Ask about this productRelated genes to: HSPBAP1 antibody
- Gene:
- HSPBAP1 NIH gene
- Name:
- HSPB1 associated protein 1
- Previous symbol:
- -
- Synonyms:
- FLJ22623, PASS1
- Chromosome:
- 3q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-28
- Date modifiied:
- 2016-01-26
Related products to: HSPBAP1 antibody
Related articles to: HSPBAP1 antibody
- Feeding behavior is a fundamental biological process closely linked to development, growth, metabolism, and immune regulation in animals. In livestock production, it serves as both an indicator of health status and a selection criterion for breeding programs aimed at improving feed efficiency and adaptive behavior. However, the genetic basis and regulatory mechanisms governing these traits remain poorly understood. In this study, we investigated the genomic architecture of feeding behavior in 205 slow-growing yellow broilers using whole-genome sequencing and high-resolution behavioral phenotyping recorded by automated feeders. Six feeding behavior traits - average daily feed intake, number of daily visits, daily feeding duration, feeding duration per visit, feed intake per visit, and feeding rate - along with 17 production traits in 205 slow-growing yellow broilers were analyzed. SNP-based heritability estimates ranged from 0.30 to 0.69, indicating moderate to high genetic control. Phenotypic and genetic correlations showed significant positive correlations with residual feed intake, suggesting their potential as breeding indicators of feed efficiency. Genome-wide association studies (GWAS) identified seven single nucleotide polymorphisms (SNPs) and three structural variants (SVs) significantly associated with time-related and intake-related feeding traits. Functional annotation and regulatory element prediction highlighted candidate genes, including SMARCC1, SLC15A2, SEMA5B, LRIG1, ARHGAP39, HSPBAP1, and MAPK15, which, based on public databases, were expressed across multiple tissues but showed relatively higher levels in neuro-related tissues, with the retina emerging as a common site of high expression. These genes are involved in chromatin remodeling, neuropeptide transport, retinal development, and stress response, supporting a potential regulatory role of the brain-retina axis in feeding behavior. Together, our findings identify candidate genomic loci and biological pathways associated with feeding behavior, providing new insights into the neural regulation of appetite and valuable molecular targets for genetic improvement of feed efficiency and animal welfare in poultry breeding. - Source: PubMed
Publication date: 2026/01/12
Wang PingZhai ShuangshuangZhao YangDai YuchiLi ChengxuanZheng YingyingMa ChunmeiYang NingYan Wei - Reproductive traits of cattle, especially the Nelore breed, have notable importance in the global economy and are recognized throughout the beef cattle production system. Therefore, we aimed to identify regulatory networks of transcription factors (TFs) and the most promising candidate genes for scrotal circumference (SC), testicular hypoplasia (HT), and sexual precocity (SP) that were previously identified in GWAS analysis. We identified 444 genes from a peer-reviewed systematic review related to male reproductive traits. Biological processes were then identified using DAVID 6.8, and a regulatory network of TFs was constructed. Enriched biological processes and seven candidate genes (BICC1, CDH1, FOXG1, GHR, OR52E4, SLC17A7, and ITGA2) were identified, which were associated with some biological processes linked to reproduction. Furthermore, gene-TF networks were obtained from TFs (GABPA, HNF1A, HNF4A, PAX2, and TFAP2A) associated with bovine reproduction, and the 22 most promising candidate genes (CDKN2C, CLPTM1L, GCSAM, GPR12, GTF3A, HSPBAP1, IL32, ILDR1, LOC100141258, LOC100336282, LOC107131530, LOC112449111, LOC618541, LOC781785, MIX23, MTIF3, PARP9, PCED1B, RNASE2, SLC39A2, SPA17 and TMEM253) were found to be specifically linked to sexual precocity. The identified candidate genes and transcription factors have significant potential to influence the evaluated traits in Nelore bulls. Future research and applications of these genetic factors may improve the breeding and enhancement of Nelore cattle. - Source: PubMed
Publication date: 2025/07/25
