Ask about this productRelated genes to: CCND1 antibody
- Gene:
- CCND1 NIH gene
- Name:
- cyclin D1
- Previous symbol:
- BCL1, D11S287E, PRAD1
- Synonyms:
- U21B31
- Chromosome:
- 11q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-06
- Date modifiied:
- 2019-04-23
Related products to: CCND1 antibody
Related articles to: CCND1 antibody
- Dopaminylation, the covalent attachment of dopamine to the side chain of glutamine in proteins, represents a newly characterized class of posttranslational modifications. Because of the limited identification of substrates, the functions and molecular mechanisms associated with dopaminylation remain largely uncharacterized. Using an alkyne-functionalized dopamine probe, we developed a method for selectively enriching dopaminylated proteins in whole-cell systems. This approach provided a comprehensive resource of 4,133 dopamine-enriched protein candidates and peptide-level analysis with acid-cleavable tags identified 1,181 putative dopaminylated proteins, including histone H4 dopaminylation at Q27 (H4Q27dop), which we further validated. Functionally, H4Q27dop acts as a transcriptional repressor in a neuroblastoma model, where it blocks CEBPD binding at the CCND1 promoter, leading to transcriptional downregulation of CCND1 and subsequent suppression of cell proliferation. Our findings provide both a valuable resource of dopaminylated substrate proteins and a distinct mechanistic insight into how dopamine regulates neuroblastoma cell growth. - Source: PubMed
Publication date: 2026/05/08
Zhang YinfengYang YaqiWu WenyanZhang MinRao JiananSong WentingPan YiShen NanLi LinxueMin TaishanLi KaiZhang XiaoqingQiu Xin-YueZhang Shu-YuYang WenjunZang JianyeLiu YuMo Xi - - Source: PubMed
Ji Y PZhang J HZhou YWang Y FWang S YLin LWang JZhai C W - - Source: PubMed
Wu R NWu X KLiu XYi H M - - Source: PubMed
Ahmed Ahmed ATadros Saber - Early recurrence after curative resection remains a major challenge in hepatocellular carcinoma (HCC), particularly in hepatitis B virus (HBV)-related cases. Liquid biopsy using circulating microRNAs (miRNAs) offers a non-invasive approach to identify molecular markers predictive of recurrence. - Source: PubMed
Publication date: 2026/05/06
Kim Sang-HoonLee RyunjinTak EunyoungKim Ki-Hun