Ask about this productRelated genes to: Csnk1g1 antibody
- Gene:
- CSNK1G1 NIH gene
- Name:
- casein kinase 1 gamma 1
- Previous symbol:
- -
- Synonyms:
- CK1gamma1
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-31
- Date modifiied:
- 2016-10-05
Related products to: Csnk1g1 antibody
Related articles to: Csnk1g1 antibody
- Human organoids that mirror their corresponding organs in cell-type diversity present an opportunity to perform large-scale screens for compounds that protect disease-affected or damaged healthy cell types. Here, we generated 20,000 human retinal organoids with green fluorescent protein (GFP)-labeled cone photoreceptors. Since degeneration of cones is a leading cause of blindness, we induced cone death and screened 2,707 compounds with known targets for those that saved cones or those that further damaged cones. We identified inhibitors of casein kinase 1 (CK1) that protected cones, heat shock protein 90 (HSP90) inhibitors that saved cones in the short term but damaged them in the longer term, and broad histone deacetylase (HDAC) inhibition by many compounds that significantly damaged cones. Finally, we confirmed the protective effects of identified compounds in a mouse model of photoreceptor degeneration. This work provides a database for cone-damaging compounds and describes compounds and targets that can be starting points to develop neuroprotection for cones in diseases such as macular degeneration. - Source: PubMed
Publication date: 2026/03/30
Spirig Stefan EHerrero-Navarro ÁlvaroUtz LarissaArteaga-Moreta Valeria JRaics ZoltanPosada-Céspedes SusanaChreng StephanieGaluba OlafGaluba IngaClaerr IsabelleRenner SteffenBoldogkoi MiklosMoreno-Juan VerónicaKleindienst P TimoVolak AdriennImbach JannickMalysheva SvitlanaSiwicki Rebecca AHahaut VincentHou YanyanRodrigues Tiago MPicelli SimoneCattaneo MarcoJüttner JosephineCowan Cameron SDuckely MyriamBaeschlin Daniel KRenner MagdalenaUnterreiner VincentRoska Botond - Runs of homozygosity (ROH) are continuous stretches of homozygous loci generated from identical haplotypes inherited from a common ancestor. ROH hotspots could be an indicator of footprints from artificial and/or natural selection processes. Here, genomic information of 937 individuals from commercial Saanen herds selected in Brazilian tropical environments was used to characterize the population genetic diversity through a genome-wide assessment of autozygosity and effective population size (Ne), in addition to investigate ROH hotspots for pinpointing genomic regions subjected to selective pressures in Saanen in the tropics. Inbreeding levels are relatively under control in this population, but the Ne estimate above but close to 50 animals would be considered critical for this population to be long-term viable in terms of genetic diversity, demanding extra attention on Ne monitoring by the breeders. Nine ROH hotspots were identified on chromosomes 7, 10, 11, 12, 13, 14, 18, and 24, harboring genes directly related to production and adaptive traits. This includes genes associated with milk and protein yield and somatic cell count (CSNK1G1, PCLAF, TRIP4, ZNF609, OAZ2, PIF1, PLEKHO2, and PTGDR); reproduction (ZNF609, OAZ2, PTGDR, GJA3, GJB2, and GJB6); adaptation to heat stress (HSPA9, SIL1, CTNNA1, RNF17, ZMYM2, PARP4, and XPO4); immune system response to mastitis and other infections (HCK, BPIFA1, and BPIFB1), among others. The various loci directly related to the genetic control of productive and adaptive traits in goats identified in this study suggest possible footprints from artificial and/or natural selection processes related to adaptability of Saanen to tropical production systems. - Source: PubMed
Publication date: 2025/11/03
Fernandes Júnior Gerardo Alvesda Silva Marcos Vinicius Gualberto BarbosaLobo Ana Maria Bezerra OliveiraPanetto João Cláudio do Carmode Moraes Silva KleibePaiva Samuel RezendeFacó Olivardo - In light of the challenges posed by global climate change, the environmental adaptability of organisms is becoming increasingly important. The Wuzhishan (WZS) pig, tolerant to high heat and humidity, is an ideal model for genomic study. By characterizing its genome and assessing its genetic diversity and runs of homozygosity (ROH), we can gain insights into its current conservation status and genomic architecture. To this end, we analyzed whole-genome resequencing data from WZS pigs, identifying a comprehensive set of genetic variations: 12,844,858 single nucleotide polymorphisms (SNPs), 4,723,303 insertions and deletions (InDels), 39,311 copy number variations (CNVs), and 70,392 structural variations (SVs). ROH analysis revealed mostly short segments, indicating limited recent admixture and relatively low inbreeding, reflecting high genetic diversity. Linkage disequilibrium decay and effective population size analyses supported these findings, consistent with previous