<0.05) for , , and , and a marginal correlation for Chst7 (p<0.1), implicating these genes in allergic asthma pathogenesis. Our findings demonstrate that HDM exposure induces sex-specific epigenetic changes mediated by estrogen receptor status, highlighting a potential mechanism for increased asthma susceptibility in women. These results can inform estrogen receptor-targeted treatment strategies for allergic airway diseases. - Source: PubMed
Publication date: 2026/06/12
Commodore SarahEkpruke Carolyn DamilolaAlford RachelBorges-Sosa Omar AlejandroRousselle DustinBabayev MaksatIgwe ChukwudikeHemmerich Christopher MRusch Douglas BSilveyra Patricia - Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug-resistant tuberculosis (MDR-TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug-susceptible and drug-resistant () strains. However, data on its resistance mechanisms, drug susceptibility testing (DST), clinical effectiveness, safety, and pharmacokinetics remain limited. This review aims to summarize the most recent molecular, structural, and clinical evidence related to DLM. - Source: PubMed
Publication date: 2026/05/04
Islam Md MahmudulHasan Md ZahidTusar Md Touki TahamidHossain Md YeaminHossain Md MotaherJubayed Md Abdulla AlJubaer-Al-Abedin MdSoikot SheikhAkther ShanzidaBhuyian JahidGazi Hafizur RahmanHasan B M MahmudulAzam Md ShofiulHaque Md EnamulAbdullah-Al-Jubayer Hasan Md FarukHaydar F M AliKhalekuzzaman MdIslam Md TorequlHasan Sohel - MDR TB treatment is now facing the perils of emerging resistance to BDQ(bedaquiline) and DLM(delaminid). Both DLM and PRT(pretomanid) belong to the nitroimidazole group of drugs. Drug resistance in Mycobacterium Tuberculosis (MTB) is an ever changing, continuous and evolving process whereby the bacteria finds new genetic mutations to escape destruction by the newer drugs. DLM and PRT belong to the same class of drugs and resistance to both drugs have been described with mutations in five M. tuberculosis genes (ddn, fgd1, fbiA, fbiB, and fbiC) resulting in very high level of cross-resistance between the two drugs. Mutations in Rv2983 (fbiD), fbiB genes and some ddn allelles (S78Y, Y133C) can cause resistance to PRT but the strains may retain susceptibility to DLM. These reasons may lead to slight preference for DLM as compared to PRT. Such implications may be also kept in mind while treatment of MDR-TB with DLM and PRT. - Source: PubMed
Publication date: 2025/09/20
Sharma AmitChatterjee PoulomiShastry Shashank - BACKGROUND: Cervical cancer remains a significant public health concern, particularly in rural communities where access to screening and diagnostic services is limited. Despite being preventable through HPV vaccination and early detection via screening, cervical cancer continues to pose substantial health challenges in resource-limited settings. Colposcopy, a crucial diagnostic procedure for women with abnormal screening results, faces various implementation challenges in rural healthcare settings. OBJECTIVE: This study explores healthcare professionals' perceptions, experiences, and identified barriers affecting cervical cancer screening services uptake among women in rural communities, with particular focus on colposcopy service delivery challenges and potential improvement strategies. METHODS: Two qualitative focus group discussions were conducted with healthcare professionals (n = 18 total; FGD1: n = 9, FGD2: n = 9) involved in cervical cancer screening services in rural areas. Participants included obstetrician-gynaecologists, general practitioners, and healthcare providers with experience in colposcopy services. Data were analysed using thematic analysis to identify key themes and patterns. RESULTS: Healthcare professionals identified multiple interconnected barriers affecting cervical cancer screening services uptake, including: (1) limited awareness and cultural beliefs among rural women, (2) infrastructural challenges including equipment shortages and power supply issues, (3) workforce limitations and inadequate training, (4) accessibility and transportation barriers, and (5) security concerns in rural areas. Despite these challenges, professionals acknowledged the critical importance of colposcopy in early cervical cancer detection and prevention. CONCLUSIONS: Based on healthcare professionals' experiences in this study of three local government areas in Rivers State, successful implementation of cervical cancer screening services in rural communities requires a multi-faceted approach addressing infrastructure development, continuous professional training, community education programmes, and policy support. Healthcare professionals emphasise the need for sustained commitment from government and non-governmental organisations to bridge existing gaps in cervical cancer prevention services. - Source: PubMed
Publication date: 2026/04/06
Amadi AzubuikeLawal MuiliKhan HafizJaphet Sharry