Ask about this productRelated genes to: ZNF226 antibody
- Gene:
- ZNF226 NIH gene
- Name:
- zinc finger protein 226
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-08-13
- Date modifiied:
- 2015-09-09
Related products to: ZNF226 antibody
Related articles to: ZNF226 antibody
- Delirium is a prevalent neuropsychiatric syndrome affecting up to 50% of hospitalized elderly patients, associated with increased mortality, cognitive decline, and health care costs exceeding $164 billion annually. Despite its clinical burden, the genetic architecture underlying susceptibility to delirium remains poorly characterized. We developed an agentic artificial intelligence pipeline integrating genome-wide association study (GWAS) data from FinnGen Release 12 (6854 cases; 384,461 controls) with causal transcriptome-wide association study (cTWAS) using brain-specific eQTL data from Genotype-Tissue Expression. Spatial transcriptomics analysis (gsMap) was performed on the human dorsolateral prefrontal cortex to characterize layer-specific expression patterns. Deep learning models (Enformer, SpliceTransformer) were applied to predict functional consequences of identified variants. GWAS identified a strongly associated locus on chromosome 19q13.32, with lead variant rs429358 ( = 2.79 × 10) defining the apolipoprotein E () ε4 allele. cTWAS analysis identified two causal genes: (posterior inclusion probabilities [PIP] = 0.871, = -8.44) and (PIP = 0.604, = 5.63), exhibiting opposite directional effects. downregulation increased susceptibility to delirium, while upregulation conferred an elevated risk. Spatial transcriptomics revealed significant GWAS enrichment in Layer 5 ( < 0.001), with distinct layer-specific expression patterns for both genes. Enformer predicted that rs429358 substantially altered chromatin accessibility at promoter regions (H3K4me3 SNP Activity Difference = 0.30). SpliceTransformer identified significant splice site perturbations (maximum Δ = 0.45). This study provides a comprehensive genetic dissection of delirium through agentic artificial intelligence-driven multiomics integration. We identify and as causal genes with distinct mechanisms and spatial expression patterns. These findings establish a molecular framework for understanding delirium pathophysiology and identify potential therapeutic targets. - Source: PubMed
Publication date: 2026/06/29
Yang JidongWang XiongPeng LishuangTang JianfuCai ShanshanXue Yuting - The Kazakh horse is a highly valuable indigenous Chinese breed known for its use in both milk and meat production. However, the mechanisms underlying color variation in the abdominal adipose tissue of this breed remain poorly understood. In this study, the sequencing of non-coding RNAs (ncRNAs) was conducted on abdominal adipose tissue of different colors from Kazakh horses, with the aim of investigating the molecular mechanisms responsible for this variation. A total of 205 differentially expressed long non-coding RNAs (DELncRNAs) including , , and ; 52 differentially expressed microRNAs (DEmiRNAs) including and ; and 559 differentially expressed circular RNAs (DEcircRNAs) including and , were identified between Group W and Group Y. GO annotation and KEGG enrichment analyses of the DEGs revealed that these genes were primarily involved in biological processes such as chemical homeostasis (biological process, BP), intracellular components (cellular component, CC), and iron-sulfur cluster binding (molecular function, MF) as well as in metabolic pathways related to lipid biosynthesis and metabolism including vitamin B6 metabolism, tryptophan metabolism, and glycerolipid metabolism. The sequencing accuracy was further validated using reverse transcription quantitative PCR (RT-qPCR). This study identified key DEGs and signaling pathways associated with the color variation in adipose tissue of Kazakh horses and sheds light on the regulatory genes and biological processes involved. These findings provide a theoretical basis and research foundation for future studies on color variations in the adipose tissue of equine species. - Source: PubMed
Publication date: 2025/09/17
Zhou YuheYao XinkuiMeng JunWang JianwenZeng YaqiLi LinlingRen Wanlu - DNA methylation has recently been identified as a mediator between in utero famine exposure and a range of metabolic and psychiatric traits. However, genome-wide analyses are scarce and cross-sectional analyses are hampered by many potential confounding factors. Moreover, causal relations are hard to identify due to the lack of controlled experimental designs. In the current study, we therefore combined a comprehensive assessment of genome-wide DNA methylation differences in people exposed to the great Chinese famine in utero with an in vitro study in which we deprived fibroblasts of nutrition. - Source: PubMed
Publication date: 2019/05/16
He Yujiede Witte Lot DHoutepen Lotte CNispeling Danny MXu ZhidaYu QiongYu YaqinHol Elly MKahn René SBoks Marco P - Glioblastomas (GBMs) are the most prevalent brain tumor and exhibit poor prognosis. Radiotherapy is an important strategy for GBMs patients; however, this care remains palliative because of GBMs' radioresistance. Glioma stem cells (GSCs), as a subpopulation residing at the apex of the hierarchy, have been believed to be a pivotal population in radioresistance and recurrence of GBMs. To know the key genes involved in radioresistance of GSCs, the gene expression profiles of GSE54660 and GSE60921 were downloaded from Gene Expression Omnibus for genetic and transcriptomic analysis to identify the potential biomarker genes differentially expressed between GSCs and GBMs. These candidate genes were then filtered by the GSCs gene profile responding to radiation and the radioresistant biomarker genes including , , , , , and were screened. The differentially expressed genes in GSCs post-irradiation were submitted to Gene Ontology (GO) for further enrichment analysis and protein-protein interaction (PPI) network analysis. A significant module correlated with was finally chosen and a series of genes participating in DNA metabolism were identified. In conclusion, this study propounds a set of novel genes that are differentially expressed in the radioresistant subpopulation within GBMs and could serve as promising therapeutic targets. - Source: PubMed
Publication date: 2019/03/11
Wang ChenZheng WangYao DanChen QianpingZhu LinZhang JunlinPan YanZhang JianghongShao Chunlin