Ask about this productRelated genes to: PRDM9 antibody
- Gene:
- PRDM9 NIH gene
- Name:
- PR/SET domain 9
- Previous symbol:
- MSBP3
- Synonyms:
- PFM6, ZNF899, KMT8B
- Chromosome:
- 5p14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2016-11-03
Related products to: PRDM9 antibody
Related articles to: PRDM9 antibody
- - Source: PubMed
Publication date: 2026/08/28
Pratto Florencia - Meiotic recombination is a fundamental process that generates genetic diversity by creating new combinations of existing alleles. Whereas crossovers in humans are well characterized, the more frequent non-crossovers that lead to gene conversion remain challenging to study. Here we show that single high-fidelity long sequencing reads from sperm can capture both crossovers and non-crossovers, which enables effectively arbitrary sample sizes for analysis from a single male. We analysed 2,382 candidate non-crossovers in 15 sperm samples from 13 donors, and identified a consistent component with properties distinct from PRDM9-induced recombination. This phenomenon was not associated with meiotic double-strand break sites identified by DMC1 binding, the crossover recombination map or GC-biased gene conversion, but was associated with genomic fragile sites. This component is also seen in paternal non-crossover gene conversions in pedigree data. Applying the same analysis to 12 blood samples, we observed non-crossover gene conversions with similar properties, but very few crossover events. Further, we demonstrate variation between donors for the different types of recombination, even when they share the same PRDM9 genotype. We suggest that a substantial fraction of the non-crossover gene conversion events seen in sperm arise prior to meiosis. - Source: PubMed
Publication date: 2026/08/26
Schweiger RegevLee SangjinZhou ChenxiYang Tsun-PoLi StacySanghvi RasheshNeville MatthewSmith KatieRoberts KirstyNessa AyrunWadge SamSmall Kerrin SCampbell Peter JAlmstrup KristianSudmant Peter HRahbari RahelehDurbin Richard - Hybrid sterility arises when two fully fertile populations produce sterile offspring, representing a key postzygotic barrier to gene flow between emerging species. In the sterile hybrid males of (, represented by the C57BL/6J strain, hereafter B6) and (, represented by the wild-derived PWD/Ph strain), meiotic prophase I exhibits extensive autosomal asynapsis, pachytene arrest, and an absence of mature spermatozoa. This sterility results from allelic incompatibility, which is modulated by the X-linked locus, recently identified as the microRNA. While this two-locus incompatibility is the major cause of sterility, additional modifiers may further contribute to the phenotype. In particular, the DNA mismatch repair protein MSH2 recognizes DNA sequence heterology and enforces anti-recombination in yeast. This raises the possibility that could amplify the effects of subspecific sequence divergence in mouse hybrids. - Source: PubMed
Publication date: 2026/07/12
Fusek KarelJansa PetrForejt Jiri - Along with germline mutations, meiotic recombination plays a fundamental role in shaping genetic diversity and thus directly influences a species' potential adaptive response to environmental change, amongst other features. Despite the recombination landscape being of central importance for a variety of questions in molecular evolution, the genome-wide distribution and frequency of recombination remains to be elucidated in many nonhuman primate species. Utilizing novel high-coverage genomic data from three multi-sibling families, we here provide the first estimates of the rates and patterns of crossover and noncrossover recombination in coppery titi monkeys (Plecturocebus cupreus)-a socially monogamous, pair-bonded primate that serves as an important model in behavioral research. Consistent with haplorrhines, crossover and noncrossover recombination in this platyrrhine are frequently localized at PRDM9-mediated hotspots, characterized by a 15-mer binding motif with substantial similarities to the degenerate 13-mer motif found in humans. The sex-averaged crossover rate in coppery titi monkeys is comparable with those of other primates; however, no significant difference in recombination rates was observed between the sexes, despite a pronounced maternal age effect in the species. Similarities also exist with regards to the sex-specific genomic distribution of noncrossover events, though the minimal conversion tract lengths of extended events was observed to be considerably longer in maternally inherited noncrossovers. Taken together, these similarities and differences in the recombination landscape relative to other primates highlight the importance of incorporating species-specific rates and patterns in evolutionary models, and the resources provided here will thus serve to aid future studies in this important primate model system. - Source: PubMed
Versoza Cyril JBales Karen LJensen Jeffrey DPfeifer Susanne P - Teleosts (teleost fishes), comprising over 30,000 species-roughly half of all living vertebrates-exhibit remarkably diverse patterns of meiotic recombination. Recent genome-wide analyses as well as cytological studies provide new insights built on decades of genetic research. In most teleosts, crossovers are concentrated near chromosome ends, producing strong heterochiasmy largely driven by male meiosis. Despite sharing conserved recombination machinery with mammals, teleosts show strikingly relaxed meiotic checkpoints, allowing meiotic progression and gamete formation even with severe recombination defects. This tolerance likely facilitates hybridization, polyploidy, and clonal reproduction commonly observed in teleosts. The recombination hotspot regulator PRDM9 has diversified dramatically across teleost lineages: some retain the full-length Prdm9α that determines recombination hotspots, whereas most species possess only a truncated Prdm9β and likely rely on PRDM9-independent recombination. Cytological analyses further reveal dynamic synapsis and partial recombination suppression on emerging sex chromosomes. This review summarizes the current understanding of meiotic recombination in teleost fishes, integrating evidence from recombination landscape diversity, molecular pathways, cytological features, PRDM9 evolution, and distinctive phenomena such as sex chromosome differentiation, clonal reproduction, hybridization, polyploidy tolerance, and relaxed checkpoint control. Together, these findings illustrate how the remarkable lineage-specific adaptations of teleosts can serve as a powerful lens for revealing the fundamental significance of meiotic recombination across vertebrates. - Source: PubMed
Imai Yukiko