Silva Evandro NevesDos Santos Thaís Cristina FerreiraVerardo Lucas LimaMagalhães Ana Fabrícia BragaDos Santos Silva Danielly Beraldo - To investigate the mechanisms through which ferrous ion (Fe) addition improves the utilization of a cottonseed meal (CSM) diet, two experimental diets with equal nitrogen and energy content (low-cottonseed meal (LCM) and high-cottonseed meal (HCM) diets, respectively) containing 16.31% and 38.46% CSM were prepared. Additionally, the HCM diet was supplemented with graded levels of FeSO·7HO to establish two different Fe supplementation groups (HCM + 0.2%Fe and HCM + 0.4%Fe). Juvenile (grass carps) (5.0 ± 0.5 g) were fed one of these four diets (HCM, LCM, HCM + 0.2%Fe and HCM + 0.4%Fe diets) for eight weeks. Our findings revealed that the HCM diet significantly increased lipid peroxide (LPO) concentration and the expression of lipogenic genes, e.g., sterol regulatory element binding transcription factor 1 () and stearoyl-CoA desaturase (), leading to excessive lipid droplet deposition in the liver ( < 0.05). However, these effects were significantly reduced in the HCM + 0.2%Fe and HCM + 0.4%Fe groups ( < 0.05). Plasma high-density lipoprotein (HDL) concentration was also significantly lower in the HCM and HCM + 0.2%Fe groups compared to the LCM group ( < 0.05), whereas low-density lipoprotein (LDL) concentration was significantly higher in the HCM + 0.2%Fe and HCM + 0.4%Fe groups than in the LCM group ( < 0.05). Furthermore, the plasma levels of liver functional indices, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and glucose (GLU), were significantly lower in the HCM + 0.4%Fe group ( < 0.05). Regarding the expression of genes related to iron transport regulation, transferrin 2 () expression in the HCM group and Fe supplementation groups were significantly suppressed compared to the LCM group ( < 0.05). The addition of 0.4% Fe in the HCM diet activated expression and suppressed ferroportin-1 () expression ( < 0.05). Compared to the LCM group, the expression of genes associated with ferroptosis and inflammation, including acyl-CoA synthetase long-chain family member 4b (), lysophosphatidylcholine acyltransferase 3 (), cyclooxygenase (), interleukin 1β (), and nuclear factor kappa b (), were significantly increased in the HCM group ( < 0.05), whereas Fe supplementation in the HCM diet significantly inhibited their expression ( < 0.05) and significantly suppressed lipoxygenase () expression ( < 0.05). Compared with the HCM group without Fe supplementation, Fe supplementation in the HCM diet significantly upregulated the expression of genes associated with ferroptosis, such as heat shock protein beta-associated protein1 (), glutamate cysteine ligase (), and glutathione peroxidase 4a () ( < 0.05), and significantly decreased the expression of the inflammation-related genes interleukin 15/10 (/) ( < 0.05). In conclusion, FeSO·7HO supplementation in the HCM diet maintained iron transport and homeostasis in the liver of juvenile grass carps, thus reducing the occurrence of ferroptosis and alleviating hepatic lipid deposition and inflammatory responses caused by high dietary CSM contents. - Source: PubMed
Publication date: 2023/11/06
Liu HengchenChen ShiyouLin YanJiang WenqiangZhao YongfengLu SiyueMiao LinghongGe Xianping - To identify a diagnostic blood transcriptomic signature that distinguishes multisystem inflammatory syndrome in children (MIS-C) from Kawasaki disease (KD), bacterial infections, and viral infections. - Source: PubMed
Jackson Heather RMiglietta LucaHabgood-Coote DominicD'Souza GiselleShah PriyenNichols SamuelVito OrtensiaPowell OliverDavidson Maisey SalinaShimizu ChisatoAgyeman Philipp K ABeudeker Coco RBrengel-Pesce KarenCarrol Enitan DCarter Michael JDe TishamEleftheriou IriniEmonts MariekeEpalza CristinaGeorgiou PantelisDe Groot RonaldFidler KatyFink Colinvan Keulen DaniëlleKuijpers TacoMoll HenriettePapatheodorou IrenePaulus StephanePokorn MarkoPollard Andrew JRivero-Calle IreneRojo PabloSecka FatouSchlapbach Luregn JTremoulet Adriana HTsolia MariaUsuf EffuaVan Der Flier MichielVon Both UlrichVermont ClementienYeung ShunmayZavadska DaceZenz WernerCoin Lachlan J MCunnington AubreyBurns Jane CWright VictoriaMartinon-Torres FedericoHerberg Jethro ARodriguez-Manzano JesusKaforou MyrsiniLevin Michael - Chronic fatigue is common in patients with psoriasis, and heat-shock proteins (HSPs) have been suggested to influence fatigue. - Source: PubMed
Publication date: 2022/03/07
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