Ask about this productRelated genes to: PCGF4 antibody
- Gene:
- BMI1 NIH gene
- Name:
- BMI1 proto-oncogene, polycomb ring finger
- Previous symbol:
- PCGF4
- Synonyms:
- RNF51
- Chromosome:
- 10p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-01-05
- Date modifiied:
- 2016-10-05
Related products to: PCGF4 antibody
Related articles to: PCGF4 antibody
- This study evaluated the effects of replacing dietary glucose with fructose on intestinal development in weaned pigs and assessed epithelial growth using a small intestinal organoid model. A total of 26 weaned pigs ([Yorkshire × Landrace] × Duroc, 21 days old) were randomly assigned to three groups: a control group (10 pigs, 3% glucose), a low-fructose (LF) group (8 pigs, 1.5% glucose + 1.5% fructose), and a high-fructose (HF) group (8 pigs, 3% fructose), with one pig per pen. The experimental period lasted 28 days, including a dietary transition on day 15. Results showed that dietary fructose did not affect growth performance (P > 0.10). Fecal scores were not significantly different among treatments (0.05 < P < 0.1), although numerically lower values were observed in the LF group. The HF group had a greater relative length of the large intestine than the LF group (P < 0.05), whereas the LF group showed reduced kidney weight (P < 0.001). Regarding intestinal morphology, dietary fructose tended to reduce duodenal crypt depth and ileal villus height (0.05 < P < 0.1). Ileal malondialdehyde (MDA) levels were affected by dietary treatment (P < 0.05), whereas digestive enzyme activities were not altered (P > 0.10). At the molecular level, fructose significantly downregulated genes involved in carbohydrate metabolism (FBP1, FBP2, LDHA, PKM) and glucose transport (GLUT2) (P < 0.05). Stem cell-associated genes (LGR5 and BMI1) and tight junction-related genes (OCLN and CLDN1) were significantly downregulated (P < 0.05), whereas Ki67 expression was not significantly affected (P > 0.10). In organoid cultures, fructose concentrations did not affect budding efficiency (P > 0.10), but significantly affected the number of buds per organoid (P < 0.05), with higher values observed at 1 mM and 5 mM. Overall, replacing dietary glucose with fructose did not impair growth performance, but altered oxidative status, epithelial-related gene expression, and intestinal epithelial responses in weaned pigs. These findings indicate that intestinal responses are sensitive to dietary monosaccharide composition under practical feeding conditions. - Source: PubMed
Publication date: 2026/05/07
Wang MinWang XinZeng YutongGuo MingmingWang ZhaobinYin LanmeiWang QiyeLi JianzhongYang Huansheng - The high incidence and recurrence of hepatoma necessitate better prognostic tools. Given the established cytotoxic role of CD4+ T cells, this study aimed to identify CD4+ T cell-related genes (TRGs) and their mechanisms in hepatoma. - Source: PubMed
Publication date: 2026/04/27
Zhang ZheweiGuo LiwenLuo JunZheng JiapingZeng Hui - Radiation-induced intestinal injury is a widely used model for studying mechanisms regulating tissue injury and regeneration. Traditionally, Cesium ( Cs) radiation has been used in research applications, but over the past decade, X-ray irradiation has become increasingly favored due to its improved safety and non-radioactive profile. Since each type of radiation has distinct physical characteristics that drive its performance, we sought to systematically compare the effects of the X-ray and Cs irradiators on intestinal epithelial injury and regeneration. Using established models, including colorectal cancer cell lines such as HCT116, RKO, and DLD-1, and mouse intestinal organoids, alongside model, ; , we evaluated differences in transcriptional, protein, and histopathological responses to irradiation. Our results demonstrate that X-ray produced intestinal injury and regenerative responses comparable to those induced by Cs, supporting its reliability as an alternative modality for studying intestinal radiation. - Source: PubMed
Publication date: 2026/04/21
Lakha RabinaOrzechowska-Licari Emilia JKesavan SahaanaWu Zhi JRotoli MatthewGiarrizzo MichaelYang Vincent WBialkowska Agnieszka B - Osteoarthritis (OA) is the most prevalent degenerative joint disorder worldwide, characterized by impaired anabolic activity and excessive catabolic responses in chondrocytes. However, the precise mechanisms governing chondrocyte homeostasis during OA progression remain unclear. - Source: PubMed
Publication date: 2026/05/01
Zhang Xiao-FeiZhang Bo-WenWu FanWang Zi-XuanPan Wen-MingCao Chu-YiLv Xin-YuRen Tian-XingXu Wei-HuaWang HuiZhang Jin-Xiang - Endometrial receptivity lacks robust biomarkers. Given its role in stabilizing the progesterone receptor, the epigenetic regulator BMI1 is a key candidate, yet its clinical potential is undefined. This study aimed to characterize BMI1's expression and functional role in receptivity and evaluate its utility as a biomarker for predicting reproductive outcomes. - Source: PubMed
Publication date: 2026/04/08
Liu MeiliMao JianaYao YanyanTu LiliZhang Kemei