Ask about this productRelated genes to: NFAT5 antibody
- Gene:
- NFAT5 NIH gene
- Name:
- nuclear factor of activated T cells 5
- Previous symbol:
- -
- Synonyms:
- TONEBP, KIAA0827, NFATL1, OREBP, NFATZ, NF-AT5
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-16
- Date modifiied:
- 2019-04-23
Related products to: NFAT5 antibody
Related articles to: NFAT5 antibody
- This study aimed to investigate the regulatory role of circular RNAs (circRNAs) in lupus nephritis (LN) and to explore their potential mechanisms. - Source: PubMed
Publication date: 2026/04/24
Gong SiwenWang ChongyaoEmiliia GainetdinovaFu YutingDing XiaotongHe WenyaZhang LeiLiu RuichanWang XingzhiBao YushiSui Manshu - Diabetes is a chronic inflammatory disease that may damage the blood-retinal barrier, leading to diabetic retinopathy (DR). Blood-retinal barrier rupture may subject the retinal pigmented epithelial cells to a hyperosmolar stress (HOS), activating the transcription factor nuclear factor of activated T cells 5 (NFAT5). In addition, inflammatory cytokines, such as monocyte chemoattractant protein 1 (MCP-1/CCL2), play a crucial role in DR. The aims of our study were to determine whether HOS induces MCP-1 levels in arising retinal pigmented epithelial 19 (ARPE-19) cells and to decipher the responsible intracellular cascade involved in such stimulation. - Source: PubMed
Publication date: 2025/10/05
Hamou Moncef OuldMasset MaureenWeber CéliaScifo LisaLibert SarahBryla AngélicGregoire FrançoiseDelforge ValérieBolaky NargisDatlibagi AzineSpringael Jean-YvesPerret JasonWillermain FrançoisDelporte Christine - Comb and skin pigmentation are key external traits in domestic chickens, closely correlated and serving as important visual cues for consumers. The Anyi Gray chicken, an indigenous breed from Jiangxi Province, China, exhibits two stable phenotypes: red comb with white skin (RAY), and purple-gray comb with purple-gray skin (PAY). Although skin color is completely linked to comb color, the genetic basis of this coordination remains unclear. We performed whole-genome resequencing (∼ 10 × depth) on RAY and PAY individuals, followed by a case-control genome-wide association study (GWAS). A highly significant variant, g.10818413 T > C, located in the promoter region of EDN3, was identified (P < 4.065343e-09). Transcription factor binding site prediction revealed that this mutation disrupts an NFAT5 binding site. Genotyping of 97 Anyi Gray chickens showed complete concordance between genotype and phenotype: all PAY individuals carried the TC genotype, while all RAY individuals had the TT genotype; no CC genotypes were detected. Validation in an F1 hybrid population (n = 61) and in 140 individuals from other Jiangxi native breeds confirmed the absence of the CC genotype. Functional assays demonstrated that NFAT5 negatively regulates EDN3 transcription. Dual-luciferase reporter assays confirmed NFAT5 binding to the EDN3 promoter and its suppressive effect. Tissue expression analysis showed significantly higher EDN3 expression in the comb, skin, and chest muscle of PAY individuals compared to RAY individuals, reinforcing the phenotypic linkage. These findings indicate that the EDN3 g.10818413 T > C mutation reduces NFAT5 binding affinity, cis-regulating EDN3 transcription and driving the coordinated pigmentation of the comb and skin. This study reveals a shared regulatory mechanism underlying the phenotypic correlation between comb and skin pigmentation in Anyi Gray chickens. - Source: PubMed
Publication date: 2026/02/26
Huang JianxiCheng DiXi SuwangWang ZunTu YunHuang SixiangWu DongxiaoZhang ZengweiJiang HongxiaHu XiaolongChen BiaoLiu SanfengMao Huirong - Clinical trials have indicated that finerenone, a nonsteroidal mineralocorticoid receptor antagonist, elicits considerable cardiovascular protective benefits; however, its precise mechanism of action remains to be fully elucidated. - Source: PubMed
Publication date: 2026/03/04
Rahman AsadurSawano TatsuyaKitada KentoJahan NourinFujisawa YoshihideYamakawa KeikoRahman Md MoshiurYe JuanjuanKabir Md EnayetKadota KyuichiImamura TakeshiOhsaki HiroyukiYamazaki DaisukeMorikawa TakashiKonishi YoshioNishiyama Akira - Allergic rhinitis (AR) affects 10-40% of the world's population, and modern high-salt diets (HSD) may influence immune function. Currently, the influence and mechanism of a HSD on AR remain poorly understood. The study aims to investigate the role of a HSD in AR through the P38/MAPK-NFAT5-SGK1 signaling pathway. The serum IgE levels, 24-hour urinary sodium excretion, and AR symptom scores in patients were detected. To evaluate the immune responses and potential pathway, ovalbumin-induced AR mice were exposed to a HSD. Cellular gene silencing technology was employed to identify key regulators of the NFAT5 pathway. In AR patients, urinary sodium excretion was positively correlated with IgE levels and symptom scores. In the mouse model, a HSD altered the gut microbiota and upregulated NFAT5 expression, leading to nasal mucosal barrier disruption and inflammation exacerbation. Gene-silencing experiments confirmed the critical role of the P38/MAPK-NFAT5-SGK1 pathway in mediating both allergic responses and epithelial damage. Notably, switching from a HSD to a normal diet partially reversed clinical symptoms in mice, but the immune memory remained difficult to reset. In conclusion, this work provides the strong evidence of salt-immune axis in AR through osmotic sensing pathways, advancing mechanistic understanding and clinical management approaches. - Source: PubMed
Publication date: 2026/03/03
Jiang LanWang YuxinHuang JingYao SiyuYao YuanhangZeb AurangRaghavan VijayaCheng LeiWang Jin