Ask about this productRelated genes to: APOL6 antibody
- Gene:
- APOL6 NIH gene
- Name:
- apolipoprotein L6
- Previous symbol:
- -
- Synonyms:
- APOL-VI, APOLVI
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-21
- Date modifiied:
- 2015-12-15
Related products to: APOL6 antibody
Related articles to: APOL6 antibody
- After spinal cord injury (SCI), neuronal lipid peroxidation and excessive production of reactive oxygen species (ROS) induced by secondary injury exacerbate ferroptosis, impeding regenerative repair and functional recovery in mice. Thus, clarifying the molecular and cellular mechanisms underlying the inhibition of neuronal ferroptosis post-SCI is crucial. - Source: PubMed
Xi XiaolongChen ZhensenWang ChaojunWang FeiSun Xuedong - To explore the mechanism of cuprotosis in psoriasis, screen cuprotosis related genes (PDCRGs) in psoriasis, and provide new targets for precise diagnosis and treatment of psoriasis. - Source: PubMed
Publication date: 2025/12/13
Ma YingyingSun YingYao JintongZhang JianWang HailiangYang Suqing - Prediction of outcomes of SARS-CoV-2 infection remains challenging, particularly in the early days following exposure. To better understand the heterogeneity of disease progression, we investigated the early immune response in the upper respiratory tract using transcriptomic analysis, comparing individuals who remained asymptomatic to those who developed symptoms of COVID-19. We conducted a study of 74 individuals (43 children, 31 adults) with confirmed SARS-CoV-2 infection. Mid-turbinate nasal swabs were collected during the first few days of infection and again one week later. We performed a paired analysis comparing baseline and follow-up nasal human gene expression. Additionally, we conducted a predictive analysis to identify transcripts associated with the development of symptomatic infection. From the differentially expressed transcripts in both analyses, we developed a predictive model to assess the likelihood of symptomatic disease. We also compared gene expression patterns between children and adults. A robust interferon response in the upper respiratory tract was strongly associated with the development of symptomatic infection. A panel of five interferon-stimulated genes (TAP2, DDX60, IFIT5, APOL6, and IFI6) predicted symptomatic infection with reasonable accuracy (area under the curve = 0.84). Notably, adaptive immune responses, including T-cell activation and cytokine signaling, differed substantially between children and adults. Our findings suggest that early measurement of interferon-stimulated gene expression may help identify individuals at risk of developing symptomatic COVID-19. - Source: PubMed
Publication date: 2025/12/05
Yue MolinLee SojinTao ShiyueTomazetto GeizeclerYahner KristinLiu HuiLee Matthew CNowalk Mary PatriciaZimmerman Richard KJohnson MonikaMacDonald WilliamForno ErickChen WeiShaikh Nader - We report a 15-year-old female with hypoplastic left heart syndrome and a strong family history of congenital heart defects. Quad genome sequencing was performed following negative chromosomal microarray and congenital structural heart disease gene panel testing, revealing a heterozygous 144 kb deletion encompassing exons 4-14 of RBFOX2, the entirety of the APOL5 gene, and exon 3 of APOL6 in all affected family members. Although RBFOX2 has been implicated in causing hypoplastic left heart syndrome in animal models, and variants in this gene are enriched in patients with congenital heart disease, this report establishes loss-of-function variants in RBFOX2 as an autosomal dominant cause of hypoplastic left heart syndrome. Furthermore, this case highlights the power of genome sequencing in identifying causative variants in patients who have received nondiagnostic array and panel testing. - Source: PubMed
Publication date: 2025/10/29
Jean FrancescaStuart AmandaMarcadier JulienBernier Francois PLamont Ryan E - Necroptosis plays a critical role in the onset and progression of numerous malignancies, with colorectal cancer (CRC) ranking among the leading causes of cancer-related mortality worldwide. However, the relationship between necroptosis-related genes (NRGs) and CRC remains contentious. Hence, this study aims to develop a novel NRG-based signature to predict the prognosis of CRC patients and explore its potential role. - Source: PubMed
Publication date: 2025/09/01
Tan LuluWang ShuaifengChang WeilongZhang XiaoyingDeng RuiYan HuifangZhu WeiweiWang HuifenCai YudieLiu ZhiboTan YuyanCui Jinyuan