studies. Population genetic analyses of pig populations from Asia, Europe, and the Americas were conducted using SNPs, InDels, and SVs. The results obtained from different variant types were largely concordant, suggesting that the constructed genomic variation database is robust. Notably, the WZS pig displayed relatively unique genetic characteristics compared to other breeds. By intersecting the top 5 % of genes under selection signatures, we identified key pathways and candidate genes associated with important traits in WZS pigs, including reproduction (ABCC9, APC2, CABS1, CSNK1G1), immunity (ARPIN, CMAS, ITPR1, SLC25A13), meat quality (GANC, OBSCN, SLC5A4), environmental adaptability (MAGI1, PHF3), and heat tolerance (GABPB1, LRRC25). Further integrative analyses based on transcriptomic, single-cell transcriptomic, and epigenomic data were conducted to explore the regulatory mechanisms of key genes such as LRRC25 and ITPR1. We identified relevant expression quantitative trait loci (eQTLs), associated tissues, and distal regulatory elements that potentially influence gene expression. These findings suggest that epigenetic modifications may contribute to the enhanced heat tolerance and immune function observed in WZS pigs. In conclusion, WZS pigs represent a valuable genetic resource. Further research on this breed will deepen our understanding of mechanisms underlying environmental adaptability, and provide important insights into evolutionary biology and breeding strategies for improved resilience in livestock. - Source: PubMed
Publication date: 2025/09/04
Zhong ZiqiWang FengXie XinfengWang ZiyiPan DeyouWang ZhenXiao Qian - Spermiogenesis is the committed step of sperm production, during which spermatid cells undergo dramatic morphological transformations and transcriptional silencing. Post-translational modifications (PTMs), including phosphorylation, provide a level of protein function flexibility and play important roles in spermiogenesis. Dynamic protein phosphorylation profiles of spermatids are characterized across four different developing steps, and identified phosphorylation regulation of key proteins in spermiogenesis. Expression module and kinase-substrate phosphorylation network analysis revealed significant kinase activities of CSNK1G1 and TTBK2. CSNK1G1 is localized in the acrosome and is indispensable for acrosome biogenesis. Ttbk2 male germ cell conditional knockout mice are infertile with flagella development and head shaping defects. TTBK2 is essential for both the phosphorylation and stabilization of IFT88, an intraflagellar transport (IFT) protein with which TTBK2 colocalizes and interacts. Ciliogenesis defects in Ttbk2 knockout cells can be rescued by overexpression of TTBK2 or IFT88 but not kinase-dead TTBK2. Collectively, the systematic profiling of the spermiogenesis phosphoproteome revealed the dynamic nature and important functions of kinase phosphorylation in spermiogenesis and male fertility. - Source: PubMed
Publication date: 2025/09/03
Zhu TianyuZhu YanJiang XinyiZhang XiangzhengWang BingChen YuZhao YichenWang YulianZhou QiHan ZhongyanQi YalingLuo MengjiaoTu HaixiaHao BingjieGao MengmengRen JieZhou XinZhang XingyuChen XuLi HaojieHuang QianSitu ChenghaoGuo YueshuaiZhu HuiLi YanGuo Xuejiang - The reproductive performance of horses is closely associated with testicular development, which involves a complex network of gene regulation. The molecular mechanisms underlying the reproductive traits of Kazakh horses are yet to be fully understood. In this study, transcriptomic analysis was performed on testicular tissues from Kazakh horses at different developmental stages using whole-transcriptome sequencing, aiming to investigate differential gene expression and regulatory mechanisms during testicular development. The results revealed significant differential expression of 7678 mRNAs, including COL4A1, LGR6, and WNT4, 4569 long non-coding RNAs (LncRNAs), 4148 circular RNAs (circRNAs) such as CSNK1G1, CUL3, and CSNK1G3, and 1091 microRNAs (miRNAs) including eca-miR-1197, eca-miR-122, and eca-miR-138. GO and KEGG enrichment analyses indicated that these differentially expressed genes (DEGs) are primarily involved in biological regulation (BP), cellular part (CC), binding (MF), as well as key signaling pathways such as the Wnt signaling pathway, PI3K-Akt signaling pathway, and mTOR signaling pathway. Additionally, the construction of a competing endogenous RNA (ceRNA) regulatory network highlighted the potential regulatory roles of non-coding RNAs in testicular development. This study provides a theoretical basis for analyzing the molecular mechanisms of testicular development in Kazakh horses and offers candidate molecular markers for the genetic improvement of equine reproduction. - Source: PubMed
Publication date: 2025/07/22
Lu ZhixinWen MingyueYao XinkuiMeng JunWang JianwenZeng YaqiLi LinlingRen Wanlu