Ask about this productRelated genes to: ZNF529 antibody
- Gene:
- ZNF529 NIH gene
- Name:
- zinc finger protein 529
- Previous symbol:
- -
- Synonyms:
- KIAA1615
- Chromosome:
- 19q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-02
- Date modifiied:
- 2016-10-05
Related products to: ZNF529 antibody
Related articles to: ZNF529 antibody
- Hepatocellular carcinoma (HCC) remains a significant global health concern. Zinc finger protein 529 (ZNF529) may be associated with resistance to tyrosine kinase inhibitors (TKIs) in HCC. This study explored the expression of ZNF529 in HCC, its prognostic significance and its potential as a therapeutic target. We aimed to evaluate how the up-regulation of ZNF529 correlates with disease prognosis and drug resistance in HCC. - Source: PubMed
Publication date: 2025/10/27
Qin KaiZhou Sheng-ShengLi Jian-DiQin Di-YuanZeng Da-TongHuang Wan-YingHuang Zhi-GuangYao Gao-PengChen Yu-ZhenYin Bin-TongLi Fu-XiWang LeiChen GangHe Rong-Quan - To explore the feasibility and clinical application value of differentially expressed lncRNA in human peripheral blood mononuclear cell (PBMC) as a potential biomarker for postmenopausal osteoporosis (PMOP). In this study, a case-control trial was conducted to collect a total of 10 samples of PBMC from PMOP and postmenopausal-without-osteoporosis (n-PMOP) patients. RNA sequencing was performed to profile lncRNA and mRNA expression, identifying differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) based on the criteria of fold change (FC) ≥ 2 and value < 0.05; GO and KEGG enrichment analyses were carried out for differentially expressed genes (DEGs); 10 DElncRNAs and 20 DEmRNAs were selected for lncRNA-mRNA correlation analysis and Circos plot to screen out the lncRNAs that could be used as potential biomarkers. Then, ROC curve analysis was used to evaluate the diagnostic and therapeutic value of DElncRNAs as clinical potential diagnostic markers for PMOP. Afterward, 20 PMOP and 20 n-PMOP patients were reincluded and quantitative real-time PCR (qRT-PCR) was performed to externally validate the screening of lncRNAs. (1) Compared with n-PMOP, there were 1978 DElncRNAs and 1024 DEmRNAs in PMOP patients. (2) Bioinformatics technology was used to analyze the DEGs, and the GO analysis showed that the activities of the gene products were mainly related to the protein binding, membrane, plasma membrane, and extracellular region. The results of KEGG enrichment analysis showed that it was mainly enriched in PI3K-Akt signaling pathway, metabolic pathways, and pathways in cancer and focal adhesion. (3) The correlation network and Circos plot further indicated the implication of DElncRNA expression profiles in PMOP via interactions with DEmRNAs. Among them, lncRNA RAB37, lncRNA BEGAIN, and lncRNA ZNF529 had the highest number of nodes, totaling 19, possibly potential diagnostic markers for PMOP. (4) The diagnostic efficacy of the screened lncRNAs was analyzed by ROC curve. The results showed an the area under the ROC curve (AUC) of 0.960 for lncRNA RAB37, 1.000 for lncRNA ZNF529, 1.000 for lncRNA BEGAIN. (5) The qPCR results showed that lncRNA RAB37, lncRNA ZNF529, and lncRNA BEGAIN were all significantly correlated with the occurrence of PMOP ( < 0.05). However, the significant difference of lncRNA ZNF529 was superior to that of other lncRNAs. The lncRNA ZNF529 is significantly overexpressed in PBMC in PMOP, and bioinformatics analysis and validation experiments indicate that it is closely associated with PMOP; thus, it is expected to be a potential diagnostic marker for PMOP. - Source: PubMed
Publication date: 2024/11/23
Yihua ZhuChenjian PengLining WangShujun JiangHaomiao YangKaixuan ZhangFenglei DaiYong MaXudong ChuChunlei ZhangHaitao Sun - Osteoarthritis (OA) is a serious threat to human health. However, the etiology and pathogenesis of the disease are not fully understood. Most researchers believe that the degeneration and imbalance of articular cartilage, extracellular matrix, and subchondral bone are the fundamental causes of osteoarthritis. However, recent studies have shown that synovial lesions may precede cartilage, which may be an important precipitating factor in the early stage of OA and the whole course of the disease. This study aimed to conduct an analysis based on sequence data from the Gene Expression Omnibus (GEO) database to investigate the presence of effective biomarkers in the synovial tissue of osteoarthritis for the diagnosis and control of OA progression. In this study, the differentially expressed OA-related genes (DE-OARGs) in osteoarthritis synovial tissues were extracted in the GSE55235 and GSE55457 datasets using the Weighted Gene Co-expression Network Analysis (WGCNA) and limma. Least-Absolute Shrinkage and Selection Operator (LASSO) algorithm was used to select the diagnostic genes based on the DE-OARGs by glmnet package. 7 genes were selected as diagnostic genes including SAT1, RLF, MAFF, SIK1, RORA, ZNF529, and EBF2. Subsequently, the diagnostic model was constructed and the results of the Area Under the Curve (AUC) demonstrated that the diagnostic model had high diagnostic performance for OA. Additionally, among the 22 immune cells of the Cell type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) and the 24 immune cells of the single sample Gene Set Enrichment Analysis (ssGSEA), 3 immune cells and 5 immune cells were different between the OA and normal samples, respectively. The expression trends of the 7 diagnostic genes were consistent in the GEO datasets and the results of the real-time reverse transcription PCR (qRT-PCR). The results of this study demonstrate that these diagnostic markers have important significance in the diagnosis and treatment of OA, and will provide further evidence for the clinical and functional studies of OA. - Source: PubMed
Publication date: 2023/03/16
Zhu Yun-SenYan HongMo Ting-TingZhang Jiang-NanJiang Chang - Invasion and metastasis of hepatocellular carcinoma (HCC) is still an important reason for poor prognosis. LincRNA ZNF529-AS1 is a recently identified tumour-associated molecule that is differentially expressed in a variety of tumours, but its role in HCC is still unclear. This study investigated the expression and function of ZNF529-AS1 in HCC and explored the prognostic significance of ZNF529-AS1 in HCC. - Source: PubMed
Publication date: 2023/02/17
Ma YangSun Wan-LiangMa Shuo ShuoZhao GuanruLiu ZhongLu ZhengZhang Dengyong - Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function. We identify 76 (11 previously unreported) presumed causal protein-altering variants associated with one or more CVD- or liver-related blood traits. Nine of the variants are predicted to result in loss-of-function of the protein. This includes ZNF529:p.K405X, which is associated with decreased low-density-lipoprotein (LDL) cholesterol (P = 1.3 × 10) without being associated with liver enzymes or non-fasting blood glucose. Silencing of ZNF529 in human hepatoma cells results in upregulation of LDL receptor and increased LDL uptake in the cells. This suggests that inhibition of ZNF529 or its gene product should be prioritized as a novel candidate drug target for treating dyslipidemia and associated CVD. - Source: PubMed
Publication date: 2020/12/18
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