Ask about this productRelated genes to: Trpv6 antibody
- Gene:
- TRPV6 NIH gene
- Name:
- transient receptor potential cation channel subfamily V member 6
- Previous symbol:
- ECAC2
- Synonyms:
- CaT1
- Chromosome:
- 7q34
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-24
- Date modifiied:
- 2016-01-28
Related products to: Trpv6 antibody
Related articles to: Trpv6 antibody
- Despite extensive research, a consolidated synthesis of electrolyte regulation and related channelopathies in sperm biology remains limited. This scoping review maps global evidence on ionic homeostasis and male fertility. - Source: PubMed
Publication date: 2026/05/07
Twambaze Marie FrancoiseAdebayo Ismail AbiolaOdoma SaidiAlagbonsi Abdullateef Isiaka - The low yield of high-activity calcium-binding peptides constitutes a technical bottleneck restricting their application. Herein, a static affinity chromatography approach using needle-shaped hydroxyapatite was developed for the isolation of a novel cod bone calcium-binding peptide, GRGNEGPQ (CBP-8). The calcium-binding mechanism was investigated using experimental and computational methods, while its digestive behavior and calcium transport effects were evaluated using an in vitro digestion model and Caco-2 cell monolayer model. Results indicated that the carboxyl group of Gln served as a potential calcium-binding site and the CBP-8-Ca complex formed through multiple chelation modes. Electrostatic interactions were critical for coordination bond formation, with a formal charge transfer of -2.13 e from Ca in the CBP-8-Ca complex. CBP-8-Ca exhibited good gastric stability but degraded intestinally. Additionally, CBP-8 promoted Ca transport via non-specific calcium channels and TRPV6 channels. This study offers a promising and cost-effective strategy for the efficient production of highly active calcium-binding peptides. - Source: PubMed
Publication date: 2026/04/17
Tian QiaojiHao LiFan ChaozhongHou Hu - Hereditary chronic pancreatitis (CP) is associated with elevated risk of pancreatic ductal adenocarcinoma (PDAC), but the specific contributing genes and their associated risk magnitudes remain incompletely defined. We aimed to investigate whether pathogenic germline variants (PGVs) in all 11 known CP-associated genes (CASR, CEL, CFTR, CLDN2, CPA1, CPB1, CTRC, PNLIP, PRSS1, SPINK1, TRPV6) predispose to PDAC and to quantify their risk estimates. - Source: PubMed
Publication date: 2026/04/20
Antwi Samuel ORabe Kari GCarlson Erin ESicotte HuguesBamlet William RMills Krystal CKonikoff Tom McWilliams Robert ROberg Ann LMajumder Shounak
- Source: PubMed
- This study investigated the effects of dietary supplementation with α-mangostin (α-Ma), a bioactive xanthone derived from mangosteen pericarp, on production performance and egg quality in late-phase laying hens. The experiment was conducted using a completely randomized design. In total, 576 healthy 51-week-old Beinong No. 2 laying hens were randomly assigned to 4 dietary treatments ( = 12): a basal diet (CON) or the basal diet supplemented with 80, 120, or 160 mg/kg α-Ma. The experiment lasted for 4 weeks, after which production performance, egg quality, serum biochemical and antioxidant parameters, inflammatory markers, and uterine gene expression were evaluated. Dietary supplementation with α-mangostin, particularly at 120 mg/kg, significantly improved feed efficiency ( < 0.05), as evidenced by a reduced feed-to-egg ratio from week 2 onward, without affecting average daily feed intake or egg production rate. After 4 weeks, hens receiving 120 mg/kg α-Ma exhibited significantly greater egg weight and eggshell strength ( < 0.05). Serum and hepatic antioxidant capacities were significantly enhanced, with increased glutathione peroxidase and catalase activities, elevated total antioxidant capacity, and decreased malondialdehyde levels ( < 0.05). Moreover, α-Ma at 120 mg/kg specifically lowered the concentration of the pro-inflammatory cytokine interleukin-1β in both serum and uterine tissue ( < 0.05). At the molecular level, this dosage significantly upregulated uterine genes essential for eggshell formation ( < 0.05), including calcium transporters (, ), the matrix protein gene , and other key genes (, , , and ). In conclusion, dietary supplementation with 120 mg/kg α-Ma effectively enhances feed efficiency, strengthens antioxidant and anti-inflammatory defenses, and upregulates uterine genes involved in biomineralization, thereby improving eggshell quality in aging laying hens. These findings support α-Ma as a promising plant-based feed additive for maintaining productivity and egg quality in antibiotic-free layer production systems. - Source: PubMed
Publication date: 2026/04/05
Huang LuQin RuixinYu QianqianYan QiliQi Desheng