Ask about this productRelated genes to: HLTF antibody
- Gene:
- HLTF NIH gene
- Name:
- helicase like transcription factor
- Previous symbol:
- SNF2L3, SMARCA3
- Synonyms:
- HIP116A, HLTF1, RNF80
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-08
- Date modifiied:
- 2016-10-05
Related products to: HLTF antibody
Related articles to: HLTF antibody
- Hepatitis B virus (HBV) e antigen (HBeAg) plays a critical role in inducing macrophage activation and subsequent immune tolerance, which facilitates viral immune escape. However, the underlying spatial 3D genomic and epigenetic mechanisms driving this macrophage dysfunction remain largely unknown. - Source: PubMed
Publication date: 2026/07/16
Liu TiantianXie XiaoyuMa ShujunCao HuilingWang WenwenYu ZhenFeng YueminQi JianniBian Hongjun - - Source: PubMed
- The SNF2-family Helicase-Like Transcription Factor (HLTF) has been implicated in tumorigenesis, with evidence suggesting both tumour-suppressive and oncogenic functions. To clarify the nature of this increasingly emerging double function, we analysed the full HLTF's alterome across TCGA cohorts combining first gene expression with genomic and epigenomic layers of de-regulation, and investigating further their determinants through the integration of DNA methylation profiles - both at promoter-proximal and distal regions, the copy-number alterations, and all somatic mutations. This multi-layered analysis highlighted specific context-dependent HLTF's regulatory configurations across human cancers, even modulated by either dosage effects or loss-of-function events. The clinical relevance of HLTF's alterations, identified through tumour-specific associations with patient outcomes, supports its potential as new biomarker in cancer overall. - Source: PubMed
Publication date: 2026/07/24
Canevotti AlessiaTursunović MarijaTigani WendalinaPesole GrazianoChiara MatteoDe March Matteo - Bladder cancer remains highly prone to cisplatin resistance, which markedly limits therapeutic efficacy and contributes to poor clinical outcomes. Although dysregulation of E3 ubiquitin ligases has been implicated in tumor progression and drug resistance, the specific ligases that drive cisplatin resistance in bladder cancer and their underlying mechanisms remain incompletely defined. In this study, integrated analysis of public transcriptomic datasets identified RBCK1 as an aberrantly upregulated E3 ubiquitin ligase associated with malignant progression and cisplatin resistance in bladder cancer. Functional assays showed that RBCK1 promoted clonogenic survival and reduced cisplatin sensitivity in bladder cancer cells. Mechanistically, RBCK1 directly interacted with the helicase-like transcription factor HLTF and facilitated its ubiquitin-proteasome-dependent degradation, thereby decreasing HLTF protein stability. Loss of HLTF relieved suppression of the JAK2/STAT3 pathway and enhanced STAT3 activation. Rescue experiments further demonstrated that HLTF depletion attenuated the cisplatin-sensitizing effect induced by RBCK1 knockdown, whereas pharmacological inhibition of STAT3 with Stattic abrogated this resistance-restoring phenotype. Collectively, these findings identify an RBCK1-HLTF-JAK2/STAT3 regulatory axis that promotes cisplatin resistance in bladder cancer cells, and xenograft validation further supports the role of RBCK1 depletion in enhancing cisplatin response in vivo. Further clinical studies are warranted to determine the translational relevance of targeting this pathway in cisplatin-treated bladder cancer. - Source: PubMed
Publication date: 2026/07/16
Yang XinDing ZexianPengwang YaWei YongbaoBin Yan Xiong WeiFeng YeqianGao YunliangCheng Hongtao - Heart failure (HF) is the terminal stage of cardiovascular disease with high global prevalence and poor prognosis. This study aimed to identify lactylation-related genes as novel diagnostic biomarkers for HF using bioinformatics and machine learning approaches. - Source: PubMed
Publication date: 2026/07/16
Zhang YanLuo HaixiaJia XiaojieFeng RenqianWang KexinZhao RanQi BingchaoLi Yan